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Histological analysis of PLLA/PCL as a meniscal prothesis

The numerous scientific papers applying bioreabsorbable polymers as biomaterial, since 1966, shows the growing interest of researchers in various parts of the world due to its wide range of applications in medicine, such as guided tissue regeneration, controlled release of drugs, support for cells culture, orthopaedic implants, among others. In order to analyze the histologically PLLA / PCL poly (lactic-acid / poly ( caprolactone) blends composition 70/30 with 3% of plasticizer for application as a meniscal prothesis, a study was performed in vivo in rabbits, which were subjected to total removal of the medial meniscus of the knee, and in one of the knees was implanted in the prosthesis and blend another without implant, served as control. after 8, 16 and 24 weeks, were collected them, along with a prosthesis the tissue around it, the femoral condyle of the prosthesis and the femoral condyle control. The materials were subjected to histological analysis by optical microscopy. The results showed that after 24 weeks, there was the formation of a tissue-type fibrocartilage, indicating that the blend studied presents great potential to be used for application in question, since the material promotes the tissue formation o very similar to the meniscus.

PLLA; PCL meniscus; prothesis


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