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Comparison of early and late percutaneous tracheotomies in adult intensive care unit

Abstracts

Background and objectives:

Percutaneous tracheotomy has become a good alternative for patients thought to have prolonged intubation in intensive care units. The most important benefits of tracheotomy are early discharge of the patient from the intensive care unit and shortening of the time spent in the hospital. Prolonged endotracheal intubation has complications such as laryngeal damage, vocal cord paralysis, glottic and subglottic stenosis, infection and tracheal damage. The objective of our study was to evaluate potential advantages of early percutaneous tracheotomy over late percutaneous tracheotomy in intensive care unit.

Methods:

Percutaneous tracheotomies applied to 158 patients in adult intensive care unit have been analyzed retrospectively. Patients were divided into two groups as early and late tracheotomy according to their endotracheal intubation time before percutaneous tracheotomy. Tracheotomies at the 0–7th days of endotracheal intubation were grouped as early and after the 7th day of endotracheal intubation as late tracheotomies. Patients having infection at the site of tracheotomy, patients with difficult or potential difficult intubation, those under 18 years old, patients with positive end-expiratory pressure above 10 cmH2O and those with bleeding diathesis or platelet count under 50,000 dL−1 were not included in the study. Durations of mechanical ventilation and intensive care stay were noted.

Results:

There was no statistical difference among the demographic data of the patients. Mechanical ventilation time and time spent in intensive care unit in the group with early tracheotomy was shorter and the difference was statistically significant (p < 0.05).

Conclusion:

Early tracheotomy shortens mechanical ventilation duration and intensive care unit stay. For that reason we suggest early tracheotomy in patients thought to have prolonged intubation.

Percutaneous tracheotomy; Early tracheotomy; Late tracheotomy


Justificativa e objetivos:

A traqueotomia percutânea tornou-se uma boa alternativa para os pacientes com previsão de intubação prolongada em unidades de terapia intensiva. Os benefícios mais importantes da traqueotomia são alta precoce da unidade de terapia intensiva e menos tempo de permanência no hospital. As complicações da intubação intratraqueal prolongada são: lesão da laringe, paralisia das pregas vocais, estenose glótica e subglótica, infecção e lesão traqueal. O objetivo deste estudo foi avaliar as potenciais vantagens da traqueotomia percutânea precoce versus traqueotomia percutânea tardia em unidade de terapia intensiva.

Métodos:

Traqueotomias percutâneas foram realizadas em 158 pacientes em unidade de terapia intensiva para adultos e analisadas retrospectivamente. Os pacientes foram alocados em dois grupos para traqueotomia precoce e tardia, de acordo com o tempo de intubação intratraqueal antes da traqueotomia percutânea. As traqueotomias consideradas precoces foram realizadas nos dias 0-7 de intubação intratraqueal e as tardias realizadas após o sétimo dia de intubação intratraqueal. Os pacientes com infecção no local da traqueotomia, intubação difícil ou potencialmente difícil, idade inferior a 18 anos, pressão positiva ao final da expiração acima de 10 cmH2O e aqueles com diátese hemorrágica ou contagem de plaquetas em 50.000 dL−1 foram excluídos do estudo. Os tempos de ventilação mecânica e internação em UTI foram registrados.

Resultados:

Não houve diferença estatística entre os dados demográficos dos pacientes. Os tempos de ventilação mecânica e de internação em unidade de terapia intensiva do grupo traqueotomia precoce foram menores e a diferença foi estatisticamente significativa (p < 0,05).

Conclusão:

Traqueotomia precoce reduz o tempo de ventilação mecânica e de internação em unidade de terapia intensiva. Portanto, sugerimos a traqueotomia precoce em pacientes com suspeita de intubação prolongada.

Traqueotomia percutânea; Traqueotomia precoce; Traqueotomia tardia


Introducción y objetivos:

La traqueotomía percutánea se ha convertido en una buena alternativa para los pacientes con previsión de intubación prolongada en unidades de cuidados intensivos (UCI). Los beneficios más importantes de la traqueotomía son el alta precoz de la UCI y menos tiempo de permanencia en el hospital. Las complicaciones de la intubación endotraqueal prolongada son: lesión de la laringe, parálisis de las cuerdas vocales, estenosis glótica y subglótica, infección y lesión traqueal. El objetivo de este estudio fue evaluar las potenciales ventajas de la traqueotomía percutánea precoz versus traqueotomía percutánea tardía en la UCI.

