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Communications • Rev. Soc. Bras. Med. Trop. 39 (4) • Aug 2006 • https://doi.org/10.1590/S0037-86822006000400014   copy

Assessment of chemiluminescence and PCR effectiveness in relation to conventional serological tests for the diagnosis of Chagas' disease

Avaliação da eficiência da quimiluminescência e PCR em relação aos testes sorológicos convencionais para o diagnóstico da doença de Chagas

Authorship SCIMAGO INSTITUTIONS RANKINGS

While testing 414 sera for the diagnosis of Chagas' disease, the conventional reactions of indirect hemagglutination, indirect immunofluorescence and the immunosorbent assay showed a sensitivity of 95.7%, 100% and 98.2% and a specificity of 98%, 98% and 96.4%, respectively, and an excellent association using Fisher's exact test. Chemiluminescence presented 100% sensitivity and 89.6% specificity, while PCR showed 100% specificity and 1.2% sensitivity. It is believed that the three conventional serological reactions are still adequate for diagnosing Chagas' disease.

Chagas' disease; Diagnosis; Serology; Chemiluminescence; PCR

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