| MF1 Serum creatinine duplication |
| MF2 Use of nephrotoxin (e.g., aminoglycosides, cyclosporine, tacrolimus, and vancomycin) and increasing creatinine (Cr) |
| MF3 Hepatotoxic medicinal products and elevated liver enzymes |
| MF4 Hypoglycemia (<2 mmol/L egg 40 mg/dL) |
| MF5 Constipation related to opiates with intermittent laxative |
| MF6 Administration of naloxone (Narcan) |
| MF7 Warfarin triggers: RNI >6 |
| MF7 High drug levels (antiepileptics): phenytoin (>30 μg/mL) |
| MF8 High drug levels (antiepileptics): oxcarbazepine (>45 μg/mL) |
| MF9 Bilirubin >25 mg/dL (<28 days of age) |
| MF10 Administration of flumazenil |
| MF11 Abrupt discontinuation of medication |
| Care environment module – AC |
| AC1 Infiltrations: infiltration/extravasation or phlebitis documentation |
| AC2 Pressure injury record (≥stage 2) |
| AC3 Embolus/thrombosis record |
| AC4 Infiltrations: administration of hyaluronidase |
| AC5 Health-associated infections: positive Clostridioides difficile test |
| AC6 Patient fall |
| Iras module – MI |
| MI1 Health-associated infections: positive blood culture (only after 48 h after admission) |
| MI2 Health-associated infections: positive urine culture (only after 48 h after admission) |
| MI3 Health-related infections: positive respiratory or gastrointestinal (GI) viral infection (only after 48 h after admission) |
| MI4 Oral vancomycin |
| MI5 Surgical site inf ection |
| Transfers and outcomes module – TD |
| TD1 Unplanned hospital readmission within 30 days |
| TD2 Cardiorespiratory arrest or rapid response team activation |
| TD3 All deaths of hospitalized patients |
| Surgical module – MC |
| MC1 Hemoglobin (Hgb) or hematocrit (Hct) drop of >25% in <24 h |
| MC2 Mechanical ventilation for a period of >48 h postoperatively |
| MC3 Return to the operating room |
| MC4 Operative time >6 h (noncardiac patients) |
| MC5 Intraoperative epinephrine, norepinephrine, or phenylephrine (noncardiac patients) |
| MC6 Change in procedure |
| Intensive care module – IT |
| TI1 Endotracheal extubation failure (reintubation within 24 h of planned extubation) |
| TI2 Use of racemic adrenaline (mechanically ventilated patients in the last 24 h) |
| TI3 ICU readmission within 24 h after discharge/transfer |
| TI4 Unplanned endotracheal extubation |
| TI5 Transfer to a higher level of care |