Archives of Endocrinology and Metabolism (AE&M) is the official journal of the Brazilian Society of Endocrinology and Metabolism (SBEM), affiliated with the Brazilian Medical Association. Published since 1951, AE&M focuses on publishing scientific articles across the basic, translational, and clinical areas of Endocrinology and Metabolism. The journal is available exclusively online and offers full open access.

Formerly known as Arquivos Brasileiros de Endocrinologia e Metabologia (ABE&M), AE&M is the official scientific journal of SBEM. It serves as a forum for the following medical organizations and associations of interest in the areas of Endocrinology and Metabolism: Brazilian Diabetes Society (SBD) and the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO). The journal is published regularly, with six issues per year, and is made available online on the AE&M homepage and SciELO.

To expedite the dissemination of research results, AE&M has adopted a rolling publishing model. This approach allows the rapid availability of articles soon after final acceptance, ensuring that scientific findings can be accessed more promptly by researchers, clinicians, and the general public.

AE&M follows the Gold Open Access model.

The Open Science movement advocates for collaborative, transparent, and public scientific practices.

Archives of Endocrinology and Metabolism (AE&M) adheres to the Gold Open Access model. This model promotes guidelines for a collaborative, shared, and public scientific practice, which are reflected in our editorial policies aimed at ensuring full transparency and free access to knowledge.

Peer Review Process: AE&M follows a rigorous peer review process with continuous flow, upholding its adherence to open science principles.

Publication of Preprints and Open Access: AE&M supports the publication of preprints and provides open access to all articles, ensuring that discoveries and innovations in endocrinology and metabolism are freely accessible to researchers, clinicians, and the general public.

Code of Good Practice: AE&M promotes a code of good research practice for authors, reviewers, and editors, encouraging the sharing of additional datasets and materials in open institutional repositories.

Transparency in Authorship: To reinforce transparency and academic responsibility, AE&M requires precise identification of each author's role in multi-authored articles.

Open Science Compliance Form: During manuscript submission, authors are required to complete the Open Science Compliance Form, where authors share manuscript information with the journal and how it aligns with Open Science communication practices.

AE&M supports the ethical standards recommended by the Committee on Publication Ethics (COPE), the Council of Science Editors (CSE) , and the World Association of Medical Editors (WAME) regarding ethical standards of publication. AE&M is dedicated to maintaining integrity and ethics in scientific publishing and adopts strict measures to prevent scientific misconduct.

Among the forms of misconduct, plagiarism, data fabrication, falsification, redundant or duplicate publication, violation of federal, state, or institutional rules, and honorary authorship stand out. AE&M does not tolerate any form of scientific misconduct and takes immediate action to address suspected cases.

The Editorial Board of AE&M utilizes Similarity Check software to detect similarities in submitted materials and prevent cases of plagiarism and duplication. If misconduct is identified, the Editorial Board will discuss the matter and take appropriate decisions, which may include suspending publication in the journal for a specified period. The authors involved will be immediately informed at each stage of the process.

AE&M emphasizes that authors bear full responsibility for the content of their articles, including concepts, ideas or opinions expressed, as well as the origin and accuracy of the citations. The journal will not hesitate to publish errata, corrections, retractions, and apologies when necessary to correct inaccurate or misleading information.

AE&M is committed to integrity and ethics in scientific publication and continues to improve its processes and policies to ensure the quality and credibility of published articles.

To ensure the integrity and reliability of results and conclusions in scientific manuscripts using chatbots, and to maintain public confidence in the findings presented, AE&M supports WAME recommendations (https://wame.org/page3.php?id=106) regarding the ethical considerations related to the use of these technologies in scientific manuscripts, namely:

• Transparency: Authors must be transparent about the use of chatbots in the manuscript writing process. This includes providing detailed information about the technology used (name, version, model, and source) and specifying the role of chatbots played in text development.
• Accountability: Authors are responsible for the work performed by chatbots on their manuscripts, including ensuring the accuracy of the content and the absence of plagiarism. Human authors must also be able to assert that there their articles, including text produced by chatbots, are free from plagiarism.
• Attribution: Authors must ensure proper attribution of all sources, including material produced by chatbots. Authors should also seek out and cite sources that support statements made by chatbots.
• Limitations: Authors should discuss the limitations and potential biases of using chatbots in the production of scientific texts, such as their inability to understand nuances or ambiguities in language.

AE&M requests authors to disclose the use of generative artificial intelligence (AI) and AI-assisted technologies in the writing process by adding a statement at the end of the manuscript in the main text file, before the list of references. This statement should be placed in a new section titled “Statement of Use of Generative AI and AI-Assisted Technologies in the Writing Process”.

The statement must contain the following information: “During the process of preparation of this article, the author(s) used [TOOL/SERVICE NAME] for [PURPOSE]. After using this tool/service, the author(s) reviewed and edited the content as necessary and assume full responsibility for the content of the publication".

It is important to note that this statement is not required for the use of basic text revision tools, such as spelling and grammar checkers, or for managing bibliographic references. If generative AI or AI-assisted technologies were not used in the writing process, adding the statement is unnecessary.

The Archives of Endocrinology and Metabolism – AE&M – is an open access, peer-reviewed journal dedicated to publishing and disseminating original research in endocrinology, diabetes, and metabolism. The journal's mission is to promote the advancement of knowledge in these fields and contribute to the development of new therapies and clinical approaches.

