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Mortality associated with cysticercosis in a historical cohort from Britain

Mortalidade associada à cisticercose em uma coorte histórica da Grã-Bretanha

ABSTRACT

Background:

The burden of premature mortality associated with human cysticercosis is largely ignored mainly due to poor record-keeping in Taenia solium endemic regions.

Objective:

To document mortality and survival characteristics of an historical cohort with cysticercosis.

Methods:

The years of onset of symptoms and death untill 1957 were extracted from published reports of a British military cohort (n=450) examined in London in the early twentieth century. Data were entered into a Kaplan Meier survival analysis with the presence (or absence) of clinical manifestations as independent variables, which were then fitted into a Cox proportional hazards model to determine their significance.

Results:

Cysticercosis was responsible for 24 (52.2%) of 46 deaths in the first 15 years of follow-up in comparison to 7 (19.4%) of 36 deaths in the 20-40 years of follow-up period. In the univariate and Cox analyses, intracranial hypertension (hazard ratio [HR]: 8.26; CI: 4.71, 14.49), ocular cysticercosis (HR: 6.60; CI: 3.04, 14.33), and mental disorder (HR: 3.98; CI: 2.22, 7.13) but not epilepsy (HR: 0.66; CI: 0.20, 2.18) were associated with mortality. Over half of all deaths in the first 15 years of follow-up were attributed to cysticercosis.

Conclusions:

Several deaths occurred early after acquiring cysticercotic infection. Intracranial hypertension, ocular cysticercosis, and mental disorder but not epilepsy were predictors of mortality in this cohort.

Keywords:
Taenia solium; Epilepsy; Intracranial Hypertension; Survival; Mortality

RESUMO

Antecedentes:

O fardo da mortalidade prematura associada à cisticercose humana é amplamente ignorado, principalmente devido à má manutenção de registros nas regiões endêmicas de Taenia solium.

Objetivo:

Documentar as características de mortalidade e sobrevivência de uma coorte histórica com cisticercose.

Métodos:

Os anos de início dos sintomas e morte até 1957 foram extraídos de relatórios publicados de uma coorte militar britânica (n = 450) examinada em Londres no início do século XX. Os dados foram inseridos em uma análise de sobrevida de Kaplan Meier com a presença (ou ausência) de manifestações clínicas como variáveis ​​independentes, que foram então ajustadas em um modelo de risco proporcional de Cox para determinar sua significância.

Resultados:

A cisticercose foi responsável por 24 (52,2%) de 46 óbitos nos primeiros 15 anos de seguimento em comparação com 7 (19,4%) de 36 óbitos nos 20-40 anos de seguimento. Nas análises univariadas e de Cox, hipertensão intracraniana (razão de risco [HR]: 8,26; IC: 4,71, 14,49), cisticercose ocular (HR: 6,60; IC: 3,04, 14,33) e transtorno mental (HR: 3,98; IC: 2,22 , 7,13), mas não epilepsia (HR: 0,66; IC: 0,20, 2,18) foram associados com mortalidade. Mais da metade de todas as mortes nos primeiros 15 anos de acompanhamento foram atribuídas à cisticercose.

Conclusões:

Várias mortes ocorreram logo após a aquisição da infecção cisticercótica. Hipertensão intracraniana, cisticercose ocular e transtorno mental, mas não epilepsia, foram preditores de mortalidade nesta coorte.

Palavras-chave:
Taenia solium; Epilepsia; Hipertensão Intracraniana; Sobrevida; Mortalidade

