Management of mucous membrane pemphigoid with dapsone plus weekly steroid injections in a young patient: a case report

Tratamento de penfigóide membranoso mucoso com dapsona e injeções semanais de esteróide em um paciente jovem: relato de caso

CASE REPORT

Management of mucous membrane pemphigoid with dapsone plus weekly steroid injections in a young patient: a case report

Tratamento de penfigóide membranoso mucoso com dapsona e injeções semanais de esteróide em um paciente jovem: relato de caso

Gurumoorthy Kaarthikeyan^I; N.D. Jayakumar^I; Ogoti Padmalatha^I; Joseph M. Thachil^I; Sheeja Varghese^I; Thiruvengadam Chandrasekar^II

^IDepartment of Periodontics, Saveetha Dental College and Hospitals, Chennai-77, India

^IIDepartment of Oral Pathology, Saveetha Dental College and Hospitals, Chennai-77, India

^{Correspondence}

ABSTRACT

PURPOSE: Mucous Membrane Pemphigoid (MMP) is an autoimmune subepithelial blistering disorder usually affecting older individuals. This paper describes the pharmacological management of MMP in a young patient.

CASE DESCRIPTION: A 23 year-old woman showed erythematous ulcerative gingiva in the maxillary palatal region and around the retromolar region. A perilesional excisional biopsy was done, and the histologic and immunohistochemical analysis confirmed the clinical diagnosis of MMP as the cause of desquamative gingivitis in this patient. The patient was treated with topical steroids plus daily Dapsone 100 mg and weekly steroid injections (40 mg). The lesions began to resolve after 12 weeks of therapy.

CONCLUSION: This case of MMP in a young female patient was effectively managed with a combination therapy of topical steroids, Dapsone and steroid injections.

Key words: Pemphigoid; topical steroids; dapsone; steroid injections; immunofluorescence

RESUMO

OBJETIVO: O penfigóide membranoso mucoso (PMM) é uma desordem autoimume subeptelial bolhosa que geralmente afeta indivíduos mais velhos. Este relato de caso descreve a abordagem farmacológica do PMM em uma paciente jovem.

DESCRIÇÃO DO CASO: Uma paciente do sexo feminino, com 23 anos de idade, apresentava a gengiva eritematosa e ulcerada na região palatina e na região retromolar. A biópsia excisional total foi realizada e as análises histológica e de imuno-histoquímica confirmaram o diagnóstico clínico de PMM como causa da gengivite descamativa nesta paciente. A paciente foi tratada com esteróides tópicos, Dapsona 100 mg diariamente e injeções de esteróides mensais (40 mg). A resolução das lesões se iniciou após 12 semanas de terapia medicamentosa.

CONCLUSÃO: Este caso de PMM em uma paciente jovem foi efetivamente tratado com uma terapia combinada de esteróides tópicos, Dapsona e injeções de esteróides.

Palavras-chave: Penfigóide membranoso mucoso; esteróides tópicos; dapsona; injeções de esteróide; imunofluorescência

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Received: October 3, 2009

Accepted: November 16, 2009

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Publication Dates

• Publication in this collection
  26 Aug 2011
• Date of issue
  2010

History

• Received
  03 Oct 2009
• Accepted
  16 Nov 2009