Two cases of muco-cutaneous histoplasmosis in brothers are presented. The first case under specific treatment improved, quickly but had recidive with lecions in the nervous system, three years afterwards, leading to death. In the second cave, the diagnosis was performed earlier and under specific treatment clinical cure ocurred. The pacient is still under clinical control. In both cases, the clinical aspects of muco-cutaneous ristoplasmosis were similar to those of South American blastomycosis (paracoccidicdcmycosis). The firts diagnosis was post-mortem and the second one was by fungus isolation, in culture, and the presence of the Histoplasma capsulatum in the histological sections.