The journal is an official publication of the Brazilian Society of Endocrinology and Metabology (SBEM) and is indexed in several national and international databases, enhancing the visibility and accessibility of published articles. AE&M serves as an important source of information and updates for researchers, health professionals, and students interested in endocrinology, diabetes, and metabolism.

This journal adheres to the standards defined in the SciELO Program Digital Preservation Policy.

• Chemical Abstracts
• DOAJ
• EBESCO
• Excerpta Medica
• Google Scholar
• LILACS
• OpenAlex
• PubMed®/MEDLINE®
• SCOPUS
• SUDOC
• Web of Science
• ZDB

• Journal title: Archives of Endocrinology and Metabolism – AE&M
• Abbreviation: Arch Endocrinol Metab
• Published by: Brazilian Society of Endocrinology and Metabolism – SBEM
• Frequency: Annual
• Publication mode: rolling publishing
• Year established: 1951

• LinkedIn: https://www.linkedin.com/company/archendometab/
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The Archives of Endocrinology and Metabolism (AE&M) encourages open access and information sharing to generate knowledge among researchers who need it to support their work. AE&M accepts manuscripts that have been self-archived in preprint repositories such as arXiv, MedRxiv, PeerJ, and Research Square, among others, provided the repository does not restrict copyright and author reuse rights. Authors who have deposited their manuscripts on a preprint server must ensure that the license required by the platform is compatible with AE&M's copyright policy and vice-versa.

A preprint is a complete version of a scientific work that has not yet undergone peer-review. Preprints operate independently of the journal, and their publication does not affect the peer review process. Preprints can be posted at any time during the peer review process. AE&M endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) and only accepts preprints that have the following features:

• Clear identification that the manuscript deposited on the preprint server has not yet been peer-reviewed;
• Indication of the funding sources on the deposited manuscript;
• The preprint server allows to submit a revised version of a manuscript at any time (prior to acceptance).

AE&M requires authors to complete the Open Science Compliance Form and submit it as a SUPPLEMENTARY FILE along with the manuscript. This form will be accessible to reviewers. AE&M encourages editors to include any comments or opinions regarding the manuscript in Additional Information (Form), so that these can be taken into consideration when providing feedback to the authors.

If the manuscript is accepted by AE&M, authors must update the preprint article to include the following information: “This is an original manuscript of an article published by Archives of Endocrinology and Metabolism on [publication date], available at: [URL and DOI]”.

AE&M does not accept articles deposited on preprint servers available for the digital press, such as Academia.edu or ResearchGate, or those released outside the scientific community before or during the submission and review process at AE&M. AE&M advises authors and institutions to avoid seeking publicity and press coverage at the preprint stage, as conclusions may change after peer-review. Premature release may inaccurately reflect the results. AE&M recommends that authors and institutions only issue press releases for articles posted as preprints after they have been published.

AE&M does not accept preprints of the following article categories: narrative reviews, case reports, editorial/opinion/commentary articles, correspondence related to articles published in other journals, or articles that do not include new research and laboratory protocols.

AE&M requests that any preprints be listed in the ACKNOWLEDGMENTS section and that the full citation be included in the reference list.

The peer review process is a critical component of the article publishing process and helps ensure the quality and credibility of the published work.

AE&M adopts a single-anonymized review system for approved manuscripts, in which the reviewers know the names and affiliations of the authors, but the reports sent to the authors are anonymous. Based on their evaluations, reviewers can recommend the manuscript be accepted, rejected, or revised in terms of form and content. Reviewers’ opinions are considered by the Associated Editors and the Editor-in-Chief, who then issue a final feedback report to authors. Rebuttals after the final decision of the Editorial Board are not accepted.

Reviewers are experts in the field of the manuscript and are selected based on their expertise and experience. They assess the scientific quality, originality, and relevance of the submitted work, as well as the clarity of writing and compliance with publication standards.

For manuscripts submitted as preprints, the peer review process maintains the same level of scientific rigor. However, preprints may be made publicly available prior to the completion of the peer review process. During the review, reviewers have access to the preprints to evaluate the scientific quality and originality of the work, and authors can receive preliminary feedback to improve their manuscripts. This practice allows the scientific community to access research findings earlier, promoting transparency and collaboration.

Transparency and Options Policy in Peer Review:

To enhance trust and recognition in the editorial process, AE&M implements a Transparency and Options Policy in Peer Review:

Disclosure of Editors and Reviewers: AE&M is committed to publishing the names of the associate editors and reviewers who participated in the manuscript evaluation in the final article. This initiative aims to ensure transparency and provide credit to the professionals involved in upholding the journal's quality standards.

Transparency Options in the Review Process: AE&M provides authors and reviewers with several options to increase transparency, subject to mutual agreement between the parties:

• Publication of Reviewer Comments: The comments provided by reviewers on approved articles may be published alongside the article, with the option for reviewers to disclose their identities.
• Mutual Disclosure of Identities: During the review process, authors and reviewers may choose to disclose their identities, if all parties agree.

These policies are designed to promote greater transparency in the peer review process, fostering trust in the published research and ensuring proper recognition for the contributions of all involved.

AE&M is committed to the Transparency and Openness Promotion (TOP) guidelines to promote the openness, transparency, and reproducibility of research published by SciELO journals. These guidelines aim to improve the quality and transparency of published research by emphasizing the importance of clarity in the evidence supporting the studies' conclusions.

To align with these principles, AE&M requests that all datasets associated with submitted manuscripts be accompanied by the Open Science Compliance Form. This form must be completed in detail by the authors, highlighting how the research adheres to Open Science standards, and submitted as a Supplementary File with the manuscript.

