The spectrum of myopathies in the city of São Paulo

Levy, José A.; Topczewski, Abram; Mendonça, Lucia Iracema Z. de; Zatz, Mayana; Levisky, Ruth Blay

doi:10.1590/S0004-282X1976000400006

Abstracts

A review of all myopathic patients treated at the Neurologic Clinic of the Medical School of the University of São Paulo during the past 15 years is reported. A total of 466 cases were examined and distributed as follows: 56% of progressive muscular dystrophy; 31% of myasthenia gravis; 6% of polymyositis; 4% of myotonic dystrophy; and the remainder of several different diseases (central core disease, Kearns-syndrome, myotonia congenita, adynamia episodica hereditaria, diabetic myopathy and Eaton-Lambert syndrome). Enzymatic dosages, electromyography, muscle biopsy, electrocardiography and genetic counselling are also reported.

Os autores fazem uma revisão de todos os casos de miopatias tratados na Clínica Neurológica da F.M.U.S.P. durante os últimos 15 anos. Foram examinados 466 casos, assim distribuídos: 56% de distrofia muscular progressiva; 31% de miastenia grave; 6% de polimiosite; 4% de distrofia miotônica e, o restante, de várias outras moléstias (Central core disease, síndrome de Kearns, miotonia congênita, adinamia episódica hereditária, miopatia diabética e síndrome de Eaton-Lambert). São relatadas também as dosagens enzimáticas, eletromiografia, biópsia muscular, eletrocardiografia e aconselhamento genético.

The spectrum of myopathies in the City of São Paulo

José A. Levy; Abram Topczewski; Lucia Iracema Z. de Mendonça; Mayana Zatz; Ruth Blay Levisky

Center of Neurologic Investigations, Neurological Clinic of the Medical School of the University of São Paulo (Prof. Horacio M. Canelas)

SUMMARY

A review of all myopathic patients treated at the Neurologic Clinic of the Medical School of the University of São Paulo during the past 15 years is reported. A total of 466 cases were examined and distributed as follows: 56% of progressive muscular dystrophy; 31% of myasthenia gravis; 6% of polymyositis; 4% of myotonic dystrophy; and the remainder of several different diseases (central core disease, Kearns-syndrome, myotonia congenita, adynamia episodica hereditaria, diabetic myopathy and Eaton-Lambert syndrome). Enzymatic dosages, electromyography, muscle biopsy, electrocardiography and genetic counselling are also reported.

RESUMO

Os autores fazem uma revisão de todos os casos de miopatias tratados na Clínica Neurológica da F.M.U.S.P. durante os últimos 15 anos. Foram examinados 466 casos, assim distribuídos: 56% de distrofia muscular progressiva; 31% de miastenia grave; 6% de polimiosite; 4% de distrofia miotônica e, o restante, de várias outras moléstias (Central core disease, síndrome de Kearns, miotonia congênita, adinamia episódica hereditária, miopatia diabética e síndrome de Eaton-Lambert). São relatadas também as dosagens enzimáticas, eletromiografia, biópsia muscular, eletrocardiografia e aconselhamento genético.

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Clinica Neurológica Faculdade de Medicina, Universidade de São Paulo -Caixa Postal 5199 01000 São Paulo, SP Brasil.

1. EMERY, A.E.H.; WILKINSON, E. & MURPHY, E.A. Genetic counselling in. Duchenne muscular dystrophy. Proceedings 2^nd International Congress of Neuro-Ophthalmology, Montreal, 1967. Excerpta Medica Foundation, Amsterdam, 1969, v. 1, p. 106.
2. EMERY, A.E.H. & MORTON, R. Genetic counselling in lethal X-linked disorders. Acta Genet. Stat. Med. (Basel) 18:534, 1968.
3. KING ENGEL, Z.W. Classification of neuromuscular disorders. In Daniel Bergsma The Clinical Delineation of Birth Defects. Williams and Wilkins, Baltimore, 1971, pp. 18.
4. LEVISKY, R.B. Estudo genético e aconselhamento em distrofias musculares progressivas. Tese de doutoramento, Departamento de Biologia, Instituto de Biociências da USP, São Paulo, 1973.
5. MURPHY, E.A.; MUTALIK, G.S. & ELRIGE, R. The application of Bayesian methods in genetic counselling. Proceedings 3^rd International Congress of Human Genetics, Chicago, 1966.
6. MURPHY, E.A. & MUTALIK, G.S. The application of Bayesian methods in genetic counselling. Hum. Hered. 19:126, 1969.
7. ZATZ, M. Atividade da creatinina-fosfoquinase (CPK) e estudos de ligação em distrofias musculares progressivas de herança ligada ao X. Tese de doutoramento, Departamento de Biologia, Instituto de Biociências da USP, São Paulo, 1973.

Publication Dates

Publication in this collection
25 Feb 2013
Date of issue
Dec 1976

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. EMERY, A.E.H.; WILKINSON, E. & MURPHY, E.A. Genetic counselling in. Duchenne muscular dystrophy. Proceedings 2^nd International Congress of Neuro-Ophthalmology, Montreal, 1967. Excerpta Medica Foundation, Amsterdam, 1969, v. 1, p. 106.

[2] 2. EMERY, A.E.H. & MORTON, R. Genetic counselling in lethal X-linked disorders. Acta Genet. Stat. Med. (Basel) 18:534, 1968.

[3] 3. KING ENGEL, Z.W. Classification of neuromuscular disorders. In Daniel Bergsma The Clinical Delineation of Birth Defects. Williams and Wilkins, Baltimore, 1971, pp. 18.

[4] 4. LEVISKY, R.B. Estudo genético e aconselhamento em distrofias musculares progressivas. Tese de doutoramento, Departamento de Biologia, Instituto de Biociências da USP, São Paulo, 1973.

[5] 5. MURPHY, E.A.; MUTALIK, G.S. & ELRIGE, R. The application of Bayesian methods in genetic counselling. Proceedings 3^rd International Congress of Human Genetics, Chicago, 1966.

[6] 6. MURPHY, E.A. & MUTALIK, G.S. The application of Bayesian methods in genetic counselling. Hum. Hered. 19:126, 1969.

[7] 7. ZATZ, M. Atividade da creatinina-fosfoquinase (CPK) e estudos de ligação em distrofias musculares progressivas de herança ligada ao X. Tese de doutoramento, Departamento de Biologia, Instituto de Biociências da USP, São Paulo, 1973.