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Short Communications • Rev. Soc. Bras. Med. Trop. 48 (4) • Jul-Aug 2015 • https://doi.org/10.1590/0037-8682-0041-2015   copy

Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

Authorship SCIMAGO INSTITUTIONS RANKINGS

INTRODUCTION:

Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.

METHODS:

We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.

RESULTS:

Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.

CONCLUSIONS:

Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.

Klebsiella pneumonia; KPC; Polymyxin B; Colistin

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