Furthermore, AE&M recognizes the numerous benefits of archiving research data and expects that all data underlying the published results be deposited in a public repository. The chosen repository should ensure data preservation (see the registry of research data repositories at re3data.org) and facilitate making the data findable, accessible, interoperable, and reusable, according to the FAIR Data Principles (Findable, Accessible, Interoperable, and Reusable).

All accepted manuscripts must include the Open Science Compliance Form as a data availability statement. This form allows authors to indicate whether all data, software codes, and other materials underlying the manuscript text are already available, will be available at the time of publication, or cannot be made available due to legal or ethical reasons. Authors should specify if:

The contents underlying the manuscript text are included within the manuscript, are already available, or will be made available at the time of the article's publication. This should include the titles and respective URLs, access numbers, or DOIs of the files.

If the data cannot be made publicly available, authors must provide a suitable justification in the form. They may also opt to make the data available upon request by reviewers during the evaluation process or to other researchers after publication, provided this condition is justified in the manuscript.

AE&M emphasizes that data sharing in accordance with the FAIR principles allows access to shared data under certain restrictions (such as to protect confidential or proprietary information) but encourages sharing data as openly as possible (while being as restrictive as necessary).

To facilitate the reproducibility and dissemination of data, AE&M encourages the deposit and sharing of research data that support the publication of the article. Authors are encouraged to select a data repository that issues a persistent identifier, preferably a DOI – Digital Object Identifier, and has a robust preservation plan to ensure the perpetuity of the data.

Before choosing a repository, authors should consult their institution to identify the most relevant options for their research. Tools such as FAIRsharing and re3data.org can help locate suitable repositories. Examples of data repositories include Dryad, Figshare, Harvard Dataverse, Mendeley Data, Open Science Framework, and Zenodo.

To ensure the quality and standardization of published articles, the journal requires a Certificate of Proofreading in Advanced English, issued by one of the following companies: Voxmed (www.voxmed.com.br/voxmed/), AJE (www.aje.com), Atlas Assessoria Linguística (www.atlastraducoes.com.br), or Tikinet (www.tikinet.com.br). This requirement applies to authors whose native language is not English, as well in any cases deemed necessary by the editorial team. It does not apply to invited articles.

Article Proof: The corresponding author will receive a proof of the article in text file format (doc, docx or rtf), including observations and changes made by the technical reading team at Segmento Farma Editores.

Deadline for Review: The review period is 4 days. If any questions remain after this period, the editorial team will reach out to ensure necessary revisions are carried out until the final version of the text is complete.

Exceptions: Authors of guest articles are exempt from publication fees for their articles.

AE&M is committed to upholding the highest ethical standards in scientific publishing as recommended by ICMJE, COPE, CSE, and WAME. The goal is to ensure the integrity of published content and maintain the trust of readers, authors, reviewers, and editors.

Misconduct in Publication: Misconduct is defined as any action that includes plagiarism, data falsification, improprieties of authorship, duplicate publication, among other fraudulent practices.

Erratum and Retraction Process:

• Erratum: Errata are issued to correct significant errors in publications that may affect the interpretation of data or information, thereby ensuring the transparency and accuracy of the scientific record.
• Retractions: Published articles may be portrayed for reasons such as significant findings that compromise the validity of the results, evidence of misconduct, or honest errors that completely alter the interpretation of the findings.
• Procedure: The decision to issue an erratum or retraction will be made by the editor-in-chief, following COPE's recommendations. Communication regarding these actions will be clear, transparent, and accessible to all readers.

AE&M requires that all manuscript authors to declare any potential sources of conflict of interest. This includes any financial or personal interests, relationships, or beliefs—whether personal, religious, or political—that could be perceived as influencing an author's objectivity. Potential sources of conflict of interest include, but are not limited to: patent or stock ownership, membership on a company's board of directors, participation in a company's advisory board or committee, and consulting or receiving speaker's fees from a company. The existence of a conflict of interest does not prevent publication. If the authors have no conflict of interest to declare, it must be clear in the cover letter. It is responsibility of the corresponding author to review this policy with all authors and collectively disclose ALL relevant business relationships and any other pertinent interests at the time of submission.

The Editorial Board of AE&M utilizes Similarity Check software to detect similarities in submitted materials, helping to prevent cases of plagiarism and duplicate publications.

The editorial team of AE&M, as well as the authors publishing in the journal, must always adhere to the Sex and Gender Equity in Research – SAGER guidelines. The SAGER guidelines provide a framework for reporting information on sex and gender in study design, data analysis, and the results and interpretation of findings. Additionally, AE&M is committed to gender equity in the composition of its editorial board.

Use of Inclusive Language

AE&M endorses the use of people-first language. In all publications, the focus should be on the person before the disease, as the following examples: “subject with obesity” instead of “obese subject”, and “subject with diabetes” instead of “diabetic subject”. This principle applies to other conditions as well, such as avoiding terms like “acromegalic”, “osteoporotic”, or “hypertensive”. Check your text before posting to avoid unnecessary resubmission delays.

Please read below for further information:

People-First Language as an important tool to fight stigma
Language has a significant impact on perceptions, behavior, motivation and, consequently, health outcomes. The contribution of the medical and scientific community is essential for the evolution of language towards reducing the stigma associated with diseases or disabilities.