INTRODUCTION

Cysticercosis, denoting human infestation with the larval stage of the pork tapeworm Taenia solium, is responsible for serious neurological morbidity in many parts of the world11. Garcia HH, Del Brutto OH, Cysticercosis Working Group in Peru. Neurocysticercosis: updated concepts about an old disease. Lancet Neurol. 2005 Oct;4(10):653-61.,22. Carpio A, Fleury A, Romo ML, Abraham R. Neurocysticercosis: the good, the bad, and the missing. Expert Rev Neurother. 2018 Apr;18(4):289-301. https://doi.org/10.1080/14737175.2018.1451328
https://doi.org/10.1080/14737175.2018.14...
. Neurological involvement, i.e., neurocysticercosis is often characterized by seizures, intracranial hypertension, dementia, and focal neurological deficits. Considering the severe manifestations, it is unsurprising that the disorder is associated with increased premature mortality. A recent systematic analysis of cysticercosis deaths in the United States (US) between 1990 and 2002 found that the mean age at death in people with cysticercosis was 41 years33. Sorvillo FJ, De Giorgio C, Waterman SH. Deaths from cysticercosis in the United States. Emerg Infect Dis. 2007 Feb;13(2):230-5. https://doi.org/10.3201/eid1302.060527
https://doi.org/10.3201/eid1302.060527...
. However, there is little information on mortality associated with cysticercosis outside the US, mainly due to ineffective public health systems and lack of surveillance systems for life events33. Sorvillo FJ, De Giorgio C, Waterman SH. Deaths from cysticercosis in the United States. Emerg Infect Dis. 2007 Feb;13(2):230-5. https://doi.org/10.3201/eid1302.060527
https://doi.org/10.3201/eid1302.060527...
-66. Santo AH. Cysticercosis-related mortality in the state of São Paulo, Brazil, 1985-2004: a study using multiple causes of death. Cad Saúde Pública. 2007 Dec;23(12):2917-27. https://doi.org/10.1590/S0102-311X2007001200013
https://doi.org/10.1590/S0102-311X200700...
.

A large cohort of people with cysticercosis was systematically followed-up in Britain in the early twentieth century77. MacArthur WP. Cysticercosis as a cause of epilepsy in man. Trans Roy Soc Trop Med Hyg. 1933;27:525-8.-1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . India was a British colony before it became independent in 1947, and British military personnel were frequently deployed in India before 1947. They and their families remained in India for varying periods of time, usually up to three years. Cysticercosis was present in Britain until it was eradicated, with only few reports in the eighteenth century. Hence, it is safe to assume that British military personnel acquired cysticercosis while serving in India, where it remained mostly undiagnosed. Upon their return, they were examined at the Queen Alexandra Military Hospital in London for neurological symptoms including seizures. The hospital specialized in the treatment of non-combat related disorders. After diagnosis, the returnees were retired from military service but were maintained on follow-up until 1957. The cohort was thus comprised of people diagnosed between 1921 and 1957.

We performed a secondary analysis of data contained in various published reports on this cohort from the 1920s to 1961. Here we report survival rates and their relationship with various clinical presentations in this historical cohort.

METHODS

Cohort composition

This cohort consisted mainly of members of the British army and their families who had previously served in India and had contracted cysticercosis there. They were identified between 1921 and 1957 and were followed-up by army medics at Queen Alexandra Military Hospital, London1313. Singh G, Sander JW. Historical perspective: the British contribution to the understanding of neurocysticercosis. J Hist Neurosci. 2019 Jul-Sep;28(3):332-44. https://doi.org/10.1080/0964704X.2018.1564523
https://doi.org/10.1080/0964704X.2018.15...
,1414. Del Brutto OH, García HH. Taenia solium cysticercosis -- The lessons of history. J Neurol Sci. 2015 Dec 15;359(1-2):392-5. https://doi.org/10.1016/j.jns.2015.08.011
https://doi.org/10.1016/j.jns.2015.08.01...
. The earliest report of five cases dates back to 193077. MacArthur WP. Cysticercosis as a cause of epilepsy in man. Trans Roy Soc Trop Med Hyg. 1933;27:525-8. but the number increased to 71 cases in 193499. Dixon HBF, Smithers DW. Epilepsy in cysticercosis (Taenia solium): a study of seventy-one cases. Q J Med. 1934 Oct 1;3(4):603-16. https://doi.org/10.1093/qjmed/3.4.603
https://doi.org/10.1093/qjmed/3.4.603...
, 284 in 1944,1111. Dixon HBF, Hargreaves WH. Cysticercosis (Taenia solium) a further ten years' clinical study, covering 284 cases. Q J Med. 1944 Oct 1;13(4):107-22. https://doi.org/10.1093/oxfordjournals.qjmed.a066444
https://doi.org/10.1093/oxfordjournals.q...
and to 450 in 19571212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . Deployment of military personnel to India ceased in 1947 and the last case was diagnosed in 1949. In response to the initial reports, the Army supported continued scrutiny of the cases and longitudinal data were systematically collected. The final report was published in 1961 and contained data up to August 19571212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. .

