Acessibilidade / Reportar erro

Stress management in Medicine

SUMMARY

Stress and burnout can result in errors, reduction in patient safety, and decreased productivity. They can cause absenteeism, depression, destructive behavior, alcohol, drug abuse, and even suicide. Several factors lead to professional stress, many of which are out of one’s control, thus making intervention impossible. Physicians often neglect their health and ignore stress and burnout. They often deny the existence of stress as a way of adapting to it, which is an ineffective method of coping with this problem that can lead to negative coping strategies. For managing stress and burnout, it is paramount to recognize situations/conditions that may trigger them, identify their signs, and invest in well-being strategies. In this article, well-being promotion is addressed with a focus on strategies that can be used at the individual level. Topics such as stress management and resilience should be valued in medical training and profession. As long as they form a part of the “hidden curriculum”, well-being will continue to be undervalued, when in fact it should be seen as fundamental to the health of professionals and patients.

KEYWORDS:
Mental health; Occupational stress; Psychological burnout; Psychological resilience; Physicians; Medicine

Stress does not discriminate when it comes to occupation, career length, or seniority and no health professional is immune to it11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
. Stress and burnout can result in errors (since they affect attention, concentration, and decision-making ability), reduction in patient safety, and decreased productivity. They can cause absenteeism, depression, destructive behavior, alcohol, and drug abuse, and even suicide22. Shapiro SL, Shapiro DE, Schwartz GE. Stress management in medical education: a review of the literature. Acad Med. 2000;75(7):748-59. https://doi.org/10.1097/00001888-200007000-00023
https://doi.org/10.1097/00001888-2000070...
,33. Harolds JA. Quality and safety in healthcare, Part LXI: Burnout and Wellness in residents. Clin Nucl Med. 2020;45(9):679-80. https://doi.org/10.1097/RLU.0000000000002886
https://doi.org/10.1097/RLU.000000000000...
.

Stress is a complex phenomenon composed of three key elements: source (stressors), effects, and individual differences44. Iliceto P, Pompili M, Spencer-Thomas S, Ferracuti S, Erbuto D, Lester D, et al. Occupational stress and psychopathology in health professionals: an explorative study with the multiple indicators multiple causes (MIMIC) model approach. Stress. 2013;16(2):143-52. https://doi.org/10.3109/10253890.2012.689896
https://doi.org/10.3109/10253890.2012.68...
.

Stressors can be classified as being extrinsic and intrinsic11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
. Extrinsic factors include the following: high goals at work/college; excessive work/study hours; lack of resources required to do a good job; lack of socialization, good relationships, and support at work; sexual/racial discrimination; inadequate time for sleep; lack of proper feedback; lack of work recognition and autonomy; conflicts between personal values and organizational values; excessive bureaucracy; increased responsibility (especially for residents); and negative events in one’s personal life. Intrinsic factors include the following: being extremely self-demanding (perfectionism); denying vulnerability (denying stress or having difficulty recognizing it); being overly meticulous, idealistic, controlling, and/or self-critical; lack of determination; low self-esteem and self-confidence; pessimism; and feeling that one’s work is meaningless11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,33. Harolds JA. Quality and safety in healthcare, Part LXI: Burnout and Wellness in residents. Clin Nucl Med. 2020;45(9):679-80. https://doi.org/10.1097/RLU.0000000000002886
https://doi.org/10.1097/RLU.000000000000...
,55. Gazelle G, Liebschutz JM, Riess H. Physician burnout: coaching a way out. J Gen Intern Med. 2015;30(4):508-13. https://doi.org/10.1007/s11606-014-3144-y
https://doi.org/10.1007/s11606-014-3144-...
,66. Harolds JA. Quality and safety in healthcare, Part LXVI: contributing causes of poor well-being in medical students. Clin Nucl Med. 2021;46(2):133-5. https://doi.org/10.1097/RLU.0000000000002969
https://doi.org/10.1097/RLU.000000000000...
. Traits such as compulsion, guilt, and self-denial (reflected as self-care negligence) can contribute to success in medical training. However, eventually, they become harmful55. Gazelle G, Liebschutz JM, Riess H. Physician burnout: coaching a way out. J Gen Intern Med. 2015;30(4):508-13. https://doi.org/10.1007/s11606-014-3144-y
https://doi.org/10.1007/s11606-014-3144-...
. Some personality types are risk factors for stress, such as neurotic personalities. Individuals with this personality type are usually nervous, oversensitive, tense, concerned, and have low frustration tolerance77. Tyssen R, Dolatowski FC, Røvik JO, Thorkildsen RF, Ekeberg O, Hem E, et al. Personality traits and types predict medical school stress: a six-year longitudinal and nationwide study. Med Educ. 2007;41(8):781-7. https://doi.org/10.1111/j.1365-2923.2007.02802.x
https://doi.org/10.1111/j.1365-2923.2007...
.