The “People First” movement began in 1974, focusing on people with disabilities, which may have contributed to their increasing integration into the community. People-first language was adopted by the American Psychological Association in 1992, with the aim of decreasing the focus that is placed upon the diagnosis and increasing the focus on the person. Since then, it has been widely adopted by various organizations addressing chronic diseases and disabilities (1). People-first language is now the standard for referring to people with chronic diseases in a respectful manner, without labeling them by their illnesses (2).

In recent years, diabetes societies have also become concerned with language choices. Diabetes Australia was the first to publish a position statement in 2012, calling for a “new language for diabetes” (3), followed by the International Diabetes Federation, which wrote a technical document on language philosophy. In 2017, the American Association of Diabetes Educators (AADE) and the American Diabetes Association (ADA) organized a task force on language in diabetes care and education, issuing a document with recommendations for language related to diabetes that is respectful, including, person-centered, and strengths based on diabetes clinicians, educators, researchers, journal editors and authors, and other professionals who communicate about diabetes (4). Since then, the ADA's annually published Standards of Medical Care in Diabetes document includes a recommendation to “use language that is person-centered (e.g., ‘person with diabetes’ is preferred over ‘diabetic’)” (5).

When it comes to obesity, however, the scientific community is one step behind (2). A simple Google Scholar search reveals approximately 13,500 results for "diabetic people", compared to 295,000 for "people with diabetes". In the case of obesity, the opposite is observed: 73,300 results for "obese people" and 11,200 for "people with obesity". Not surprisingly, obesity is a disease strongly associated with stigma in different scenarios (employment, schools, personal relationships) and it is extremely common in healthcare settings as well (2). In this context, according to several studies, individuals stigmatized due to their weight, or blamed by healthcare professionals tend to gain more weight and have poorer health outcomes (6-8). As such, language matters and the use of people-first language could help to fight stigma, avoiding the characterization of an individual by their disease (2). Considering this, the Obesity Coalition Action has called upon authors and editors of scholarly research, scientific writing, and publications about obesity to use people-first language (9). Several organizations have already signed-on, including The Obesity Society, the World Obesity Federation, and the European Association for the Study of Obesity.

The editorial board of the Archives of Endocrinology and Metabolism, aligned with major journals addressing diabetes and obesity, has decided to require the use of people-first language for manuscript publication. We strongly believe that scientific journals should support people-first language to contribute to help reduce bias and stigma. Hopefully, such a paradigm shift in scientific language will contribute to a positive change in healthcare education and practice.

REFERENCES

1. Crocker AF, Smith SN. Person-first language: are we practicing what we preach? J Multidiscip Healthc. 2019;12:125-9.
2. Kyle TK, Puhl RM. Putting people first in obesity. Obesity (Silver Spring). 2014;22(5):1211.
3. Speight J, Conn J, Dunning T, Skinner TC; Diabetes Australia. Diabetes Australia position statement. A new language for diabetes: improving communications with and about people with diabetes. Diabetes Res Clin Pract. 2012;97(3):425-31.
4. Dickinson JK, Guzman SJ, Maryniuk MD, O’Brian CA, Kadohiro JK, Jackson RA, et al. The Use of Language in Diabetes Care and Education. Diabetes Care. 2017;40(12):1790-9.
5. American Diabetes Association. 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S40-S52.
6. Robinson E, Hunger JM, Daly M. Perceived weight status and risk of weight gain across life in US and UK adults. Int J Obes. 2015;39(12):1721-6.
7. Wu YK, Berry DC. Impact of weight stigma on physiological and psychological health outcomes for overweight and obese adults: A systematic review. J Adv Nurs. 2018;74(5):1030-42.
8. Tomiyama AJ, Carr D, Granberg EM, Major B, Robinson E, Sutin AR, et al. How and why weight stigma drives the obesity “epidemic” and harms health. BMC Med. 2018;16(1):123.
9. People-First Language [Internet]. Obesity Action Coalition. [cited 2021 Mar 14]. Available from: https://www.obesityaction.org/action-through-advocacy/weight-bias/people-first-language/

All research involving human subjects or human tissues must adhere to the principles set out in the Declaration of Helsinki (https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-humans/) and must have approval from a Research Ethics Committee or an equivalent. In all experiments involving human beings, it is mandatory to obtain informed consent from the participants and approval from a research ethics committee. This should be clearly stated in the Methods section of the manuscript.

Study populations – details of age, race, and gender relevant to the study content should be described in detail. Participating individuals should be identified only by numbers or letters, never by initials or names. Photographs of patients' faces should only be included if they are scientifically relevant. Authors must obtain written consent from the patient for the use of such photographs, and such consent must be provided at the time of submission.

In experimental work involving animals, the standards established in the Guide for the Care and Use of Laboratory Animals (https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf) andhttps://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf the Brazilian Guidelines on the Care and Use of Animals for Scientific and Didactic Purposes (DBCA) of the National Council for the Control of Animal Experimentation – CONCEA (http://pages.cnpem.br/ceua/wp-content/uploads/sites/56/2015/06/DBCA.pdf) must be followed.

Submitted manuscripts must include a statement confirming that all described experimentation was performed in compliance with accepted standards of animal care as outlined in the Ethical Guidelines. The number of animals used in each group and experiment should be specified. All research animals must be obtained and used in accordance with federal, state, and local laws, as well as institutional regulations.

Manuscripts are recommended to follow the ARRIVE guidelines (https://www.nc3rs.org.uk/arrive-guidelines), developed as part of an NC3Rs initiative to improve the design, analysis, and reporting of animal investigations – improving published information and minimizing unnecessary studies. Experimental work involving animals must also comply with the PREPARE guidelines (https://norecopa.no/prepare), in addition to the Brazilian Guideline (DBCA), as outlined in CONCEA Normative Resolution No. 55 (https://www.in.gov.br/web/dou/-/resolucao-n-55-de-5-de-outubro-de-2022-434869177).

