Discharge guidance and telephone follow-up in the therapeutic adherence of heart failure: randomized clinical trial

Objective to evaluate the effectiveness of the behavioral intervention of discharge guidance and telephone follow-up in the therapeutic adherence, re-hospitalization and mortality of patients with heart failure. Method randomized clinical trial without blinding, including 201 patients diagnosed with heart failure admitted to the emergency room, who were randomized in Control Group and Intervention Group. Intervention was carried out with specific discharge guidance in the Intervention Group, who were contacted for solving doubts via phone calls after 7 and 30 days, and the adherence to treatment was evaluated after 90 days with the Morisky test, the Brief Medical Questionnaire and the non-drug adherence test in both groups. The Generalized Estimating Equations Model was used (p<0.05%). Results One-hundred and one patients were randomly sorted in the Control Group and in the Intervention Group, their average age being 62.6±15.2. The Intervention Group had higher drug and non-drug therapeutic adherence compared to the Control Group (p<0.001) and there were lower re-hospitalization and death rates in the Intervention Group after 90 days. Conclusion discharge guidance with telephone follow-up was effective and resulted in greater therapeutic adherence, as well as in decrease of re-hospitalization and death rates in patients with heart failure. Clinical Trial Registration (REBEC): RBR- 37n859


Introduction
Heart Failure (HF) represents a problem with great magnitude, as it is the second most common cause of death due to cardiovascular diseases in Brazil. The demand for emergency services on the part of this population is frequent, and the rates of hospitalization due to clinical complications are high, this having been a recurring public health problem for almost 20 years (1)(2)(3) .
The high number of hospital admissions due to HF, nearly one million annual hospitalizations, is commonly associated with decompensation of the disease, which can be triggered by cardiovascular factors, like ischemia and arrhythmias, and non-cardiovascular factors, like various types of infection. Another important factor in the clinical decompensation of these patients is the non-adherence to the treatment recommended for the disease (4)(5) .
It is estimated that 50% of patients with chronic diseases do not adhere to treatment, due to voluntary of involuntary factors such as not knowing the medications, not understanding the medical prescription, lack of belief in the treatment and the patients' psychosocial conditions (6) .
Discharge guidance is an important factor in the improvement of the patient's understanding of the disease and of adherence to treatment. For an effective discharge guidance, it is important that it is conducted individually and according to the patients' understanding of their disease (7)(8) .
Studies reinforce the association of education in health with the improvement of the patients' knowledge about HF, and the nurse plays an important role in the patient's education and adherence to treatment (9)(10) .
The literature demonstrates that telephone follow-up has been efficient, because patients who received calls after discharge that were intended to solve doubts, control signs and symptoms and guide treatment, adhered more to the therapy proposed, and there was decrease of the demand for care in the emergency units, as well as of the re-hospitalization and death rates (11)(12) .
The high rate of re-hospitalization due to decompensation of HF leads to large expenses for the health system, in addition to increasing these patients' morbidity and mortality (3) . In this context, the use of strategies that can substantially increase these individuals' adherence to treatment should be considered by the inter-professional health team.
Individualized hospital discharge guidance and telephone follow-up appear as strategies in health that can be performed by the nurse to optimize self-care (11)(12) , improving the therapeutic adherence of patients with HF and decreasing the demand for hospital care.
Given the above, the purpose of this study was to verify whether a behavioral strategy consisting of telephone follow-up and individualized guidance given by the nurse contributes to increasing the drug adherence of patients with HF in a scenario where national research addressing this subject is still scarce. In this context, this study aimed to evaluate the effectiveness of the behavioral intervention of discharge guidance and telephone follow-up in the therapeutic adherence, re-hospitalization and mortality rates of patients with heart failure.

Method
This was a randomized clinical trial, with 201 participants, drawn electronically and without blinding. exercises, importance of drug adherence and return to the emergency service in case of worsening of the signs and symptoms. Three months after hospital discharge, the CG was contacted via telephone by the researcher, who evaluated their adherence to and the barriers to non-adherence to pharmacological measures, their adherence to non-pharmacological measures, as well as the occurrence of re-hospitalization and death in the period. The call was, on average, 15 minutes long.
The IG was given discharge guidance by the researcher, on the bed of the hospitalized patients and in the presence of whoever was accompanying them at that moment. As a first step, the researcher evaluated the patient's previous knowledge regarding the disease and treatment, with a structured questionnaire based on the literature (1,8,13) . Thirty days after hospital discharge, the IG patients were contacted via telephone by the researcher to clarify doubts and to identify difficulties regarding treatment.
In addition, it was identified if there had been cases of re-hospitalization or death during this period. The calls were, on average, 10 minutes long.
The evaluation of the effectiveness of the intervention in the IG was performed 90 days after hospital discharge, by telephone.
Therapeutic adherence based on drug and nondrug adherence and on the barriers for non-adherence were considered as primary outcomes, and the secondary outcomes included the occurrence of rehospitalization and death seven, 30 and 90 days after hospital discharge.
With the aim of characterizing the study's patients, an instrument with sociodemographic and clinical variables was devised, including: age, sex, education, length of hospitalization, marital status, occupation, weight, height, waist circumference, past occurrences and personal habits, and physical activity.
Physical activity was classified as follows: physically active individuals were considered to be those who practiced aerobic physical activities such as walking, running, cycling, dancing or swimming, three to five times a week for 30 to 60 minutes (13) .
The Morisky Green Test (MGT) was used to assess the patient's adherence to the drug treatment, and consists of four questions: 1) Do you sometimes have trouble remembering to take your medication? 2) Do you sometimes neglect taking your medication?
3) When you are feeling better, do you sometimes stop taking your medication? 4) Sometimes, if you feel worse while taking the medication, do you stop taking it? The patient was classified as having "high adherence" when the answers to the four questions were negative; when one or two answers were positive, the patient was classified as having "moderate adherence", and with three or four positive answers, he/she was classified as having "low adherence" (14) .
To identify the barriers to adherence to treatment, from the patient's perspective, the Brief Medication  (14) .
To evaluate adherence to non-drug treatment, a questionnaire was devised including three your salt intake as instructed by the health care professional? 3) Do you control your water intake as instructed by the health care professional? The patient was classified as having "high adherence" when the answers to the three questions were positive; when one or two answers were positive, the patient was classified as having "moderate adherence", and with three negative answers, he/she was classified as having "low adherence" (1) .
Data collection was divided into four phases: 1)