Stress becomes harmful when the person realizes that they are not able to deal with excessive demands and when adaptive responses become counterproductive, leading to decreased performance11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
. Stress also affects the learning process because it has a negative impact on memory. Stressful situations are internally evaluated for damage, loss, threat, or challenge based on the person’s capabilities and resources when facing such situations. The confrontation process comes from the individual’s efforts to balance demands with their available internal resources. In addition, the emotional experience of stress is influenced by the cognitive assessment of demand versus coping capacity. This explains why some stressors are seen as positive (challenges), while others are seen as negative (threat or damage). Stress is influenced by personal characteristics including emotions, self-esteem, and resilience. People can experience completely different emotions from a stressful situation, even when the external stressors are identical88. Ng R, Chahine S, Lanting B, Howard J. Unpacking the Literature on Stress and Resiliency: A Narrative Review Focused on Learners in the Operating Room. J Surg Educ. 2019;76(2):343-53. https://doi.org/10.10167j.jsurg.2018.07.025
https://doi.org/10.10167j.jsurg.2018.07....
.

Longstanding, unresolved stress can result in burnout. This occurs when meaningful and challenging work becomes unpleasant and no longer brings satisfaction, when enthusiasm gives way to emotional exhaustion, and when effectiveness turns to inefficiency. Physicians experiencing burnout have reduced capacity to feel compassion and to practice empathy, in addition to having less time and ability to support their patients11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,99. Bridgeman PJ, Bridgeman MB, Barone J. Burnout syndrome among healthcare professionals. Am J Heal Pharm. 2018;75(3):147-52. https://doi.org/10.2146/ajhp170460
https://doi.org/10.2146/ajhp170460...
.

Many physicians neglect their health and ignore stress and burnout. They often deny stress as a way of adapting to it, which is an ineffective method of coping with this problem that can lead to negative coping strategies. Some physicians simply have trouble realizing they are under stress and suffering from burnout, which is also harmful1010. Sigsbee B, Bernat JL. Physician burnout: a neurologic crisis. Neurology. 2014;83(24):2302-6. https://doi.org/10.1212/ WNL.0000000000001077
https://doi.org/10.1212/ WNL.00000000000...
.

Therefore, for managing stress and burnout, it is paramount to recognize situations/conditions that may trigger them (to avoid them when possible), as well as identifying their signs as shown below11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,99. Bridgeman PJ, Bridgeman MB, Barone J. Burnout syndrome among healthcare professionals. Am J Heal Pharm. 2018;75(3):147-52. https://doi.org/10.2146/ajhp170460
https://doi.org/10.2146/ajhp170460...
.

  • Stress characteristics: isolation, retraction/introversion, rumination, procrastination, anger, crying easily, self-depreciation, excessive caution, lack of enthusiasm, reluctance to ask for help, inflexibility, difficulty in taking rest breaks, difficulty in concentration, irritability.

  • Burnout characteristics: excessive emotional exhaustion, cynicism, loss of empathy, detachment (treating patients coldly and like objects), indifference and apathy towards work, feelings of failure and incompetence (even if they are not real), not feeling fulfilled at work.

Unfortunately, a lot of stressors are out of one’s control making intervention impossible. Thus, to manage stress, efforts should be focused on controllable elements that can promote resilience and improve global well-being11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
https://www.nhs.uk/conditions/stress-anx...
.

When experiencing a stressful situation, self-reflection and self-awareness are fundamental, either individually, or with the help of friends, co-workers, a mentor, or a mental health professional11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,55. Gazelle G, Liebschutz JM, Riess H. Physician burnout: coaching a way out. J Gen Intern Med. 2015;30(4):508-13. https://doi.org/10.1007/s11606-014-3144-y
https://doi.org/10.1007/s11606-014-3144-...
. Self-awareness means being aware of one’s thoughts, emotions, and behaviors. It is essential for developing cognitive flexibility, which is the ability to mentally adapt to challenging situations, to accept that mistakes can happen, and to deal with uncertainties1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
https://doi.org/10.1016/j.bjoms.2018.08....
.

