Infiltración meningea por leucemia a celulas plasmáticas y por linfoma no Hodgkin: estudio citomorfologico en el liquido cefalo-raquideo

Tabares Olives, Arnaldo

doi:10.1590/S0004-282X1982000200002

Resúmenes

Son presentadas las características citomorfológicas anormales encontradas en el LCR de dos pacientes, uno de ellos sufriendo de leucemia aguda a células plasmáticas y otro de linfoma mixto no Hodgkin. Se enfatiza la importancia del estudio del LCR en estas patologias.

Cytomorphological findings in the cerebrospinal fluid (CSF) of two patiens suffering plasma cell leukemia and non Hodgkin's mixed cell lymphoma are reported. In the first were found inmature plasma cells, polynucleate giant cells with giant nucleoli and atypical mitoses. In the second one polynucleate giant cells with hypercromatic and polyfissured nuclei and atypical mitoses are prominent. It is emphasized the importance of the early cytomorphological CSF study in patients with myelo or lymphoproliferatíve diseases.

Infiltración meningea por leucemia a celulas plasmáticas y por linfoma no Hodgkin: estudio citomorfologico en el liquido cefalo-raquideo

Meningeal infiltration by plasma cell leukemia and non Hodgkin's lymphoma: cytomorphological study in the cerebrospinal fluid

Arnaldo Tabares Olives

Auxiliar del Servicio de Neurologia y Neurocirurgia (Jefe de Servicio, Dr. Roger Perret-Gentil Tamayo), Hospital Central de las Fuerzas Armadas, Caracas, Venezuela

RESUMEN

Son presentadas las características citomorfológicas anormales encontradas en el LCR de dos pacientes, uno de ellos sufriendo de leucemia aguda a células plasmáticas y otro de linfoma mixto no Hodgkin. Se enfatiza la importancia del estudio del LCR en estas patologias.

SUMMARY

Cytomorphological findings in the cerebrospinal fluid (CSF) of two patiens suffering plasma cell leukemia and non Hodgkin's mixed cell lymphoma are reported. In the first were found inmature plasma cells, polynucleate giant cells with giant nucleoli and atypical mitoses. In the second one polynucleate giant cells with hypercromatic and polyfissured nuclei and atypical mitoses are prominent. It is emphasized the importance of the early cytomorphological CSF study in patients with myelo or lymphoproliferatíve diseases.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Direction del autor: Tte. (A) F.A.C. Dr. Arnaldo Tabares O. - Servicio de Neurocirurgia. Hospital Central de Ias Fuerzas Armadas - Barrio Unión - San Martin - Caracas, Venezuela.

1. BILLINGHAM, M. E. RAWLINSON. D. G.; BERRY, P. F. & KEMPSON, R. L. - The çytodiagnosis of malignant lymphoma and Hodgkin's disease in cerebrospinal, pleural and ascitic fluid. Acta Cytol. Chicago 19:547, 1975.
2. BUNN, P. A. Jr.; SCHEIN, P. S.; BANKS, P. M. & DE VITA, V. T. Jr. - Central nervous system complications in patients with difuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood 47:3,1976.
3. DAWSON, D. M.; ROSENTHAL, D. S. & MOLONEY, W. C. - Neurological complications of the acute leukemia in adults: changing rate. Ann. int. Med. 79:541, 1973.
4. DYKEN, P. R. - Cerebrospinal fluid cytology: practical usefulness. Neurology (Minneapolis) 25:210, 1975.
5. GLASSER, L.; PAINE, C. & CORRIGAN, J. J. Jr. - The in vivo development of plasma cell: a morphologic study of human cerebrospinal fluid. Neurology (Minneapolis) 27:448, 1977.
6. GRIFFIN, J. W.; THOMPSON, R. W.; MITCHINSON, M. J.; KIEVIET, J. C. & WELLAND, F. H. - Lymphomatous leptomeningitis. Amer. J. M. 51:200, 1971.
7. McMILLAN, J. A. - Meningitis due to carcinomatosis. British Med. J. 5.290:1.452, 1962.
8. MOORE, E. W.; THOMAS, L. B.; SHAW, R. K. & FREIREICH, E. J. - The central nervous system in acute leukemia. Arch. int. Med. 105:451, 1960.
9. NIERI, R. L.; BURGET, E. O. & GROOVER, R. V. - Central nervous system complications of leukemia: a review. Mayo Clin. Proc. 43:70, 1968.
10. OLSON, M. E.; CHERNIK, N. L. & POSNER, J. B. - Infiltration of the leptomeninges by systemic cancer. Arch. Neurol. (Chicago) 30:122, 1974.
11. PEDREIRA-ANDRADE, J. D.; GARCIA JIMENEZ, J. R. M.; GUARDIA, J. ORTIZ; REY, C; BONET, A.; GARNACHO, A.; & MARTINEZ VAZQUEZ, J. - Leptomeningitis linfomatosa. Sangre (Barcelona) 19:177,1974.
12. POLLIACK, A.; RACHMILEWITZ, D. & ZLOTNICK, A. - Plasma cell leukemia. Arch. int. Med. 134:131, 1974.
13. PRUZANSKI, W.; PLATTS, M. E. & OGRYZLO, M. A. - Leukemic form of inmunocytic dyscrasia: plasma cell leukemia. Am. J. Med. 47:60, 1969.
14. SHAW, M. T.; TWELE, T. W. & NORDQUIST, R. E. - Plasma cell leukemia: detailed studies and response to therapy. Cancer 33:619, 1974.
15. SPARLING, H. J. Jr.; ADAMS, R. D. & PARKER, F. Jr. - Envolvement of the nervous system by malignant lymphoma. Medicine (Baltimore) 26 : 285, 1947.
16. SPINA-FRANÇA, A. - Câmaras de sedimentação no estudo citológico do líquido cefalorraqueano. Arq. Neuro-Psiquiat. (São Paulo) 28:84, 1970.
17. WERNECK, L. C; HATSBACH, Z.; MORA, A. H. & NOVAK, E. M. - Meningite por linfoma primitivo do sistema nervoso central. Arq. Neuro-Psiquiat. (São Paulo) 35:366, 1977.
18. WOLK, R. W.; MASSE, S. R.; CONKLIN, R. & FREIREICH, E. J. - The incidence of central nervous system leukemia in adults with acute leukemia. Cancer 33:863, 1974.
19. WOODRUFF, R. K.; MALPAS, J. S.; PAXTON, A. M. & LISTER, T. A. - Plasma cell leukemia: a report on 15 patients. Blood 52:839, 1978.

