Redução na concentração de glicose no cérebro de camundongos inoculados com liquido cefalorraquiano de pacientes com esclerose lateral amiotrófica

Godoy, J. M.; Skacel, M.; Lima, J M. B.; Andrade, C. M.

doi:10.1590/S0004-282X1990000400012

Resumos

Os autores analisam, por técnica cromatográfica, as concentrações de glicose no cérebro de camundongos inoculados com L.CR de 4 pacientes com ELA. Foi encontrada redução na, concentração do carboidrato no material estudado, sugerindo a presença de fator extrínseco veiculado pelo LCR.

Using chromatographic analysis the authors studied glucose concentration in the brain of Swiss mice inoculated with CSF of four patients with amyotrophic lateral sclerosis. They found reduction in the levels of glucose, suggesting the existence of an exogenous factor tnansfered by CSF.

J. M. Godoy^I; M. Skacel^II; J M. B. Lima^III; C. M. Andrade^IV

^IProfessor Adjunto de Neurologia da Universidade do Estado do Rio de Janeiro (UERJ) - Trabalho realizado no Departamento de Microbiologia da Universidade Federal do Rio de Janeiro (UFRJ)

^IIProfessor Agsistente de Neurologia da UERJ - Trabalho realizado no Departamento de Microbiologia da Universidade Federal do Rio de Janeiro (UFRJ)

^IIIProfessor Adjunto de Neurologia da UFRJ - Trabalho realizado no Departamento de Microbiologia da Universidade Federal do Rio de Janeiro (UFRJ)

^IVProfessor Titular de Microbiologia da UFRJ - Trabalho realizado no Departamento de Microbiologia da Universidade Federal do Rio de Janeiro (UFRJ)

RESUMO

Os autores analisam, por técnica cromatográfica, as concentrações de glicose no cérebro de camundongos inoculados com L.CR de 4 pacientes com ELA. Foi encontrada redução na, concentração do carboidrato no material estudado, sugerindo a presença de fator extrínseco veiculado pelo LCR.

SUMMARY

Using chromatographic analysis the authors studied glucose concentration in the brain of Swiss mice inoculated with CSF of four patients with amyotrophic lateral sclerosis. They found reduction in the levels of glucose, suggesting the existence of an exogenous factor tnansfered by CSF.

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Dr. J. Maurício Godoy - Serviço de Neurologia, Hospital Universitário Pedro Ernesto - Av. 28 de Setembro 87/2º andar - 20551 Rio de Janeiro RJ - Brasil.

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