The following questions can help in the practice of self-reflection and self-awareness: How have I faced difficult situations and succeeded in dealing with them? What has worked out, despite these difficulties? What was decisive for overcoming these situations? Why haven’t I dealt so well with other situations (e.g., skipping meals, not having enough time to rest)? What were the difficulties (e.g., lack of time management and establishment of priorities)? Which signs have demonstrated that I am not coping well with a situation (e.g., feeling frustrated, tired, irritated, having headaches and/or muscle contractures)11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
,55. Gazelle G, Liebschutz JM, Riess H. Physician burnout: coaching a way out. J Gen Intern Med. 2015;30(4):508-13. https://doi.org/10.1007/s11606-014-3144-y
https://doi.org/10.1007/s11606-014-3144-...
? Some people believe that keeping a diary may be useful for self-reflection1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
https://doi.org/10.1016/j.bjoms.2018.08....
.

Using the wheel of life tool is an interesting exercise to assist in the process of self-awareness and in the development of strategies to establish an action plan for lessening the impact of stress on the person. A wheel of life is made of pre-defined domains that represent ways of describing life. Each domain should be classified according to its degree of satisfaction. For example, if the social life domain is classified as 7, its numbers from 0 to 7 are colored. Ranking all of the domains will result in a complete overview of the wheel of life. In this way, the focus will be on those areas that need to be improved and what can be done to improve them55. Gazelle G, Liebschutz JM, Riess H. Physician burnout: coaching a way out. J Gen Intern Med. 2015;30(4):508-13. https://doi.org/10.1007/s11606-014-3144-y
https://doi.org/10.1007/s11606-014-3144-...
. Within the health domain, there are issues such as the adequate amount of sleep, nutrition, and exercise1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
https://doi.org/10.1016/j.bjoms.2018.08....
. For resident physicians, in particular, the wheel of life is usually found to be unbalanced, because their investment in professional growth affects other areas related to family, social life, physical and mental health, spirituality, and finances1313. Anagnostopoulos F, Demerouti E, Sykioti P, Niakas D, Zis P. Factors associated with mental health status of medical residents: a model-guided study. J Clin Psychol Med Settings. 2015;22(1):90-109. https://doi.org/10.1007/s10880-014-9415-2
https://doi.org/10.1007/s10880-014-9415-...
.

It has been noted that resilience is fundamental to be able to deal with stress. Resilience is the ability to overcome and recover from adversities, to bend rather than break, and to persevere and adapt when circumstances are difficult. It is the ability to develop and to adapt to challenges and to discover new ways to move forward without negative consequences for individual well-being. Improving resilience results in learning how to deal with stress in a way that protects mental health. A person with good resilience has the ability not only to survive troubled times but also to boost personal and professional development11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
. Optimism and flexibility are important for resilience88. Ng R, Chahine S, Lanting B, Howard J. Unpacking the Literature on Stress and Resiliency: A Narrative Review Focused on Learners in the Operating Room. J Surg Educ. 2019;76(2):343-53. https://doi.org/10.10167j.jsurg.2018.07.025
https://doi.org/10.10167j.jsurg.2018.07....
. Some techniques that have been proven to increase the level of optimism are sharing good news, reflecting on daily successes and achievements, and showing people gratitude whether personally or in writing. In addition, other factors that can contribute to greater resilience are a sense of purpose and meaning to life, high-quality leisure time, and a sense of humor1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
https://doi.org/10.1016/j.bjoms.2018.08....
.

Actions that provide well-being should be promoted to avoid stress. Below are five key attitudes for promoting well-being11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
https://doi.org/10.1136/archdischild-201...
:

  1. Connect: It is important to have support from family, friends, co-workers, and/or mentors. Reliable social relations (family, friends) bring a sense of safety so that individuals can be “themselves”, providing a stress outlet11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
    https://doi.org/10.1136/archdischild-201...
    ,1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
    https://doi.org/10.1016/j.bjoms.2018.08....
    . Good relationships help build a sense of belonging and create opportunities to share positive experiences and to provide and receive emotional support. Some recommendations could be: have dinner with the family; meet friends you haven’t seen in a while; have lunch with a co-worker; have a conversation or play a game with friends/family instead of watching TV; visit a friend or family member who needs help; volunteer; make video calls, and avoid keeping in touch only through text messages on social media channels1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
    https://www.nhs.uk/conditions/stress-anx...
    ,1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    . In general, physicians neither support each other nor provide positive feedback (acknowledgments, compliments) to co-workers. In this sense, a change of attitude contributes to improving the quality of relationships in the workplace1010. Sigsbee B, Bernat JL. Physician burnout: a neurologic crisis. Neurology. 2014;83(24):2302-6. https://doi.org/10.1212/ WNL.0000000000001077
    https://doi.org/10.1212/ WNL.00000000000...
    .