Métodos:

Se realizaron traqueotomías percutáneas en 158 pacientes en la UCI para adultos, siendo analizadas retrospectivamente. Los pacientes fueron divididos en 2 grupos para traqueotomía precoz y tardía, de acuerdo con el tiempo de intubación endotraqueal antes de la traqueotomía percutánea. Las traqueotomías consideradas precoces fueron realizadas en los días 0-7 de intubación endotraqueal, y las tardías, después del séptimo día de intubación endotraqueal. Los pacientes con infección en la región de la traqueotomía, intubación difícil o potencialmente difícil, con una edad inferior a 18 años, presión positiva al final de la espiración por encima de 10 cmH2O y los que tenían diátesis hemorrágica o conteo de plaquetas en 50.000 dl−1 fueron excluidos del estudio. Se registraron los tiempos de ventilación mecánica y de ingreso en la UCI.

Resultados:

No hubo diferencia estadística entre los datos demográficos de los pacientes. Los tiempos de ventilación mecánica y de ingreso en la UCI del grupo traqueotomía precoz fueron menores, y la diferencia fue estadísticamente significativa (p < 0,05).

Conclusión:

La traqueotomía precoz reduce el tiempo de ventilación mecánica y de ingreso en la UCI. Por tanto, sugerimos la traqueotomía precoz en pacientes con sospecha de intubación prolongada.

Traqueotomía percutánea; Traqueotomía precoz; Traqueotomía tardía


Introduction

Tracheotomy is one of the procedures frequently applied in intensive care units (ICUs). The most important advantages of tracheotomy are early discharge from ICU and shortening of the hospital stay of the patient. Tracheotomy is advisable for the patients who are intubated and predicted to have been on mechanical ventilation for a long period of time.1. Plummer AL, Gracey DR. Concensus conference on artificial airways in patients receiving mechanical ventilation. Chest. 1989;96:178-80.,2. Marsh HM, Gillespie DJ, Baumgartner AE. Timing of tracheostomy in the critically ill patients. Chest. 1989;96:190-3. Prolonged endotracheal intubation has complications including laryngeal damage, vocal cord paralysis, glottic and subglottic stenosis, infection, tracheal damage (tracheomalasia, tracheal dilatation and tracheal stenosis), etc.3. Whited RE. A prospective study of laryngotracheal sequelae in term intubation. Laryngoscope. 1984;94:367-77.,4. Atinkaya C, Şahin E, Kutlay H, et al. The role of dynamic stents in postintubation tracheal stenosis. Klin J Med Sci. 2003;23:310-8.

While surgical tracheotomy was the single alternative until 1969, percutaneous tracheotomy (PT) has been a new alternative after the first half of 80th. Tracheotomy having a lot of advantages is a good alternative for endotracheal intubation in ICUs.5. Akinci İŎ, Tuğrul S, Ŏzcan P, et al. Comparison of percutaneous dilatational and forceps guided tracheostomy techniques. Türk Anest Rean Cem Mecmuas. 2001;29:547-50.

The main concern is when and to which patients apply the tracheotomy. In 1998 a review notified weak proof about the effect of timing of tracheotomy on mechanical ventilation time and preventing the airway damage in critical patients.6. Maziak DE, Meade MO, Todd TR. The timing of tracheotomy: a systematic review. Chest. 1998;114:605-9. Some studies show that early tracheotomy shortens mechanical ventilation time, ICU and hospital stay times and results in less damage to the airways.7. Rumbak MJ, Newton M, Truncale T, et al. A prospective, randomized, study comparing early percutaneous dilatational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med. 2004;32:1689-94.,8. Rodriguez JL, Steinberg SM, Luchetti FA, et al. Early tracheostomy for primary airway management in the surgical critical care setting. Surgery. 1990;108:655-9.