Clinical presentations

The final report contained the findings of the autopsy of 55 of the subjects who died before August 19571212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . The report included the forms of presentation coded as epilepsy, focal neurological deficit, intracranial hypertension, mental disorder, ocular cysticercosis, subcutaneous involvement, lingual cysticercosis, muscular disorder, and acute febrile illness, as well as the year of symptom-onset and death. The report also categorized the causes of death into those due to cysticercosis and those due to other causes. Death was attributed to cysticercosis if the immediate or underlying cause was reported as related to epilepsy (status epilepticus, drowning, phenobarbital overdose, and suicide), intracranial hypertension, or cysticercotic meningitis. We used the reported year of symptom onset and year of death in those who died1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . In those who remained asymptomatic, the year of exposure was assumed from the mid-point of their deployment in India. The original reports also provided data on asymptomatic cases, which were also included in examination of their association with survival77. MacArthur WP. Cysticercosis as a cause of epilepsy in man. Trans Roy Soc Trop Med Hyg. 1933;27:525-8.-1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. .

Statistical analysis

Data were entered into a Kaplan Meier survival analysis, and subjects were considered at risk of dying from the year of symptom onset. They exited at either death or censoring, whichever occurred earlier. Censoring was at the time of the last follow-up (August 1957). The association between the presence or absence of each category of clinical manifestations was examined in univariate analyses. The presence or absence of manifestations was then fitted as a covariate in a Cox proportional hazard model to estimate exponential individual coefficients and hazard ratios. The coefficients represent the hazard ratio for a unit change in the covariate. Stata version 15.1 (StataCorp, TX, USA) was used for analysis.

RESULTS

The final report provided details of 450 cases up to August 19571212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . The diagnosis of cysticercosis in the cohort was established by biopsy of subcutaneous nodules in 108 (24%), by radiology of the limbs and skull in 313 (70%), by autopsy or surgery in 22 (5%), and by ocular cysticercosis in 21212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. .

Total follow-up accounted for 9713 person-years starting in 1891, the year of symptom-onset in the first subject. Three-hundred-fifty-six (79%) individuals were alive in 1957. Survival at one year was 99% (95% Confidence Intervals [CI]: 98%, 100%), at five years, 95% (CI: 93%, 97%) and at 10 years, 92% (CI: 89%, 94%). Of the 94 (21%) deaths, 47 (50%) were attributed to cysticercosis. When only deaths attributed to cysticercosis were considered, the cause-specific survival at one year was 99% (CI: 98, 100), at five years 96% (CI: 93%, 97%) and at 10 years, 93% (CI: 91%, 95%). The median overall survival was 23 years (range: 1-59 years). Overall mortality rate was 9.7 (CI: 7.6, 11.5) per 1000 person-years. Considering cysticercosis-related deaths only, the estimated mortality rate was 4.6 (CI: 3.5, 6.2) per 1000 person-years.

Seven (47.6%) of 18 deaths in the first 5 years of follow-up, 9 (56.3%) of 16 deaths in the next five years, and 8 (66.7%) of 12 deaths in the 11-15 years follow-up period were attributed to cysticercosis. In comparison, the proportional mortality attributed to cysticercosis was comparatively lower from 20 years onwards (21-25 years: 2 [20%] out of 10; 26-30 years: 4 [30.8%] out of 13; 31-35 years: 1 (10%) out of 10, and 36-40 years: none out of 3). Overall, 27 (81.8%) of the cysticercosis-related deaths and 49 (59.8%) of 91 all-cause deaths occurred in the first 15 years of follow-up.

Survivor function and clinical presentations

The clinical features of the cohort are shown in Table 1. Epilepsy was the commonest presentation, with 413 (91.8%) affected people. Subcutaneous nodules were detected in 243 (54%) subjects. In all, only 15 (3.3%) subjects remained asymptomatic throughout the observation period.

