ISSN 0074-0276 printed version
ISSN 1678-8060 online version



Scope and policy

The Memórias do Instituto Oswaldo Cruz is a multidisciplinary journal which publishes original research throughout the fields of tropical medicine (including pathology, field epidemiology and clinical studies) medical and veterinary parasitology (including protozoology, helminthology, entomology and malacology), and medical microbiology (virology, bacteriology and mycology). It particularly welcomes basic and applied research in biochemistry, immunology, molecular and cell biology, physiology, pharmacology and genetics related to these fields. Short communications are also considered. Review articles are invited. The journal publishes eight issues constituting one volume per year. Occasionally papers presented at symposia or congresses are published as supplements.

Submitted papers must be written in English. English of low quality is a major cause of delay in publication and we strongly advise authors with English as a foreign language to have their manuscripts checked by someone with English as a first language, preferably a scientist.

Submission of a paper to the Memórias is understood to imply that is has not previously been published (except in an abstract form), and that it is not being considered for publication elsewhere. Responsibility for the accuracy of the material in the manuscript, including bibliographic citations, lies entirely with the authors.

Manuscripts will be peer-reviewed; acceptance will be based on scientific content and presentation of the material.

Submission of manuscripts will only be accepted when submitted electronically using the following link:

With this service you can submit manuscripts, you will be able to check the content of your submission, the electronic file will be used for editorial assessment and online refereeing, and the editorial decision on the manuscript will be communicated to you.

By using this service you will guarantee fast and safe submission of your manuscript, and speed the assessment process.


Natural products and pharmacological investigation

Papers on development of Natural Products and Pharmacological investigation paper must meet specifics criterias.

We emphasize that papers on development of Natural Products and Pharmacological Investigation papers must meet the following specifics criteria:

1 - Any natural extract, fraction or compound should be fully characterized and information provided regarding origin, localization and period of the year when it was collected - specifically, the extract under study must have been fractionated and the active substances within the natural product identified;

2 - Isolation or purification techniques must be described in detail;

3 - Authors must state in their paper that the material under study is endotoxin free;

4 - Cytotoxity assays with normal cells are required;

5 - Plant Material (as well as other organisms) must be properly identified. The scientific name (in italic), the author of this name and the family must be given; it should be mentioned who identified the material. The manuscript must include references to voucher specimens of the plants (deposited in a major regional herbarium) or the material examined;

6 - Papers dealing with the biological screening of series of uncharacterized extracts of plants or other organisms will not be considered for publication in "Memórias";

7 - Pharmacological investigations of extracts require detailed extract characterization. Chromatographic profiling (e.g., HPLC profile with at least major peaks identified) should be carried out, or qualitative and quantitative information on active or typical constituents should be provided;

8 - Purely descriptive articles will not be considered. Characterization of mechanism(s) of action must be provided. "Memórias" only considers manuscripts in which conclusions are based on adequate statistics. In each case positive controls (reference compounds) should be used and the dose/activity dependence should be shown;

9 - Any studies involving human subjects should have Ethic Institutional Review Board Approval. Protocol number should be informed;

10 - When working with experimental animals, reference must be made to principles of laboratory animal care or similar regulations and to approval by the local ethical committee;

11 - Studies involving plants from the Brazilian Biodiversity must have authorization for access to genetic resource and, if it is the case, also for access to traditional knowledge associated. Authorization number must be informed.


Sequence submission

Information concerning gene sequences reported in the manuscript, must have it's public bank accession number mentioned in the manuscript. E.g. GeneBank.

The manuscript should be prepared according to the instructions to authors

Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article, including the right to reproduce the article in all form and media, shall be assigned exclusively to the Memórias. The journal will not refuse any reasonable request by authors for permission to reproduce any contribution.

  1. In case of clinical trials it’s mandatory to inform the registration number of the REBEC platform.
  2. We inform that a paper submitted to Memórias undergoes a process using the Ithenticate plagiarism checker software to prevent professional plagiarism and other forms of scholarly misconduct.
  3. All authors ensure the reported researches are not the result of misconduct such as data fabrication, falsification, plagiarism or duplication. In case of confirmed research misconduct, we will issue a retraction notice to correct the scientific record. Please refer to Singapore Statement at:
  4. Any studies involving human subjects should have Ethic Institutional Review Board Approval. Protocol number should be informed.
  5. When working with experimental animals, reference must be made to principles of laboratory animal care or similar regulations and to approval by the local ethical committee.
  6. Papers submitted to Memórias will undergo the Premium Editing of English language review made by American Journal Experts, further suggestions will enhance nonnative English writing style.
  7. A statement that the data/results of the manuscript are not plagiarism and have not been published elsewhere.