Authors' Copyright: Authors who publish in AE&M retain the copyright to their works. This means that although the article is published under the aegis of AE&M, the intellectual property of the work remains with the authors.

Licensing under Creative Commons: To facilitate the reuse and distribution of works, articles published in AE&M are licensed under the Creative Commons Attribution (CC-BY) license. This license allows third parties to use and share the published works, provided they give the appropriate credit to the original author and AE&M. This approach promotes the ethical and accessible dissemination of scientific knowledge, allowing works to be widely distributed and reused without restrictions.

Correct Citation of Original Work: In compliance with the CC-BY license, any reuse or distribution of articles published in AE&M must include the correct citation of the original work. This ensures that authors receive due recognition for their work and maintains the academic integrity of the publication process. AE&M's copyright policy reflects our commitment to promoting open science and respecting authors' rights and contributions. By publishing in AE&M, authors gain visibility and recognition for their work, while contributing to the advancement of knowledge in their areas of study.

AE&M adopts a copyright policy that aligns with the recommendations of the SciELO Criteria. This policy is essential for protecting the interests of authors while promoting the open and ethical dissemination of scientific knowledge.

Website Responsibility: The copyright terms applied to the content published in AE&M must be clearly stated and differentiated from the copyright terms applied to the website itself. This ensures transparency and a clear understanding of the rights and responsibilities related to both the journal content and the website.

Author(s) Responsibility: The inclusion of generic, trade, trademark, and similar names in this publication does not imply that these names are exempt from copyright restrictions or other pertinent regulations. It is the responsibility of the author(s) to obtain the necessary authorizations for the reuse of any copyrighted material included in their manuscript.
The opinions expressed by the authors are their sole responsibility.

License Adopted by the Journal
All content and articles published by AE&M, unless otherwise specified, are licensed under the Creative Commons Attribution 4.0 International (CC-BY 4.0) license, available at https://creativecommons.org/licenses/by/4.0/deed.pt. Authors retain the copyright of their works while licensing them under this agreement, which allows reuse and distribution without restriction, provided the original work is properly cited.

Self-Archiving by Authors
&M encourages authors to deposit the final published version of their articles in an open access repository, such as an institutional or thematic repository. Authors may deposit their articles immediately after publication, provided they include a link to the published version on the journal's website and properly attribute AE&M for the original publication, along with the correct citation.

Brazilian Society of Endocrinology and Metabolism (SBEM)

• Cesar Luiz Boguszewski, Universidade Federal do Paraná (UFPR), Curitiba, Paraná/PR, Brazil. E-mail: aem.editorial.office@endocrino.org.br, ORCID: https://orcid.org/0000-0001-7285-7941, Lattes: http://lattes.cnpq.br/0690563993355504.

• Celia Regina Nogueira, Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo/SP, Brazil. ORCID: https://orcid.org/0000-0002-4014-0660,
  Lattes: http://lattes.cnpq.br/7607038776901890
• Cristiane Bauermann Leitão, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul/RS, Brazil.
  ORCID: https://orcid.org/0000-0002-2106-309X, Lattes: http://lattes.cnpq.br/3618928357885535
• Davi Casale Aragon, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP/USP), Department of Childcare and Pediatrics, Ribeirão Preto, São Paulo/SP, Brazil.
  ORCID: https://orcid.org/0000-0003-1019-3654, Lattes: http://lattes.cnpq.br/6000284891261012
• Fernanda Vaisman Balieiro, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil.
  ORCID: https://orcid.org/0000-0002-6835-7108, Lattes: http://lattes.cnpq.br/5299551445667541
• Josivan Gomes de Lima, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte/RN, Brazil. ORCID: https://orcid.org/0000-0002-1627-7018,
  Lattes: http://lattes.cnpq.br/6456654111946909
• Larissa Garcia Gomes, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0002-0902-0142,
  Lattes: http://lattes.cnpq.br/8350816517477321
• Leandro Kasuki, Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro (HUCFF/UFRJ), Researcher at the Neuroendocrinology Research Center, Rio de Janeiro, RJ, Brazil. ORCID: https://orcid.org/0000-0003-1339-3192,
  Lattes: http://lattes.cnpq.br/0753220766107668
• Letícia F. Gontijo Silveira, Faculdade de Medicina da Universidade Federal de Minas Gerais (FMUFMG), Belo Horizonte, Minas Gerais/MG, Brazil.
  ORCID: https://orcid.org/0000-0002-0053-9167, Lattes: http://lattes.cnpq.br/2113495112251803
• Luiz Claudio Gonçalves de Castro, Faculty of Medicine, University of Brasília (UNB), Brasília, Distrito Federal/DF, Brazil. ORCID: https://orcid.org/0000-0002-9166-1837,
  Lattes: http://lattes.cnpq.br/0241374469752455
• Madson Queiroz de Almeida, Universidade de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0002-2957-6148,
  Lattes: http://lattes.cnpq.br/7787515012796496
• Marcelo A. Mori, Department of Biochemistry and Tissue Biology, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo/SP, Brazil.
  ORCID: https://orcid.org/0000-0001-7112-5263, Lattes: http://lattes.cnpq.br/3425809117024031
• Marcio C. Mancini, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0003-1278-0406,
  Lattes: http://lattes.cnpq.br/1983170155276689
• Marcio W Lauria, Department of Clinical Medicine, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais/MG, Brazil. ORCID: https://orcid.org/0000-0001-7558-1231, Lattes: http://lattes.cnpq.br/4877941159473142
• Maria Candida Barisson Villares Fragoso, Department of Clinical Medicine, Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo (HCUSP), São Paulo, SP, Brazil.
  ORCID: https://orcid.org/0000-0001-6150-1915, Lattes: http://lattes.cnpq.br/4149401217886825
• Maria Tereza Nunes, Universidade de São Paulo (USP), Instituto de Ciências Biomédicas, São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0003-3375-4020,
  Lattes: http://lattes.cnpq.br/4808814043079266
• Mario José Abdalla Saad, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (UNICAMP) Department of Clinical Medicine, Campinas, São Paulo/SP, Brazil.
  ORCID: https://orcid.org/0000-0003-4544-6105, Lattes: http://lattes.cnpq.br/7159637189296890
• Marise Lazaretti-Castro, Escola Paulista de Medicina – Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0001-9186-2834,
  Lattes: http://lattes.cnpq.br/8253870907570489
• Melanie Rodacki, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
  ORCID: https://orcid.org/0000-0002-9007-1325, Lattes: http://lattes.cnpq.br/8722548326345579
• Miguel Madeira, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
  ORCID: https://orcid.org/0000-0001-6752-2880, Lattes: http://lattes.cnpq.br/9591859150807201
• Rodrigo de Oliveira Moreira, Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, RJ, Brazil. ORCID: https://orcid.org/0000-0003-1561-2926,
  Lattes: http://lattes.cnpq.br/8313280775887526
• Rosália do Prado Padovani, Faculdade de Ciências Médicas da Santa Casa de São Paulo, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
  ORCID: https://orcid.org/0000-0002-5497-6813, Lattes: http://lattes.cnpq.br/6807863839185730
• Simone van de Sande Lee, Departamento de Clínica Médica, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina/SC, Brazil.
  ORCID:  https://orcid.org/0000-0002-5592-1603, Lattes: http://lattes.cnpq.br/6120212472988778
• Sonir R. Antonini, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRPUSP), São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0003-4778-8803,
  Lattes: http://lattes.cnpq.br/5986826931551383
• Vania dos Santos Nunes-Nogueira, Department of Clinical Medicine, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (FMB/UNESP), Botucatu, São Paulo/SP, Brazil.
  ORCID: https://orcid.org/0000-0001-9316-4167, Lattes: http://lattes.cnpq.br/1220262621923147