Old references propose tracheotomy to patients thought to be intubated for more than 21 days. But today it is advisable to evaluate the patient between the second and tenth days of intubation and consider tracheotomy for them who will require intubation for more than 14 days. Early tracheotomy is beneficial for some special circumstances such as patients with polytrauma, head trauma and low Glaskow Coma Scale (GCS). Ear Nose Throat specialists also advise early tracheotomy for prevention of laryngeal damage.9. Durbin Jr CG. Tracheostomy: why, when, and how? Respir Care. 2010;55:1056-68.

We aimed to evaluate the effect of early application of PT in our study and see the advantages, if any, over late PT regarding mechanical ventilator and hospital length of stay of the patient.

Methods

Patients hospitalized in Vakif Gureba Research Hospital Intensive Care Unit between May 2007 and August 2010 who were undergone elective tracheotomy because of prolonged endotracheal intubation were included in the study and were examined retrospectively. Total number of the patients was 158, with the age range of 18–98 years. The First-degree relative of each patient was informed about the procedure and informed consent had been taken from them. Patients were divided into two groups. The patients undergone early tracheotomy (tracheotomy between the 0 and 7th days of endotracheal intubation) named as Group I and those under-gone late tracheotomy (tracheotomy after the 7th day of endotracheal intubation) as Group II. Patients with infection on the site of tracheotomy, bleeding diathesis or platelet count less than 50,000 dL−1, those with known or suspected difficult airway, patients under 18 years old and those with PEEP more than 10 cm H2O were excluded from the study.

Demographic data such as age, sex, body mass and height were noted, as well as ICU hospitalization reason, the day of tracheotomy, average mechanical ventilation time after tracheotomy and total mechanical ventilation duration.

All the patients had been routinely monitorized with ECG, NIBP and pulse oxymetry. All patients had received propofol 3mgkg−1, fentanyl 2μgkg−1, midazolam 0.03 mg kg−1 and vecuronium 0.1 mg kg−1 iv for sedation. The patients were pre-oxygenized for 15 min and during the procedure with 100% oxygen.

Percutaneous tracheotomy kit (Portex®) tracheotomy canulla with internal diameter of 8 mm had been used for the patients of both groups. The site of tracheotomy had been controlled for any haemorrhage, infection, decannulation during the hospital stay.

Statistical analysis was made via SPSS 15.0 program. Kolmogorov–Smirnov test was used for assessment of normal distribution. Regarding the comparison of quantitative data between the groups Independent Samples t-test was used for evaluation of data with normal distribution and Mann Whitney U test for data without normal distribution. Paired Samples t-test was used for evaluation of the data with normal distribution and Wilcoxon test for the data with-out normal distribution. χ2 test was used for comparison of qualitative data. The results in confidence interval of 95% and with p < 0.05 were considered statistically significant.

Results

158 patients were included in the study. 101 of them were males and 57 females. Males and female ratios with early tracheotomy were respectively 64.3% and 35.7%, while with late tracheotomy were respectively 62.8% and 37.2%. There was no statistically significant difference between two groups according to the sexes of the patients (p > 0.05). Early PT was applied to 115 patients, while late PT to 43 patients. There was no statistically significant difference between two groups according to the demographic data (p > 0.05) (Tables 1 and 2).

Table 1
Sex distribution of patients with early and late tracheotomy.
Table 2
Age and BMI distribution of tracheotomies.

There was no statistically significant difference between two groups regarding hospitalization indication into the ICU (p > 0.05) (Table 3).

Table 3
Distribution of tracheotomy according to ICU acceptance indication.

Mechanical ventilation time after tracheotomy was long in Group II compared with Group I. This difference was statistically significant (p < 0.05) (Table 4).

Table 4
Mechanical ventilation time and ICU stay duration after early and late tracheotomy.

ICU stay duration after tracheotomy was long in Group II compared with Group I. This difference was statistically significant (p < 0.05) (Table 4).

