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Mechanical behavior of bioactive glass/polyvinyl alcohol hybrid foams for bone tissue engineering

Bioactive glass/ polymer hybrids are materials of high interest for biomedicals applications because their assets, they combine the bioactivity of ceramics, with the flexibility of the polymers. In bone regenerations, mechanicals properties of the scaffold are criticisms and they must be similar to the bone properties. In previous works, hybrid foams with 80% bioactive glass and 20% polyvinyl alcohol (PVA) were prepared by sol-gel process to application as scaffold for bone tissue engineering. In this work, the PVA fraction of the hybrids was increase for to improve their mechanicals properties. The hybrids were prepared with composition inorganic of 70%SiO2-30%CaO and PVA fractions of 20 to 60% by sol-gel method. The drying of the foams was a criticism stage, occurring ample contraction from the gel. The samples were drying for two routes: (1) pre-drying at 40ºC for 7 days and drying at vacuum for 48 hours; (2) pre-drying with air circulation at 40ºC for 7 days and drying at high vacuum for 48 hours. The drying route 2 had the most lost of water and the least contraction of samples. Five specimens of hybrids samples with dimensions 10x10x10mm were compressed at 0,5mm/min-1. The increase of PVA fraction in the hybrids improves their mechanicals properties.

Hybrids; bioactive glass; polymer; scaffolds; drying; compression


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