Table 1.
Clinical characteristics of the cohort.

The characteristics of survivors (Table 2) were similar in people with and without (asymptomatic subjects with cysticercosis) symptoms (P=0.42), those with and without epilepsy (P=0.54) (Figure 1), those with and without focal neurological deficits (P=0.27), and those with and without subcutaneous infestation (P=0.45). Conversely, survival was lower in those with intracranial hypertension (median survival: 6 years) (P=0.00001) (Figure 2), mental disorder (median survival: 13 years) (P=0.00001), ocular cysticercosis (median survival: 9 years) (P=0.00001), and those with a febrile illness (P=0.004), each compared with those without the same presentation. Mortality rates associated with cysticercosis were generally lower in subjects with epilepsy (5/1000 person-years; CI: 3-6/1000 person-years) and subcutaneous cysticercosis (5/1000 person-years; CI: 4-8/1000 person-years), but it was higher in subjects with lingual involvement (14/1000 person-years; CI: 4-51/1000 person-years), mental disorder (20/1000 person-years; CI: 12-34/1000 person-years), febrile illness (31/1000 person-years; CI: 8-125/1000 person-years), ocular cysticercosis (34/1000 person-years; CI: 14-53/1000 person-years), and intracranial hypertension (47/1000 person-years; CI: 29-76/1000 person-years).

Table 2.
Overall and cause-specific mortality associated with different clinical manifestations.

Figure 1.
Kaplan Meier survival curves in individuals with and without epilepsy in the British military cohort.

Figure 2.
Kaplan Meier survival curves in individuals with and without intracranial hypertension in the British military cohort.

When clinical variables were fitted in a Cox proportional hazards model to test overall survival, the model was significant (P=0.00001) with intracranial hypertension (hazard ratio [HR]: 8.26; CI: 4.71, 14.49), ocular cysticercosis (HR: 6.60; CI: 3.04, 14.33), and mental disorder (HR: 3.98; CI: 2.22, 7.13) being significant predictors of survival (Table 3). The three clinical variables remained significant predictors of survival in the model to test cause (cysticercosis)-specific survival (overall P of the model = 0.00001).

Table 3.
Hazard ratios for overall and cause-specific survival outcomes associated with different clinical manifestations.

DISCUSSION

Evidence derived from this cohort has had a profound influence on the current understanding of cysticercosis1313. Singh G, Sander JW. Historical perspective: the British contribution to the understanding of neurocysticercosis. J Hist Neurosci. 2019 Jul-Sep;28(3):332-44. https://doi.org/10.1080/0964704X.2018.1564523
https://doi.org/10.1080/0964704X.2018.15...
,1414. Del Brutto OH, García HH. Taenia solium cysticercosis -- The lessons of history. J Neurol Sci. 2015 Dec 15;359(1-2):392-5. https://doi.org/10.1016/j.jns.2015.08.011
https://doi.org/10.1016/j.jns.2015.08.01...
. Our analysis of mortality and survival provides further insights, as cysticercosis-related mortality is a major public health issue largely neglected partly due to the constraints of poor record-keeping in endemic areas33. Sorvillo FJ, De Giorgio C, Waterman SH. Deaths from cysticercosis in the United States. Emerg Infect Dis. 2007 Feb;13(2):230-5. https://doi.org/10.3201/eid1302.060527
https://doi.org/10.3201/eid1302.060527...
-66. Santo AH. Cysticercosis-related mortality in the state of São Paulo, Brazil, 1985-2004: a study using multiple causes of death. Cad Saúde Pública. 2007 Dec;23(12):2917-27. https://doi.org/10.1590/S0102-311X2007001200013
https://doi.org/10.1590/S0102-311X200700...
. Despite the limitation of the absence of data on the age characteristics of the cohort, our findings suggest that cysticercosis substantially contributed to premature mortality. This is because cysticercosis usually occurs in young people and most deaths attributed to cysticercosis occurred in the first 15 years of exposure in this historical cohort1515. O'Keefe KA. Cysticercosis in the United States: A nationwide hospitalization study assessing burden of disease, fatality risk factors and economic impact of infection [dissertation]. [Los Angeles (CA)]: University of California; 2013. 76p.-2020. Stepien L. Cerebral cysticercosis in Poland. Clinical symptoms and operative results in 132 cases. J Neurosurg. 1962 Jun;19:505-13. https://doi.org/10.3171/jns.1962.19.6.0505
https://doi.org/10.3171/jns.1962.19.6.05...
. Only very recently has the premature mortality associated with infestation been confirmed by an analysis of cysticercosis-related deaths in the USA, which estimated a mean age at death of 40.5 years33. Sorvillo FJ, De Giorgio C, Waterman SH. Deaths from cysticercosis in the United States. Emerg Infect Dis. 2007 Feb;13(2):230-5. https://doi.org/10.3201/eid1302.060527
https://doi.org/10.3201/eid1302.060527...
.