Discussion

While it was advisable to apply tracheotomy before 21st day of endotracheal intubation in the past, Durbin et al.9. Durbin Jr CG. Tracheostomy: why, when, and how? Respir Care. 2010;55:1056-68. have proposed to evaluate the patient for tracheotomy between days 2–10 of mechanical ventilation and perform tracheotomy for patients thought to be left intubated for more than 14 days, especially for some selected patient groups such as major polytrauma, low GCS and head trauma.

Zagli et al.1010 . Zagli G, Linden M, Spina R, et al. Early tracheostomy in intensive care unit: a retrospective study of 506 cases of videoguided Ciaglia Blue Rhino tracheostomies. J Trauma. 2010;68:367-72. have compared effects of early and late tracheotomies in 506 patients. Early tracheotomy was defined as tracheotomy in the first three days of endotracheal intubation in this study and mechanical ventilation duration and hospital length of stay were shorter in the early tracheotomy group.

However, there are some studies that show no difference between early and late tracheotomy. Sugerman et al.1111 . Sugerman HJ, Wolfe L, Pasquale MD, et al. Multicenter, randomized, prospective trial of early tracheostomy. J Trauma. 1997;43:741-7. have shown no difference between early and late tracheotomy regarding ICU length of stay. They performed early tracheotomy between days 3–5 and late tracheotomy between days 10 and 14 of endotracheal intubation. Blot et al.1212 . Blot F, Similowski T, Trouillet JL, et al. Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med. 2008;34:1779-87. compared two groups of patients with early tracheotomy versus prolonged intubation and found no data favoring early tracheotomy, so proposed not to apply early tracheotomy besides selected patient groups.

We have found shorter hospital length of stay in the patients with early tracheotomy in our study. Mean hospital length of stay for early and late tracheotomy groups were 17.4 and 31.0 days respectively. The difference was statistically significant.

Yavas et al.1313 . Yavas S, Yagar S, Mavioglu L, et al. Tracheostomy: how and when should it be done in cardiovascular surgery ICU? J Card Surg. 2009;24:11-8. have compared surgical and PT and concluded that both methods can be used in ICU but with lower infection rate with early tracheotomy. Lesnik et al.1414 . Lesnik I, Rappaport W, Fulginiti J, et al. The role of early tracheostomy in blunt, multiple organ trauma. Am Surg. 1992;58:346-9. showed that patients with early tracheotomy have significantly lower mechanical ventilator stay compared with late tracheotomy in the study where they applied tracheotomy on the fourth day of endotracheal intubation to the early tracheotomy group. These findings are coherent with the results of our study.

Both percutaneous and surgical tracheotomies have complications such as haemorrhage, subcutaneous emphysema, tracheal damage, wound infection, pneumothorax and pneumomediastinum.1515 . Kansu L, Aydin E, Avci S. A percutaneous tracheotomy complication: tracheal stenosis: case report. Turkiye Klinikleri J Med Sci. 2008;28:773-7. Holdgaard et al.1616 . Holdgaard HO, Pedersen J, Jensen RH, et al. Percutaneous dilatational tracheostomy versus conventional surgical tracheostomy. A clinical randomised study. Acta Anaesthesiol Scand. 2000;44:1029. have compared surgical and percutaneous tracheotomies and illustrated superiority of percutaneous technique. Freidman et al.1717 . Friedman Y, Fildes J, Mizock B, et al. Comparison of percutaneous and surgical tracheostomies. Chest. 1996;1108:480-5. displayed complication rates for percutaneous and surgical tracheotomies as 12% and 42% respectively. As a result of these data PT has gradually become more preferable method. Compared with surgical tracheotomy, PT reduces expenditure because of shortening of time spent in operation room and sparing operation room crew need.1818 . Bacchetta MD, Girardi LN, Southard EJ, et al. Comparison of open versus bedside percutaneous dilatational tracheostomy in the cardiothoracic surgical patient: outcomes and financial analysis. Ann Thorac Surg. 2005;79:1879-85.,1919 . Barba CA, Angood PB, Kauder DR, et al. Bronchoscopic guidance makes percutaneous tracheostomy a safe, cost-effective, and easy-to-teach procedure. Surgery. 1995;118:879-83.

