Assessment of levels of otoacoustic emission response in neonates with perinatal asphyxia

Ribeiro, Georgea Espindola; Silva, Daniela Polo Camargo da; Montovani, Jair Cortez

doi:10.1590/0103-0582201432307

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Revista Paulista de Pediatria

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ORIGINAL ARTICLES • Rev. paul. pediatr. 32 (3) • Sept 2014 • https://doi.org/10.1590/0103-0582201432307 copy

Assessment of levels of otoacoustic emission response in neonates with perinatal asphyxia^☆ ☆ Study conducted at: Departament of Oftalmology, Otorrinolaringology and Head and Neck Surgery, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

To evaluate the effects of perinatal asphyxia on the level of the response to transient otoacoustic emissions in infants.

Methods:

Otoacoustic emissions in 154 neonates were performed: 54 infants who suffered asphyxia at birth, measured by Apgar score and medical diagnosis, and 100 infants without risk were compared. Scores less than 4 in the first minute and/or less than 6 in the fifth minute were considered as "low Apgar". Statistical analysis of the data was performed using the Kruskal, Wilcoxon, and Mann-Whitney nonparametric tests.

Results:

Lower levels of response were observed in transient otoacoustic emission in the group that suffered perinatal asphyxia, with significant values for the frequencies 2,000, 3,000, and 4,000 Hz in the right ear, and 2,000 and 4,000 Hz in the left ear.

Conclusions:

The analysis of the intrinsic characteristics of the otoacoustic emissions evidenced low performance of outer hair cells in neonates who had perinatal asphyxia, which may affect the development of listening skills in this population.

Asphyxia neonatorum; Apgar score; Neonatal screening

Variable	n (%)
Female	93 (60.4%)
Male	61 (39.8%)
GA (weeks)^a a Summary in median, minimum, and maximum; GA, gestational age; BW, birth weight	39 (37-41)
BW (grams)^a a Summary in median, minimum, and maximum; GA, gestational age; BW, birth weight	3.281 (2.170-4.610)

	37 weeks			38 weeks				39 weeks				40 weeks				41 weeks
	med	min	max	med	min	max	med	min	max	med	min	max	med	min	max
AMP_2,000Hz_RE	13	6	28	12	5	24	11	6	29	14	6	29	11	6	24	0.764
AMP_3,000Hz_RE	15	6	23	15	6	26	15	6	30	16	6	29	17	6	21	0.933
AMP_4,000Hz_RE	14	6	26	14	7	26	15	6	27	15	6	29	14	6	27	0.986
AMP_2,000Hz_LE	11	6	28	10	6	24	15	6	28	14	6	28	11.5	6	29	0.337
AMP_3,000Hz_LE	16	7	20	14	6	27	15	6	26	12	6	35	13.5	6	30	0.847
AMP_4,000Hz_LE	13	6	29	13	7	26	17	6	31	15	6	27	14	7	30	0.289

		AMP 2,000Hz-RE	AMP 3,000Hz-OD	AMP 4,000Hz-OD	AMP 2,000Hz-OE	AMP 3,000Hz-OE	AMP 4,000Hz-OE
BW	r	0.04	0.15	0.05	0.10	0.04	0.02
	p	0.633	0.068	0.557	0.209	0.641	0.810
	n	154	154	154	154	154	154

	Female			Male			p
	Median	Minimum	Maximum	Median	Minimum	Maximum
AMP_2,000Hz_RE	14	6	29	11	5	28	0.012^a a ≤0.05 Mann-Whitney test
AMP_3,000Hz_RE	17	6	30	14	6	26	0.000^a a ≤0.05 Mann-Whitney test
AMP_4,000Hz_RE	17	7	29	14	6	26	0.000^a a ≤0.05 Mann-Whitney test
AMP_2,000Hz_LE	14	6	29	11	6	25	0.054
AMP_3,000Hz_LE	15	6	30	12	6	35	0.041^a a ≤0.05 Mann-Whitney test
AMP_4,000Hz_LE	15	6	30	14	6	31	0.167

	Without perinatal asphyxia (100)			With perinatal asphyxia (54)			p
	median	minimum	maximum	median	minimum	maximum
AMP_2,000Hz_RE	14	5	29	11	6	24	0.007^a a ≤0.05 Mann-Whitney test
AMP_3,000Hz_RE	16	6	30	14	6	26	0.009^a a ≤0.05 Mann-Whitney test
AMP_4,000Hz_RE	15	6	29	12	6	27	0.010^a a ≤0.05 Mann-Whitney test
AMP_2,000Hz_LE	14	6	29	10.5	6	25	0.017^a a ≤0.05 Mann-Whitney test
AMP_3,000Hz_LE	14	6	35	11.5	6	27	0.087
AMP_4,000Hz_LE	15.5	6	31	13	6	30	0.039^a a ≤0.05 Mann-Whitney test

Sociedade de Pediatria de São Paulo R. Maria Figueiredo, 595 - 10o andar, 04002-003 São Paulo - SP - Brasil, Tel./Fax: (11 55) 3284-0308; 3289-9809; 3284-0051 - São Paulo - SP - Brazil
E-mail: rpp@spsp.org.br

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[1] *Corresponding author. E-mail: georgea_espindola@hotmail.com (G.E. Ribeiro).

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Assessment of levels of otoacoustic emission response in neonates with perinatal asphyxia☆ ☆ Study conducted at: Departament of Oftalmology, Otorrinolaringology and Head and Neck Surgery, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Objective:

Methods:

Results:

Conclusions:

Assessment of levels of otoacoustic emission response in neonates with perinatal asphyxia^☆ ☆ Study conducted at: Departament of Oftalmology, Otorrinolaringology and Head and Neck Surgery, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.