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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0427-2017   copy

HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.

METHODS:

PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.

RESULTS:

There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.

CONCLUSIONS:

The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.

Keywords:
Hepatitis C virus; Human platelets antigens; Hepatocellular carcinoma

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