Disseminated cryptococcosis manifested as a single tumor in an immunocompetent patient, similar to the cutaneous primary forms

Cryptococcosis is a fungal infection caused by Cryptococcus neoformans that tends to affect immunocompromised individuals. The fungi are mostly acquired by inhalation, which leads to an initial pulmonary infection. Later, other organs - such as the central nervous system and the skin - can be affected by hematogenous spread. In addition, cutaneous contamination can occur by primary inoculation after injuries (primary cutaneous cryptococcosis), whose diagnosis is defined based on the absence of systemic involvement. The clinical presentation of cutaneous forms typically vary according to the infection mode. We report an unusual case of disseminated cryptococcosis in an immunocompetent patient with cutaneous lesions similar to those caused by primary inoculation. This clinical picture leads us to question the definition of primary cutaneous cryptococcosis established in the literature.


INTRODUCTION
Cryptococcosis is a fungal infection caused by two varieties of Cryptococcus neoformans, which are divided into five serotypes: serotypes A, D, and AD (C. neoformans var. neoformans) and serotypes B and C (C. neoformans var. gatti). 1 Serotype A has a worldwide distribution and is found in most of Brazil; serotype D is found mainly in the Europe; and C.
neoformans var. gattii is limited to tropical and subtropical areas. 2 This fungus has a wide environmental distribution and is found in tree branches, bird feces, soil, fruit, and vegetables. 3 Low global frequency of cryptococcosis indicates that the host immune response is sufficient to prevent demonstrations in most immunocompetent patients. However, the disease has been increasingly found in immunocompromised patients, especially HIV-infected individuals. 1,2 The disease is spread mostly through inhalation of fungi, which usually cause asymptomatic pulmonary infection. However, the disease can spread through the blood, affecting preferably the  prognostic significance (high titers can be predictors of disseminated disease) and serves for therapeutic monitoring. 6 If infection is present in one area, without CNS involvement or immunosuppression, the treatment is conducted with oral fluconazole, 400 mg/daily for 6-12 months. For cryptococcal meningitis, recommended treatment consists of a two-week induction therapy with intravenous amphotericin B, 0.7-1 mg/kg/day, followed by a consolidation phase with oral fluconazole 800mg/day for eight weeks. Thereafter, maintenance therapy with fluconazole 400 mg/ day is suggested for 6-12 months, or until immune restoration. 7 We report an unusual case of DC in an immunocompetent patient with skin lesions similar to those caused by primary cutane-

CASE REPORT
We report a 68-year-old white male patient born and raised in Tupi (SP), rural worker, who complained about a 30-day asymptomatic lesion on his right forearm, with progressive growth and subsequent ulceration. He reported that he had handled a mortar bag two days before the lesion occurred.
The patient presented with poorly defined erythematous plaque (about 25cm in size) on the right forearm, displaying multiple nodules on the surface, some with fluctuation and discharging gelatinous secretion after puncture, and some ulcerated areas covered by crusts (Figures 1-3).
He also reported holocranial tension headache, of low intensity, three days before, associated with nausea and asthenia. He   Our patient was treated with intravenous liposomal amphotericin B, 5mg/kg/day for two weeks, followed by fluconazole, with a 12-month treatment. Response to treatment was favorable showing an almost complete remission of cutaneous lesions in six months. The patient is being followed up.

Skin involvement in DC patients occurs in approximately
10% of cases, which may be the primary manifestation of the disease and an early sign of dissemination. 2,4,8 However, PCC is rare and still controversial.
PCC occurs in a population with different personal features (age, gender), immune status, geographic locations compared to DC, suggesting that the diseases are clinically distinct entities.
PCC has a predilection for immunocompetent or immunocompromised elderly male patients residents of rural areas. 9 Cellulitis and ulceration in a limited and exposed cutaneous area, especially on the upper limbs, are the most common manifestations. Gelatinous exudation is common. Most cases present a local trauma history and exposure to bird feces. 3 DC cutaneous lesions usually spread affecting unexposed and exposed areas. Lesions can appear in any type: umbilicated (mimicking molluscum contagiosum), acneiform, nodular, herpetiform, and cellulitis-like lesions. 4,9 However, lesions mimicking PCC, as reported in our case, are an exceptional feature.
Systemic cryptococcal infection in immunocompetent patients, as in our case, is rare. Some cases of opportunistic infections have been reported in chronic users of high doses of inhaled corticosteroids, particularly pulmonary aspergillosis, but no DC report was found in the literature. 10 Despite the prolonged use of inhaled corticosteroids by our patient, we observed no immunosuppression in the immunologic research.
Based on our report, we question, therefore, the validity of the current concept of PCC and DC as different entities. Our patient lived in the rural area, was apparently immunocompetent, and presented with a lesion on an exposed area, features suggestive of