AE&M strongly encourages authors to ensure that manuscripts meet the quality standards outlined by the Enhancing the Quality and Transparency of Health Research Network (EQUATOR) guidelines (https://www.equator-network.org/). EQUATOR serves as a directory that provides guidelines aimed at improving the reliability of published health research literature by promoting transparent and accurate reporting.

AE&M publishes articles in several categories, including:

Original Articles: Unpublished works presenting original experimental, translational, or clinical research of scientific relevance and significant impact in Endocrinology and Metabolism. This category also includes systematic reviews with meta-analysis.

Requirements for Systematic Reviews with Meta-Analysis

PRISMA Reporting Guidelines: These guidelines help authors transparently report the rationale for their systematic review, the methods used, and the findings.

PRISMA 2020 Statement: Specifically designed to guide the reporting of systematic reviews assessing the effects of interventions. Access the full guidelines at: http://www.prisma-statement.org/

Protocol Registration:

Registration Requirement: All systematic reviews with meta-analysis must be registered on a protocol registration platform before manuscript submission to ensure transparency and reliability.

Registration Platforms:

PROSPERO UK (https://www.crd.york.ac.uk/prospero/): Recommended as the main registration platform.

Open Science Framework (https://osf.io/): Supports pre-registration of various research projects, including systematic reviews.

Research Registry (https://www.researchregistry.com/): Suitable for registering all types of research studies.

Authors must include the registration number obtained from PROSPERO or other relevant platforms in the manuscript at the time of submission.

Consequences of Non-Inclusion: Failure to provide the registration number may lead to delays in the editorial evaluation process or potential rejection of the article.

The original article must contain a maximum of 3,600 words in the main text, include up to six figures and tables, and have up to 60 references.

– Review Articles: These articles provide an overview and critique of a specific topic and are usually solicited by the Editors. If an author wishes to submit an unsolicited review, they should first contact the Editor-in-Chief with an outline of the proposed review and the authors' CVs. While there is no strict limit on word count or reference numbers, the editorial recommendation is to keep the article under 4,000 words, with a maximum of four figures or tables and 100 references. Both invited and unsolicited reviews undergo peer review.
– Brief Communications: These articles present preliminary results or studies with limited scope, new data on significant controversies, or conceptual advancements. They provide a succinct description of confirmatory or negative results from focused, simple, and objective trials. Brief communications should be succinct, limited to 1,500 words (excluding abstract, references, and table/figure captions), with a maximum of two illustrations (tables, figures, or one of each), and no more than 30 references.
– Position Statements, Guidelines, or Consensus: These documents are prepared by experts to guide clinical practice. Editors may suggest a panel of experts to write such articles, preferably using the GRADE system. Consensus statements or guidelines proposed by professional societies, task forces, and other associations related to Endocrinology and Metabolism may also be published by AE&M. All manuscripts will undergo peer review and must be revised in response to feedback; publication will only occur if they meet the journal's editorial standards. Manuscripts must contain up to 3,600 words in the main text, six figures and tables, and up to 60 references.
– Debates: This contribution should be solicited by the Editors and addresses a controversial topic in either basic or clinical endocrinology. Two or more authors are invited to express their contrasting views and interpretations of the current literature. This type of article has a word limit of 1,500, with one figure or table, and a maximum of 30 references.
– Case Reports: This type of article is accepted only when it presents interesting, unusual, and fully documented and investigated clinical cases or series of cases, which substantially enhance knowledge regarding the etiology, pathogenesis, and/or natural history of the condition described. Case reports should contain up to 2,000 words, include four figures and tables, and have a maximum of 30 references.
– Letters to the Editor: These allow opinions and discussions in response to articles published in AE&M in the previous three editions. Original data related to the published article are encouraged. Letters must contain a maximum of 500 words and include up to five complete references. Figures and tables are not permitted.
– Editorials: These contributions, typically solicited by the Editors, focus on the topics of one or more articles published in the same issue of the journal. Editorials have a word limit of 1,500 and may include no more than 20 references.

