| Guardamagna et al(7), 2011, Italy |
Cross-sectional |
To investigate, in children and adolescents with familial dyslipidemia,
the association between Lp (a) and family history for CVD, and whether this
association is independentof the altered lipid profile |
231 children and adolescents(2-18 years) |
Family history for CVD, anthropometric measurements (weight and height),
BMI calculation; lipid profile measurements (TC, HDL-c, LDL-c and TG) and
Lp(a) |
% of patients with elevated Lp(a) levels was higher in those with family
history for CVD. No significant correlation was found between Lp(a), age,
BMI and lipid profile. |
| Sáez de Lafuente et al(8), 2006, Spain |
Cross-sectional |
To determinethe Lp(a) distribution in children and its relationship with
anthropometric variables, lipid and thrombogenic factors |
98 healthy children (6-7 years) |
Anthropometric measurements (weight and height), BMI calculation;Family
history for CVD, lipid profile measurements(TC, HDL-c, LDL-c and TG), Lp(a),
fibrinogen, D-dimer and PAI-1 |
+ correlation between Lp(a) and LDL-c; high Lp(a) levels in children with
family history for CVD. Lp(a) without correlation with thrombogenic
factors; |
| Meabe et al(3), 2006, Spain |
Cross-sectional |
To evaluate the Lp(a) distribution in children and assess its association
withlipid profile and anthropometric variables |
98 healthy children (6-7 years) |
Anthropometric measurements (weight and height), BMI calculation;Family
history for CVD, lipid profile measurements(TC, HDL-c, LDL-c and TG), Lp(a),
Apo A1 and Apo B |
High Lp(a) levels associated with LDL-c and Apo B |
| Wang et al(9), 2005, United States |
Cross-sectional |
To assess the effects of age and sex in the Lp (a) distribution and its
relationship to other risk factors for CVD and diabetes among patients
participating in the Study of Diabetes in Cherokee |
2,182 participants(5-40 years) |
Calculation of BMI, waist-hip ratio, body fat percentage, SBP measurement,
lipid profile measurements(TC, HDL-c, LDL-c and TG), glucose, insulin, OGTT,
Lp(a), Apo and Apo B |
In girls 5 to 19 years old, Lp(a) levels were associated with TC, LDL-c
and Apo. |
| Obisesan et al
(10), 2004, United States |
Cross-sectional |
To determine the correlation of Lp (a) in children andadolescents in the
United States |
3,585 children and adolescents (4-19 years) |
Calculation of BMI, weight, height and WC, family history for CVD,
birthweight, lipid profile measurements(TC, HDL-c, LDL-c and TG) |
Ethnicity is associated with Lp(a) (higher in blacks). TC and family
history associated with elevated Lp(a) levels. |
| Glowinska et al(11), 2003, Poland |
Cross-sectional |
To assess levels of novel risk factors for atherosclerosis in children and
adolescents with obesity, hypertension and diabetes |
285 children and adolescents(6-20 years)5 groups: Control; Obese; Obese
& hypertensive; Hypertensive; Diabetic |
Anthropometric measurements (weight and height), BMI calculation, SBP
measurement, lipid profile measurement (TC, HDL-c, LDL-c and TG), Lp(a), Apo
A1, Apo B, homocysteine, fibrinogen, t-PA, PAI-1 |
Obese, hypertensive and diabetic patients had significant changes in lipid
metabolism, especially in TC, LDL-c, TG, Lp(a), Apo A1 and Apo B
levels. |
| Gillum(12), 2001, United States |
Cross-sectional |
To examine the association between body fat distribution and
apolipoproteins, Lp (a) and TG in a representative sample of black, white
and Hispanic children in the United States |
5,056 children(4-11 years) |
Anthropometric measures (WC, HC, WHR, WTR, subscapular and triceps
skinfolds), calculation of BMI, TG, Lp(a), Apo A1, Apo B |
Lp(a) was not associated with body fat distribution, regardless of age and
BMI. |