Results
The average age of the patients (n=201) was 62.6±15.2 years old, and the intervention and control groups were homogeneous with regard to the socio-demographic and clinical variables (p > 0.05), as noted in Table 1.
Adherence and the barriers to drug and non-drug adherence are presented in Table 2.  In relation to drug adherence, there was statistically significant difference between the CG and the IG 90 days after hospital discharge. IG patients showed higher drug adherence, being 3.8 more likely to adhere when compared to patients of the CG in the same period.
As for the barriers to adherence in both CG and IG, the regimen barrier was the most prevalent, with statistically significant difference between the CG and the IG in relation to the presence of belief, regimen and memory barriers, which were more present in the CG, the IG being 1.89 times more likely to have negative barriers when compared to the CG.
With regard to non-drug adherence, there is a significant difference between the groups in relation to Adherence and Likely Adherence. The IG has a higher percentage of Adherence compared to the CG, being 1.2 times more likely of being Adherent than the CG after the intervention.
Regarding re-hospitalization, there was statistically significant difference (p<0.0001) between the two groups 90 days after the intervention. The IG has a lower re-hospitalization rate when compared to the CG.
As for mortality, the IG has a lower death rate when compared to the CG, as noted in Table 3.

Discussion
The results of this study showed that there is statistically significant difference with regard to drug and non-drug adherence between patients undergoing specific discharge guidance and telephone follow-up to treatment, self-monitoring of decompensation signs and symptoms, and self-care in relation to HF (15) .
The main purpose of nursing education for HF patients is that they understand the importance of adherence to treatment and the signs and symptoms of decompensation. Education in health, promoted by different strategies, can positively impact the treatment of HF; both telephone follow-up and domiciliary visits have been proven as effective to increase the adherence and self-care of this population (16) .
With respect to barriers to drug adherence, this study showed that the main one was the regimen barrier, suggesting the patients' difficulty in understanding the guidelines on the prescription of medicines, which is worsened by polypharmacy (6) .
In relation to the belief barrier, which evaluates to what extent the patient believes the treatment may improve or control the disease, it was evidenced that the CG had a higher belief barrier percentage in relation to the IG. It can be inferred that after the intervention, the patients had better knowledge of the disease and of the importance of treatment, contributing to their belief in its effectiveness, which can improve their self-management of the disease and increase their adherence to the proposed therapy (7) . As for the presence of the memory barrier, a higher percentage was observed in the CG, which suggests that, after undergoing an educational intervention on the importance of treatment, individuals are less likely to forget about the medications and how to use them.
In this study, 16.6% of the total patients had high non-drug adherence, with difference between the groups: 7.6% of the CG and 25.3% of the IG. Non-drug adherence consists in suitable water restriction when indicated, restriction of salt intake and daily control of weight, and can be referenced as the target that is most difficult to be achieved in the treatment of HF, as it is related to changes of behavior and life habits (17) . A systematic review that examined 17 studies on self-care and chronic diseases, including HF, corroborates the idea that the patient's self-care in relation to the disease is directly related with the decrease in mortality and rehospitalization rates, needing thus to be addressed in education in health (18) .
The adherence to treatment of chronic patients has been shown to be a critical issue in the field of health (19) , as low adherence is directly related to re-hospitalization due to HF. The interventions carried out in this study contributed to lower re-hospitalization rates 90 days after the patients had been discharged, as 38.6% of the patients in the CG and 26% of those in the IG were hospitalized during this period (p=0.0310).
In relation to mortality, in this study, 7% of the total patients died, 8.9% in the CG and 5% in the IG, 90 days after discharge. A study assessing the impact of telephone follow-up on patients with HF also showed reduction in the mortality rate of these individuals (19) . Education in health, when carried out appropriately, can directly and significantly influence the mortality of patients with HF by improving these patients' understanding of the disease, its treatment and, consequently, their adherence to therapy, with increased survival rates and improvements in their quality of life (19)(20) .
This study had as limitation the patients' follow-up

Conclusion
This research concluded that the dual educational intervention, with guidance at the moment of and telephone follow-up after discharge of patients with HF in an emergency service is effective, and resulted in greater therapeutic adherence and reduction of barriers to it, in addition to decreasing re-hospitalization and mortality rates, as proposed.