Fechas de Publicación

Publicación en esta colección
20 Ago 2012
Fecha del número
Jun 1982

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BILLINGHAM, M. E. RAWLINSON. D. G.; BERRY, P. F. & KEMPSON, R. L. - The çytodiagnosis of malignant lymphoma and Hodgkin's disease in cerebrospinal, pleural and ascitic fluid. Acta Cytol. Chicago 19:547, 1975.

[2] 2. BUNN, P. A. Jr.; SCHEIN, P. S.; BANKS, P. M. & DE VITA, V. T. Jr. - Central nervous system complications in patients with difuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood 47:3,1976.

[3] 3. DAWSON, D. M.; ROSENTHAL, D. S. & MOLONEY, W. C. - Neurological complications of the acute leukemia in adults: changing rate. Ann. int. Med. 79:541, 1973.

[4] 4. DYKEN, P. R. - Cerebrospinal fluid cytology: practical usefulness. Neurology (Minneapolis) 25:210, 1975.

[5] 5. GLASSER, L.; PAINE, C. & CORRIGAN, J. J. Jr. - The in vivo development of plasma cell: a morphologic study of human cerebrospinal fluid. Neurology (Minneapolis) 27:448, 1977.

[6] 6. GRIFFIN, J. W.; THOMPSON, R. W.; MITCHINSON, M. J.; KIEVIET, J. C. & WELLAND, F. H. - Lymphomatous leptomeningitis. Amer. J. M. 51:200, 1971.

[7] 7. McMILLAN, J. A. - Meningitis due to carcinomatosis. British Med. J. 5.290:1.452, 1962.

[8] 8. MOORE, E. W.; THOMAS, L. B.; SHAW, R. K. & FREIREICH, E. J. - The central nervous system in acute leukemia. Arch. int. Med. 105:451, 1960.

[9] 9. NIERI, R. L.; BURGET, E. O. & GROOVER, R. V. - Central nervous system complications of leukemia: a review. Mayo Clin. Proc. 43:70, 1968.

[10] 10. OLSON, M. E.; CHERNIK, N. L. & POSNER, J. B. - Infiltration of the leptomeninges by systemic cancer. Arch. Neurol. (Chicago) 30:122, 1974.

[11] 11. PEDREIRA-ANDRADE, J. D.; GARCIA JIMENEZ, J. R. M.; GUARDIA, J. ORTIZ; REY, C; BONET, A.; GARNACHO, A.; & MARTINEZ VAZQUEZ, J. - Leptomeningitis linfomatosa. Sangre (Barcelona) 19:177,1974.

[12] 12. POLLIACK, A.; RACHMILEWITZ, D. & ZLOTNICK, A. - Plasma cell leukemia. Arch. int. Med. 134:131, 1974.

[13] 13. PRUZANSKI, W.; PLATTS, M. E. & OGRYZLO, M. A. - Leukemic form of inmunocytic dyscrasia: plasma cell leukemia. Am. J. Med. 47:60, 1969.

[14] 14. SHAW, M. T.; TWELE, T. W. & NORDQUIST, R. E. - Plasma cell leukemia: detailed studies and response to therapy. Cancer 33:619, 1974.

[15] 15. SPARLING, H. J. Jr.; ADAMS, R. D. & PARKER, F. Jr. - Envolvement of the nervous system by malignant lymphoma. Medicine (Baltimore) 26 : 285, 1947.

[16] 16. SPINA-FRANÇA, A. - Câmaras de sedimentação no estudo citológico do líquido cefalorraqueano. Arq. Neuro-Psiquiat. (São Paulo) 28:84, 1970.

[17] 17. WERNECK, L. C; HATSBACH, Z.; MORA, A. H. & NOVAK, E. M. - Meningite por linfoma primitivo do sistema nervoso central. Arq. Neuro-Psiquiat. (São Paulo) 35:366, 1977.

[18] 18. WOLK, R. W.; MASSE, S. R.; CONKLIN, R. & FREIREICH, E. J. - The incidence of central nervous system leukemia in adults with acute leukemia. Cancer 33:863, 1974.

[19] 19. WOODRUFF, R. K.; MALPAS, J. S.; PAXTON, A. M. & LISTER, T. A. - Plasma cell leukemia: a report on 15 patients. Blood 52:839, 1978.

Brasil

Brasil

Infiltración meningea por leucemia a celulas plasmáticas y por linfoma no Hodgkin: estudio citomorfologico en el liquido cefalo-raquideo

Meningeal infiltration by plasma cell leukemia and non Hodgkin's lymphoma: cytomorphological study in the cerebrospinal fluid

Resúmenes

Fechas de Publicación