Negative serology of <i>Fasciola hepatica</i> infection in patients with liver cancer in Peru: a preliminary report

Machicado, Claudia; Bertani, Stéphane; Herrera-Velit, Patricia; Espinoza, Jose; Ruiz, Eloy; Marcos, Luis

doi:10.1590/0037-8682-0180-2017

Short Communication • Rev. Soc. Bras. Med. Trop. 51 (02) • Mar-Apr 2018 • https://doi.org/10.1590/0037-8682-0180-2017 linkcopy

Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report

Authorship SCIMAGO INSTITUTIONS RANKINGS

INTRODUCTION: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients.

METHODS In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA.

RESULTS Fas2-ELISA demonstrated negative results in all HCC patients included in this study.

CONCLUSIONS The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.

Keywords:
Cholangiocarcinoma; Fasciolosis; Fibrosis; Hepatocellular carcinoma; Liver fluke

Patient number	Age	Sex	Tumor type	Living place	Birth place	OD value*	Fas2-ELISA
						(Fas2-ELISA)	result
1	24	M	HCC	Lambayeque	Lambayeque	0.047	Negative
2	41	M	HCC	Lima	Lima	0.152	Negative
3	37	F	HCC	Lima	Lima	0.064	Negative
4	18	M	HCC	Lima	Junín	0.066	Negative
5	33	M	HCC	Lima	Lima	0.021	Negative
6	30	M	HCC	Huancavelica	Huancavelica	0.019	Negative
7	27	M	HCC	Junín	Junín	0.055	Negative
8	61	M	HCC	Cusco	Cusco	0.052	Negative
9	22	F	HCC	Ayacucho	Ayacucho	0.098	Negative
10	58	M	HCC	Junín	Junín	0.09	Negative
11	81	M	HCC	Lima	Huánuco	0.045	Negative
12	84	F	CCA with liver metastases	Lima	Lima	0.023	Negative
13	23	M	HCC	Huánuco	Huánuco	0.04	Negative

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Sociedade Brasileira de Medicina Tropical - SBMT Sociedade Brasileira de Medicina Tropical - SBMT, Núcleo de Medicina Tropical UnB, Sala 43C 70904-970, E-mails: rsbmt@sbmt.org.br | artes.rsbmt@gmail.com , WhatsApp: SBMT (61) 9.9192-6496, WhatsApp: RSBMT (34) 3317-5855 - Brasília - DF - Brazil
E-mail: rsbmt@sbmt.org.br

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[TFN2] OD: optical density; Fas2-ELISA: enzyme-linked immunosorbent assay; M: male; F: female; HCC: hepatocellular carcinoma; CCA: cholangiocarcinoma. *OD measured at 450nm.