For other instructions the authors should consult and follow the most recent number of the Memórias or consult the home-page of the Memórias (, or contact the Editorial Office by phones (+55-21-2562.1222) or e-mails ( /

Format style

The manuscript should be prepared using standard word processing software and should be printed (font size 12) double-spaced throughout the text, figure captions, and references, with margins of at least 3 cm. The figures should come in the extension tiff, with a minimum resolution of 300 dpi. Tables and legends to figures must be submitted all together in a single file. Figures, must be uploaded separately as supplementary file.


Running title: with up to 40 characters (letters and spaces)
Title: with up to 250 characters
Author's names: without titles or graduations
Intitutional affiliations: author's name, section, department, lab, institution and geographic localization (city, state and country); full address of the corresponding author only.
Summary: up to 200 words (100 words in case of short communications). It should emphasize new and important aspects of the study or observations.
Key words: 3-6 items must be provided. Terms from the Medical Subject Headings (Mesh) list of Index Medicus should be used.
Sponsorships: indicating the sources of financial support and change of address
Introduction: should set the purpose of the study, give a brief summary (not a review) of previous relevant works, and state what new advance has been made in the investigation. It should not include data or conclusions from the work being reported.
Materials and Methods: should briefly give clear and sufficient information to permit the study to be repeated by others. Standard techniques need only be referenced.
Ethics: when reporting experiments on human subjects, indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) and with the Helsinki Declaration of 1975, as revised in 1983. When reporting experiments on animals, indicate whether the institution's or a national research council's guide for, or any national law on the care and use of laboratory animals was followed.
Results: should be a concise account of the new information discovered, with the least personal judgement. Do not repeat in text all the data in the tables and illustrations.
Discussion: should be limited to the significance of the new information and relate the new findings to existing knowledge. Only unavoidable citations should be included.
Acknowledgements: should be short and concise, and restricted to those absolutely necessary.

References: must be accurate. Only citations that appear in the text should be referenced. Unpublished papers, unless accepted for publication, should not be cited. Work accepted for publication should be referred to as "in press" and a letter of acceptance of the journal must be provided. Unpublished data should only be cited in the text as "unpublished observations", and a letter of permission from the author must be provided. The references at the end of the paper should be arranged in alphabetic order according to the surname of the first author.


Lutz (1910) or (Lutz 1910)

With two authors, it is:
(Lutz & Neiva 1912) or Lutz and Neiva (1912)

When there are more than two authors, only the first is mentioned:
Lutz et al. (1910) or (Lutz et al. 1910).

The titles of journals should be abbreviated according to the style used in the Index Medicus. Consult:


At the end of the paper use the following styles of references:


1. Standard journal article

1.1. Printed

Halpern SD, Ubel PA, Caplan AL 2002. Solid-organ transplantation in HIV-infected patients. N Engl J Med 25: 284-287.

1.2. On line

Halpern SD, Ubel PA, Caplan AL 2002. Solid-organ transplantation in HIV-infected patients. N Engl J Med 25: e12140307.

1.3. DOI

Zhang M, Holman CD, Price SD, Sanfilippo FM, Preen DB, Bulsara MK 2009. Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: retrospective cohort study. BMJ doi: 10.1136/bmj.a2752.

2. Organization as author

Diabetes Prevention Program Research Group 2002. Hypertension, insulin and proinsulin in participants with impaired glucose tolerance. Hypertension 40: 679-686.

3. Both personal authors and organization as author

Vallancien G, Emberton M, Harving N, van Moorselaar RJ, Alf-One Study Group 2003. Sexual dysfunction in 1,274 European men suffering from lower urinary tract symptoms. J Urol 169: 2257-2261.

4. Volume with supplement

Geraud G, Spierings EL, Keywood C 2002. Tolerability and safety of frovatriptan with short and long-term use for treatment of migraine and in comparison with sumatriptan. Headache 42 (Suppl. 2): S93-S99.