All authors must confirm that they have sufficiently contributed to the work to take responsibility for significant portions of the manuscript’s content. Each author must specify their contributions to the work. During the submission process, the corresponding author will ensure the accuracy and integrity of all data presented in the manuscript.

AE&M recommends that authorship be based on the criteria established by the ICMJE. Unrestricted co-authorship is allowed. Authorship credit should be granted only for the following:

1. Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; and
2. Drafting the work or reviewing it critically for important intellectual content; and
3. Final approval of the version to be published; and
4. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

All collaborators who do not meet the authorship criteria must be listed in the Acknowledgments section, along with any financial support from funding agencies.

Manuscripts should be submitted as a Microsoft Word file, formatted on A4 paper (210 × 297 mm) with 2 cm margins on all sides. Use Times New Roman or Arial font, size 12, with 1.5 line spacing.

All submissions must include a cover letter highlighting the manuscript's importance and relevance. This letter should also contain the following information: confirmation of any conflicts of interest; assurance that the manuscript is original and has not been published or is not under consideration elsewhere; the ethics committee approval number (for research involving humans and animals). In the case of research carried out in Brazil, the cover letter must contain the CAAE registration number, generated by Plataforma Brasil.

Manuscripts that do not comply with all submission guidelines will be held until the necessary items are completed.

AE&M employs an anonymous peer review process, requiring authors to remove any identifying information from their manuscripts. To facilitate the submission process, authors are encouraged to prepare their manuscripts in separate files as described below:

The Cover Page should be structured as follows:

The title of the article must be in English, concise, and informative.

A brief title of no more than 40 characters for page headers.

Full names of authors with their respective academic degrees.

Each author's affiliation should include: university, department, city, zip code, country, email, and ORCID iD (all authors must have an ORCID – Open Researcher and Contributor ID: https://orcid.org/ signin).

A corresponding author must be indicated.

Include three to five descriptors in English. Descriptors can be found at the following addresses: https://meshb.nlm.nih.gov/MeSHonDemand or https://meshb-prev.nlm.nih.gov/search.

Manuscript configuration: The body text must not contain any information regarding the authors' names or affiliations. It should be structured as follows:

Abstract
Main text (article)
Tables, Graphics, Figures, and/or Photographs (must be cited in the main text in numerical order)
Funding
Acknowledgments

Abstract: Original articles, brief communications and case reports must include an abstract of no more than 250 words. The abstract must contain clear and objective information about the study, allowing understanding without reference to the main text. It must be structured into four sections corresponding to the main text headings. All information reported in the abstract must originate from the manuscript, and complete sentences should be used for all sections.

Introduction: The main goal of the introduction is to engage the reader's interest in the article by offering a historical perspective and justifying its objectives.

Materials and Methods: This section must contain comprehensive details on how the study was conducted, enabling other investigators to evaluate and replicate the work. The origin of hormones, unusual chemicals, reagents, and devices must be indicated. For modified methods, only new modifications should be described.

Statistical Analysis: For manuscripts involving complex statistical analysis carried out by a professional statistician, we encourage authors to provide the statistician's contributions by mentioning their name(s) in the Acknowledgments section if they are not listed as co-authors.
Identify the software used for the analysis (name, version, year). Specify the hypothesis tests or regression models and indicate the purpose of each method. For Bayesian analyses, present the model used, explain the choice of prior distributions, specify the algorithm used, and detail how many samples were generated and discarded. Use the full term "p-value" rather than just "p" in hypothesis tests, and report p-values to two decimal places [for example, if the second decimal place is zero (e.g., p-value = 0.0001), report as p-value < 0.01]. Avoid using the term "statistically significant", since the relevance of the result must be clinical or epidemiological; instead, emphasize the clinical or epidemiological relevance of the results, supported by confidence intervals or effect sizes. We encourage authors to use boxplots or other appropriate graphs to describe means and standard deviations, instead of bar charts with vertical lines indicating error or standard deviation.

Results and Discussion: The Results section should briefly present the experimental data, incorporating both text and tables and/or figures. Avoid repeating results presented in the text that are already shown in tables. For more details on preparing tables and figures, see the sections below. The Discussion should focus on interpreting and explaining the results, with concise and objective comments describing its relationship with other research in the area. Avoid repeating data already presented in the Results section. It may include suggestions to explain those data and conclude with a summary of the main findings.

Unit of Measurement: Results should be expressed using the metric system. Temperature should be expressed in Celsius degrees, and time of day should be presented using the 24-hour clock format (e.g., 08:00 h, 15:00 h).