Conclusions

Early PT shortens mechanical ventilation duration time and ICU length of stay.

References

  • 1
    Plummer AL, Gracey DR. Concensus conference on artificial airways in patients receiving mechanical ventilation. Chest. 1989;96:178-80.
  • 2
    Marsh HM, Gillespie DJ, Baumgartner AE. Timing of tracheostomy in the critically ill patients. Chest. 1989;96:190-3.
  • 3
    Whited RE. A prospective study of laryngotracheal sequelae in term intubation. Laryngoscope. 1984;94:367-77.
  • 4
    Atinkaya C, Şahin E, Kutlay H, et al. The role of dynamic stents in postintubation tracheal stenosis. Klin J Med Sci. 2003;23:310-8.
  • 5
    Akinci İŎ, Tuğrul S, Ŏzcan P, et al. Comparison of percutaneous dilatational and forceps guided tracheostomy techniques. Türk Anest Rean Cem Mecmuas. 2001;29:547-50.
  • 6
    Maziak DE, Meade MO, Todd TR. The timing of tracheotomy: a systematic review. Chest. 1998;114:605-9.
  • 7
    Rumbak MJ, Newton M, Truncale T, et al. A prospective, randomized, study comparing early percutaneous dilatational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med. 2004;32:1689-94.
  • 8
    Rodriguez JL, Steinberg SM, Luchetti FA, et al. Early tracheostomy for primary airway management in the surgical critical care setting. Surgery. 1990;108:655-9.
  • 9
    Durbin Jr CG. Tracheostomy: why, when, and how? Respir Care. 2010;55:1056-68.
  • 10
    Zagli G, Linden M, Spina R, et al. Early tracheostomy in intensive care unit: a retrospective study of 506 cases of videoguided Ciaglia Blue Rhino tracheostomies. J Trauma. 2010;68:367-72.
  • 11
    Sugerman HJ, Wolfe L, Pasquale MD, et al. Multicenter, randomized, prospective trial of early tracheostomy. J Trauma. 1997;43:741-7.
  • 12
    Blot F, Similowski T, Trouillet JL, et al. Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med. 2008;34:1779-87.
  • 13
    Yavas S, Yagar S, Mavioglu L, et al. Tracheostomy: how and when should it be done in cardiovascular surgery ICU? J Card Surg. 2009;24:11-8.
  • 14
    Lesnik I, Rappaport W, Fulginiti J, et al. The role of early tracheostomy in blunt, multiple organ trauma. Am Surg. 1992;58:346-9.
  • 15
    Kansu L, Aydin E, Avci S. A percutaneous tracheotomy complication: tracheal stenosis: case report. Turkiye Klinikleri J Med Sci. 2008;28:773-7.
  • 16
    Holdgaard HO, Pedersen J, Jensen RH, et al. Percutaneous dilatational tracheostomy versus conventional surgical tracheostomy. A clinical randomised study. Acta Anaesthesiol Scand. 2000;44:1029.
  • 17
    Friedman Y, Fildes J, Mizock B, et al. Comparison of percutaneous and surgical tracheostomies. Chest. 1996;1108:480-5.
  • 18
    Bacchetta MD, Girardi LN, Southard EJ, et al. Comparison of open versus bedside percutaneous dilatational tracheostomy in the cardiothoracic surgical patient: outcomes and financial analysis. Ann Thorac Surg. 2005;79:1879-85.
  • 19
    Barba CA, Angood PB, Kauder DR, et al. Bronchoscopic guidance makes percutaneous tracheostomy a safe, cost-effective, and easy-to-teach procedure. Surgery. 1995;118:879-83.

Publication Dates

  • Publication in this collection
    Nov-Dec 2014

History

  • Received
    30 June 2013
  • Accepted
    19 Aug 2013
Sociedade Brasileira de Anestesiologia R. Professor Alfredo Gomes, 36, 22251-080 Botafogo RJ Brasil, Tel: +55 21 2537-8100, Fax: +55 21 2537-8188 - Campinas - SP - Brazil
E-mail: bjan@sbahq.org