  2. Be active: Physical activity reduces the intensity of emotions related to stress and increases self-esteem. Any physical activity is better than none. Physical exercise can release adrenaline (such as aerobic activities) or bring relaxation (such as eastern body-mind practices). People should try to be active every day, turning it into a habit. Doing exercise while listening to music or a podcast, in a group, or with the help of applications, helps to maintain motivation11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
    https://doi.org/10.1136/archdischild-201...
    ,1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
    https://www.nhs.uk/conditions/stress-anx...
    ,1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    .

  3. Be aware: People should use mindfulness to develop an awareness of their internal, emotional, and cognitive processes, as well as of their environment. This practice identifies stressors by their early signs and helps to balance emotions. It also ensures that actions are taken that optimize well-being before it is too late11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
    https://doi.org/10.1136/archdischild-201...
    ,1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
    https://doi.org/10.1016/j.bjoms.2018.08....
    ,1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    . An important part of mindfulness is the reconnection with present thoughts and feelings. Being aware of our thoughts makes it easier to analyze their influence on our behavior1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    . By promoting professional and personal development, we understand more deeply our life history, experiences, personality, and how we see ourselves in comparison to how others see us. All of these factors influence our behavior and understanding their results in better management1212. Murden F, Bailey D, Mackenzie F, Oeppen RS, Brennan PA. The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals. Br J Oral Maxillofac Surg. 2018;56(9):786-90. https://doi.org/10.1016/j.bjoms.2018.08.012
    https://doi.org/10.1016/j.bjoms.2018.08....
    . Many free applications assist in mindfulness practice, some of which are recommended by the United Kingdom National Health Service (NHS)1515. NHS. Mental health apps. [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/apps-library/category/mental-health/
    https://www.nhs.uk/apps-library/category...
    .

  4. Learn new things: Having a proactive attitude to seeking out challenges reduces stress. Learning new things improves self-confidence and self-esteem, and helps to build a sense of purpose and connections with other people. Some examples are: learning a new sport, a new language, or a new hobby, cooking a new dish, trying to do things on your own (like fixing a bicycle or hemming pants), and taking on new responsibilities at work. Using mistakes as learning experiences help to overcome their negative effects on a person’s well-being11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
    https://doi.org/10.1136/archdischild-201...
    ,1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
    https://www.nhs.uk/conditions/stress-anx...
    ,1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    .

  5. Help others: Devoting time and compassion to co-workers and patients prevents burnout because it creates positive feelings and a sense of reward. It also builds a sense of purpose and helps a person to connect with people. Other ways of helping include spending time with friends or relatives who need support or company, and asking how a friend, a co-worker, or relative is, and listening to them11. Suri S, Nash E. Resilience: surviving and thriving in the paediatric workplace. Arch Dis Child Educ Pract Ed. 2018;103(6):291-5. https://doi.org/10.1136/archdischild-2017-313554
    https://doi.org/10.1136/archdischild-201...
    ,1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
    https://www.nhs.uk/conditions/stress-anx...
    ,1414. NHS. 5 steps to mental wellbeing. 2019 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/improve-mental-wellbeing/
    https://www.nhs.uk/conditions/stress-anx...
    .

Finally, it is important to emphasize that unhealthy habits should not be used (use of alcohol, cigarettes, and caffeine) as a means of coping with stress1111. NHS. 10 stress busters. 2018 [cited on 2020 Sep 11]. Available from: https://www.nhs.uk/conditions/stress-anxiety-depression/reduce-stress/
https://www.nhs.uk/conditions/stress-anx...
.

Topics such as stress management and resilience should be valued in medical training and profession1616. Wilson PM, Batra M, Kemper KJ, Mahan JD, Staples BB, Serwint JR. Physician well-being. Pediatr Rev. 2019;40(Suppl 1):12-20. https://doi.org/10.1542/pir.2018-0329
https://doi.org/10.1542/pir.2018-0329...
. As long as they form part of the “hidden curriculum”, well-being will continue to be undervalued, when in fact it should be seen as fundamental to the health of professionals and patients.

  • Funding: none.

REFERENCES

Publication Dates

  • Publication in this collection
    27 Aug 2021
  • Date of issue
    Mar 2021

History

  • Received
    01 Oct 2020
  • Accepted
    18 Oct 2020
Associação Médica Brasileira R. São Carlos do Pinhal, 324, 01333-903 São Paulo SP - Brazil, Tel: +55 11 3178-6800, Fax: +55 11 3178-6816 - São Paulo - SP - Brazil
E-mail: ramb@amb.org.br