5. Article with published erratum

Malinowski JM, Bolesta S 2000. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther 22: 1151-1168. Erratum in Clin Ther 2001 23: 309.

6. Article published electronically ahead of the print version

Yu WM, Hawley TS, Hawley RG, Qu CK 2002. Immortalization of yolk sac-derived precursor cells. Blood Nov 15 100: 3828-3831. Epub 2002 Jul 5.


1. Personal author(s)

Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA 2002. Medical microbiology, 4th ed., Mosby, St. Louis, 255 pp.

2. Chapter in a book

Meltzer PS, Kallioniemi A, Trent JM 2002. Chromosome alterations in human solid tumors. In B Vogelstein, KW Kinzler (eds.), The genetic basis of human cancer, McGraw-Hill, New York, p. 93-113.

3. Conference proceedings

Harnden P, Joffe JK, Jones WG 2002. Germ cell tumours. Proceedings of the 5th Germ Cell Tumour Conference, 2001 Sep 13-15, Leeds, UK, Springer, New York, 102 pp.

4. Dissertation

Borkowski MM 2002. Infant sleep and feeding: a telephone survey of Hispanic Americans, PhD Thesis, Central Michigan University, Michigan, 78 pp.


1. In press
Tian D, Araki H, Stahl E, Bergelson J, Kreitman M 2002. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci USA, in press.

Anderson SC, Poulsen KB 2002. Anderson's electronic atlas of haematology [CD-ROM]. Lippincott Williams & Wilkins, Philadelphia.

3. Journal article on the Internet
Abood S 2002. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs [Internet] [cited 2002 Aug 12] 102. Available from:


figures and tables must be understandable without reference to the text.
Figures: presented in tiff format with a minimum of 300 dpi and photographs must be sharply focused, well contrasted, and if mounted onto a plate, the figures should be numbered consecutively with Arabic numbers. Magnification must be indicated by a line or bar in the figure, and referenced, if necessary in the caption (e.g., bar = 1 mm). Plates and line figures should either fit one column (8 cm) or the full width (16.5 cm) of the page and should be shorter than the page length to allow inclusion of the legend. Letters and numbers on figures should be of a legible size upon reduction or printing. A colour photograph illustrates the cover of each issue of the Journal and authors are invited to submit illustrations with legends from their manuscript for consideration for the cover.

Tables should supplement, not duplicate, the text and should be numbered with Roman numerals. A short descriptive title should appear above each table, with any explanations or footnotes (identified with a, b, c, etc.) below.


Technical Notes: Technical Notes should communicate rapidly single novel techniques or original technical advances. The entire note should occupy no more than three printed pages including figures and/or tables (it means around 10 double-spaced typed Word file maximum). The text must not be not divided into sections. Therefore, the state of art must be very briefly presented; results must be rapidly presented and discussed at a time. Complementary tables and figures may be published as supplementary data. References must be limited to few essential ones and cited at the end of the note, using the same format as in full papers. A brief summary and three key words must be provided.
Short communications: should communicate rapidly single results or techniques. They should occupy no more than three printed pages including figures and/or tables. They should not contain excessive references. References should be cited at the end of the paper using the same format as in full papers. A brief summary and three key words must be provided.
Alternative format: manuscripts may be submitted following the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" produced by the International Committee of Medical Journal Editors also known as the Vancouver Style. In this case, authors should follow the guidelines in the fifth edition (Annals of Internal Medicine 1997; 126: 36-47, or at the website and will be responsible for modifying the manuscript where it differs from the instructions given here, if the manuscript is accepted for publication. Authors should also follow the Uniform Requirements for any guidelines that are omitted in these Instructions.
In case of clinical trials, it’s mandatory to inform the registration number of the REBEC platform.
A statement that the data/results of the manuscript are not plagiarism and have not been published elsewhere.

Once a paper is accepted for publication, the authors must provide:

  1. an affidavit, provided by the Editorial Office, signed by all authors. Authors from different countries or institutions may sign in different sheets containing the same basic statement;
  2. a copyright assignment form, provided by the Editorial Office, signed by the corresponding author;
  3. Page charges: there will be no page charges.
  4. Proofs: one set of page proofs will be supplied for the author to check for typesetting accuracy, to be returned by the stipulated date. No changes to the original manuscript will be allowed at this stage.


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