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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487

Arq Bras Endocrinol Metab vol.55 no.9 São Paulo Dec. 2011 



Reply to: Insulin resistance and chronic hepatitis C in non-diabetic patients


Resposta para: Resistência à insulina e hepatite crônica em pacientes não diabéticos



Aecio Flavio Meirelles Souza; Fábio Heleno Lima Pace

Faculdade de Medicina da Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brazil

Correspondence to



We appreciate the interest of Dr. Wiwanitkit in our article recently published in Journal of the Brazilian Society of Endocrinology and Metabology. According to the study results, chronic hepatitis C patients with insulin resistance (HOMA IR> 2.5) had more advanced HCV - related liver fibrosis (1). One of the issues considered by Dr. Wiwanitkit is that our results may have been influenced by the other liver diseases. However, as described in the methods section, previous antiviral treatment, co-infection with HBV or HIV, chronic renal disease, DM2, decompensated liver cirrhosis, hepatocellular carcinoma, and alcohol intake above 20 g ethanol/d were exclusion criteria. The second question issue raised by him, is that although theon the fact that it was an observational study, data were submitted to statistical analysis (univariate analysis) and results were considered statistically significant when p < 0.05. Therefore, we found possible to conclude that there was an association between IR and HCV-induced liver fibrosis. We did not analyze in our study whether insulin resistance was independently associated with HCV-induced liver fibrosis.

Disclosure: no potential conflict of interest relevant to this article was reported.



1. Souza AF, Pace FH, Chebli JM, Ferreira LE. Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? Arq Bras Endocrinol Metab. 2011;55(6):412-8.         [ Links ]



Correspondence to:
Aecio Flavio Meirelles Souza
Av. Barão de Rio Branco, 2679/605
36010-012 - Juiz de Fora, MG, Brasil

Received on Nov/7/2011
Accepted on Nov/17/2011

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