Multivesicular hydatid cyst of the kidney

A 62-year-old female patient was referred to the hospital with fever, acute urinary retention, and hydatiduria associated with a 5-month left flank pain. Hematological data showed slight leukocytosis (12,700 mm³) and moderate eosinophilia (9%). Serological tests were positive for antibodies against Echinococcus granulosus. Computed tomography (CT) of the abdomen revealed multiple hydatid forms ranging from 0.5 to 2.0 cm in diameter, involving all renal segments (Figure 1). The patient had end-stage chronic renal failure and underwent radical nephrectomy. Hydatidosis of the kidney was massive with numerous large and small cysts, which was suggestive of multivesicular renal hydatid infection (Figure 2a and b).

FIGURE 1:
Computed tomography showing multivesicular involvement in the left kidney.

FIGURE 2:
Posterior view of the resected left kidney (a) and multivesicular echinococcosis (arrows) in the cortex and medulla of the kidney (b).

A polymerase chain reaction (PCR) was performed using hydatid fluid. The specific primers MS1 and MS2 were used to amplify the mitochondrial NADH subunit I (nad1) gene¹. For amplification of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene, JB3 and JB4.5 primers were used². The pathological and molecular findings confirmed E. granulosus and G1 genotype (Figure 3a and b).

FIGURE 3:
Cystic mass with protoscoleces (hematoxylin and eosin, ×400) (a), analysis of PCR products; Lane M: molecular weight marker, lane 1: positive control (420 bp), lane 2: negative control, lane 3: E. granulosus isolated from the patient (420 bp) (b).

The patient was treated with albendazole 10 mg/kg/day in two divided doses for 3 weeks in order to ensure protective protoscolicidal doses during the surgical procedure³. Cystic hydatid disease is extremely rare, and the incidence of renal involvement is about 2% in all hydatidosis cases. In endemic areas, physicians must have good knowledge about the disease and must be aware of its clinical presentation and complications. Molecular methods such as PCR of hydatid fluid may be necessary for the differential species diagnosis.

Acknowledgment

We acknowledge the patient who provided us complete information about his condition.

REFERENCES

• ¹
  Sharbatkhori M, Mirhendi H, Jex AR, Pangasa A, Campbell BE, Kia EB, et al. Genetic categorization of Echinococcus granulosus from humans and herbivorous hosts in Iran using an integrated mutation scanning-phylogenetic approach. Electrophoresis. 2009;30(15):2648-55.
• ²
  Bowles J, Blair D, McManus DP. Genetic variants within the genus Echinococcus identified by mitochondrial DNA sequencing. Mol Biochem Parasitol. 1992;54(2):165-73.
• ³
  Baradan Bagheri A, Zibaei M, Tayebi Arasteh M. Cystic echinococcosis: a rare case of brain localization. Iran J Parasitol 2017;12(1):152-5.

Publication Dates

• Publication in this collection
  11 Apr 2019
• Date of issue
  2019

History

• Received
  08 Sept 2018
• Accepted
  20 Dec 2018