Factors associated with a diagnosis of major depression among
HIV-infected elderly patients

Carmo Filho, Aureo do; Fakoury, Max Kopti; Eyer-Silva, Walter de Araujo; Neves-Motta, Rogério; Kalil, Rosangela Souza; Ferry, Fernando Raphael de Almeida

doi:10.1590/0037-8682-1228-2013

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Revista da Sociedade Brasileira de Medicina Tropical

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Sumário

Short Communications • Rev. Soc. Bras. Med. Trop. 46 (3) • May-Jun 2013 • https://doi.org/10.1590/0037-8682-1228-2013 copy

Factors associated with a diagnosis of major depression among HIV-infected elderly patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

Introduction

Acquired immunodeficiency syndrome (AIDS) is being increasingly reported among the elderly and major depression (MD) may be associated with suboptimal adherence to treatment.

Methods

Cross-sectional study on factors associated with MD among 72 HIV-infected elderly individuals.

Results

Twenty (27.7%) patients were found to have MD. The female gender (odds ratio [OR] = 10.65; p = 0.00586), a low CD4 count during the study (OR = 1.005247; p = 0.01539), and current smoking status (OR = 12.89; p = 0.01693) were independently associated with MD.

Conclusions

Our data underscore the need to attentively search and treat MD among HIV-infected elderly patients.

Aging; Elderly; HIV infection; Major depression

	Patients with a diagnosis of depression (n = 20)	Patients without a diagnosis of major depression (n = 52)	P value
Female sex: n (%)	15 (75.0)	22 (42.3)	0.01779
Age at diagnosis (years): mean ± SD	59.8 ± 8.9	59.7 ± 6.1	0.995
Age as of the study (years): mean ± SD	68 ± 6.9	67.3 ± 5.1	0.9849
CD4 count/mm³3. Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry 2001; 158:725-730. at baseline: mean ± SD	257 ± 188	223 ± 195	0.3996
Current CD4 count/mm³3. Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry 2001; 158:725-730.: mean ± SD	344 ± 146	557 ± 340	0.002603
Viral load below detection limits: n (%)	13 (65.0)	37 (71.1)	0.7758
Level of education (years): mean ± SD	5.5 ± 4.2	6.9 ± 4.7	0.3466
Length of antiretroviral therapy (years): mean ± SD	8.2 ± 5.9	7.5 ± 3.6	0.9649
Antiretroviral regimen included efavirenz: n (%)	5 (25.0)	12 (23.0)	1
Body mass index (kg/m²2. Blanco JR, Caro AM, Pérez-Cachafeiro S, Gutiérrez F, Iribarren JA, González-García J, et al. HIV infection and aging. AIDS Rev 2010; 12:218-230.): mean ± SD	22.6 ± 3.9	24.8 ± 6.0	0.3131
Arterial hypertension: n (%)	11 (55.0)	25 (48.0)	0.793
Dyslipidemia: n (%)	8 (40.0)	18 (34.6)	0.7855
Diabetes mellitus: n (%)	4 (20.0)	9 (17.3)	0.7457
Sedentary lifestyle: n (%)	20 (100.0)	44 (84.6)	0.09614
Current cigarette smoker: n (%)	6 (30.0)	4 (7.7)	0.02309

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[1] Address to: Prof. Fernando Raphael de Almeida Ferry. Hospital Universitário Gaffrée e Guinl/UNIRIO. Rua Mariz e Barros 775/10ª Enfermaria, 20270-004 Rio de Janeiro, RJ, Brasil. Phone: 55 21 2264-4035. e-mail: ferry@unirio.br