A 52-year-old HIV-positive man (CD4 = 74 cells) presented with amaurosis and headache. The cerebrospinal fluid (CSF) had increased opening pressure and the magnetic resonance imaging (MRI) findings included irregular leptomeningeal thickening on the right frontoparietal transition and parietal sulci, with restricted diffusion, and irregular nodular gadolinium enhancement (Figures 1-3). Through CSF immunophenotyping, the final diagnosis of plasma cell dyscrasia with leptomeningeal infiltration was confirmed. HIV is a known risk factor for a wide range of plasma cell dyscrasia, from benign manifestations to aggressive multiple myeloma.11 Anuradha S, Sethi P. Plasma cell disorders in HIV infected patients: A case series. J Clin Diagn Res 2017;11(06):OR03–OR05 Meningeal involvement in multiple myeloma and plasma cell dyscrasias is extremely rare, with less than 70 reported cases.22 Laribi K, Mellerio C, Baugier A, et al. Meningeal involvement in multiple myeloma. Clin Case Rep 2015;3(02):84–87
(A-B) Precontrast fluid-attenuated inversion recovery (FLAIR) axial images showing a hyperintensity and thickening of the sulci on the right frontoparietal transition and parietal lobe. (C-D) Postcontrast FLAIR axial images better depicting intense, thick, and irregular leptomeningeal enhancement on the aforementioned regions.
(A-B) Postgadolinium volumetric fast-spin echo black-blood T1-weighted image demonstrating thick and irregular leptomeningeal enhancement on the right frontoparietal and parietal regions. (C-D) Sagittal and coronal postcontrast vessel wall imaging respectively demonstrating a nodular lesion in the same regions.
References
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1Anuradha S, Sethi P. Plasma cell disorders in HIV infected patients: A case series. J Clin Diagn Res 2017;11(06):OR03–OR05
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2Laribi K, Mellerio C, Baugier A, et al. Meningeal involvement in multiple myeloma. Clin Case Rep 2015;3(02):84–87
Publication Dates
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Publication in this collection
01 May 2023 -
Date of issue
2022
History
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Received
16 June 2022 -
Accepted
10 July 2022
