Abstract
Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.
poliovaccine; thermostabilizers
Study on thermostabilizers for trivalent oral poliomyelitis vaccine
M. L. F. Leal1
F. J. C. Lopes1
M. H. G. Carvalho1
H. A. B. Moura1
S. A. F. Soares1
Fundação Oswaldo Cruz, Bio-Manguinhos, Depto 1. Laboratório de Poliomielite, Rio de Janeiro, Brasil
Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.
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Publication Dates
-
Publication in this collection
04 June 2009 -
Date of issue
Sept 1990