Standard Abbreviations: All abbreviations must be defined immediately after the first appearance in the text.

Molecular Genetic Description: Use standard terminology for polymorphic variants, providing the rs numbers for all reported variants. Assay details, such as PCR primer sequences, must be briefly described along with the rs numbers. The pedigree charts must be drawn up in accordance with the published standard: Bennett RL, French KS, Resta RG, Doyle DL. Standardized human pedigree nomenclature: update and assessment of the recommendations of the National Society of Genetic Counselors. J Genet Couns. 2008 Oct;17(5):424-33. doi: 10.1007/s10897-008-9169-9.

Nomenclatures: For genes, use genetic notation and symbols approved by the HUGO Gene Nomenclature Committee (HGNC) – (http://www.genenames.org/~V).

For mutations, follow the naming guidelines suggested by the Human Genome Variation Society (http://www.hgvs.org/mutnomen/).

Provide and discuss the Hardy-Weinberg equilibrium data of the analyzed polymorphisms in the studied population. The calculation of Hardy-Weinberg equilibrium can help in discovering genotyping errors and their impact on analytical methods.

Provide the original frequencies of genotypes, alleles, and haplotypes.

Whenever possible, use the generic name of drugs. When a trade name is used, it must begin with a capital letter.

Use acronyms sparingly and fully explain them upon their first mention.

Funding: All sources of research support (if any), including project numbers and responsible institutions, must be declared. The role of funding agencies in the design of the study, data collection, analysis and interpretation, and manuscript writing should be stated in Acknowledgments.

Acknowledgments: All participants who have made substantial contributions to the manuscript (e.g., data collection, analysis, writing, or editing assistance) but do not meet the authorship criteria should be named with their specific contributions in Acknowledgments in the manuscript. The conflict of interest statement must also be included in this section. If the authors have no relevant conflicts of interest to disclose, they must explicitly state this in the Acknowledgments section.

Tables and Figures: Tables and Figures must be numbered according to their order of appearance in the text, contain a title, and be submitted in separate files. Tables must not contain data already mentioned in the text, should be open on the sides, and have a completely white background. Abbreviations used in the tables must be mentioned in alphabetical order in the footer, with their respective full forms. For tables taken from other sources of information or adapted (with proper permission), the credit of the source must be provided at the end of each caption in parentheses. This credit must include a complete bibliographic reference or the copyright information. Likewise, abbreviations used in the figures must be explained in the captions. Only images in JPEG format will be accepted, with minimum resolutions as follows: 1200 dpi for simple black and white graphics, 300 dpi for black and white photographs, and 600 dpi for color photographs. AE&M requests that authors retain the original images, as we may contact you to provide these originals if the submitted images present any printing issues.

Photographs: AE&M prefers to publish photos of unmasked patients. Authors are encouraged to obtain permission from patients or their families before submitting the manuscript for possible image publication. If the manuscript contains identifiable patient images or protected health information, authors must submit documented authorization from the patient, parent, guardian, or legal representative before the material is distributed to AE&M editors, reviewers, and staff. Subjects should be identified using a numerical designation (e.g., Patient 1); initials of names should not be used.

References for printed and electronic documents must adhere to the Vancouver style, as established by the ICMJE. They must be numbered sequentially in parentheses within the text, corresponding to the order of appearance, and listed in the same numerical order on a separate page at the end of the manuscript.

AE&M encourages the use of DOI, as it guarantees a permanent access link to the electronic article. For articles or texts without a DOI published on the internet, include the full URL and the access date. Examples of Vancouver-style citations can be found on the National Library of Medicine (NLM) website at Citing Medicine: https://www.ncbi.nlm.nih.gov/books/NBK7256/.

Example:

Article:
Bein M, Yu OHY, Grandi SM, Frati FYE, Kandil I, Filion KB. Levothyroxine and the risk of adverse pregnancy outcomes in women with subclinical hypothyroidism: a systematic review and meta-analysis. BMC Endocr Disord. 2021;21(1):34. doi: 10.1186/s12902-021-00699-5.

Manuscripts must be submitted and filled online in the ScholarOne system – https://mc04.manuscriptcentral.com/aem-scielo, accompanied by the following items:

• Cover Letter.
• Statement on Research Involving Animals (if applicable).
• The Manuscript.

Each document should be attached separately in the designated field within the system.

To start the submission process, the corresponding author must previously register in the system as an author by creating or associating their ORCID registration at https://orcid.org/signin. All authors are required to have an updated ORCID registration associated with their profile.

When drafting a scientific article, authors must explicitly state the funding sources for their research and publication. It is essential to mention the full names of the organizations that financially supported the study, followed by the respective grant numbers in square brackets, if applicable. For example: "This work was supported by the National Council for Scientific and Technological Development – CNPq [Grant Number/Year]". If the research was conducted without specific funding but as part of the authors' employment, the employer’s name must be included.

Furthermore, all sources of research support, including project numbers and the responsible institution, must be stated in the Funding section. It is crucial to indicate the role of funding agencies in the design of the study, data collection, analysis, interpretation, and manuscript preparation. This practice ensures transparency and integrity of scientific publication.

Sociedade Brasileira de Endocrinologia e Metabologia
Rua Botucatu, 572 - Conjuntos 81/83
Vila Clementino, Zip Code: 04023-062
São Paulo, SP, Brazil
Phones: (+55 11) 5575-0311 / (+55 11) 9 9768-6933
E-mail: aem.editorial.office@endocrino.org.br