How does the mortality estimate of 4.6/1000 person-years in our cohort compare with current data? A Brazilian report estimated a crude mortality rate of 0.88-2.51/million people in 1995-200466. Santo AH. Cysticercosis-related mortality in the state of São Paulo, Brazil, 1985-2004: a study using multiple causes of death. Cad Saúde Pública. 2007 Dec;23(12):2917-27. https://doi.org/10.1590/S0102-311X2007001200013
https://doi.org/10.1590/S0102-311X200700...
. In comparison, analysis of the nationwide inpatient sample from the USA produced an estimate of 0.1 deaths/million population1515. O'Keefe KA. Cysticercosis in the United States: A nationwide hospitalization study assessing burden of disease, fatality risk factors and economic impact of infection [dissertation]. [Los Angeles (CA)]: University of California; 2013. 76p.. When death certificates from the National Centre for Health Statistics were the source, mortality estimates for the period 1990-2002 amounted to 0.06/million population33. Sorvillo FJ, De Giorgio C, Waterman SH. Deaths from cysticercosis in the United States. Emerg Infect Dis. 2007 Feb;13(2):230-5. https://doi.org/10.3201/eid1302.060527
https://doi.org/10.3201/eid1302.060527...
.

Careful documentation of presentations and year of symptom-onset and death in the whole cohort provided an opportunity to assess the relationship between various clinical presentations and mortality. In the Cox model, intracranial hypertension, mental disorder, and ocular cysticercosis, but not epilepsy, were associated with reduced survival (Table 3). Intracranial hypertension is a severe manifestation of cysticercosis and might occur as a result of non-obstructive hydrocephalus associated with basal sub-arachnoid cysticercosis, obstructive hydrocephalus due to intraventricular cysticercosis, giant solitary cysticerci, or multiple parenchymal cysticerci with massive cerebral edema1616. Sotelo J, Marin C. Hydrocephalus secondary to cysticercotic arachnoiditis. A long-term follow-up review of 92 cases. J Neurosurg. 1987 May;66(5):686-9. https://doi.org/10.3171/jns.1987.66.5.0686
https://doi.org/10.3171/jns.1987.66.5.06...
-2020. Stepien L. Cerebral cysticercosis in Poland. Clinical symptoms and operative results in 132 cases. J Neurosurg. 1962 Jun;19:505-13. https://doi.org/10.3171/jns.1962.19.6.0505
https://doi.org/10.3171/jns.1962.19.6.05...
. Two conditions, cysticercotic encephalitis and disseminated cysticercosis, characterized by massive brain infection and intracranial hypertension1818. Wadia N, Desai S, Bhatt M. Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel. Brain. 1988 Jun 1;111(3):597-614. https://doi.org/10.1093/brain/111.3.597
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,1919. Rangel R, Torres B, Del Brutto O, Sotelo J. Cysticercotic encephalitis: a severe form in young females. Am J Trop Med Hyg. 1987 Mar;36(2):387-92. https://doi.org/10.4269/ajtmh.1987.36.387
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are still associated with high case fatality rates. Obstructive hydrocephalus could have contributed to death in seven subjects who underwent neurosurgical treatment, as five of them died soon after probably due to the procedure1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . A Polish report from the 1960s suggested that nearly two thirds of those with hydrocephalus resulting from basal arachnoidal cysticercosis died from the disease2020. Stepien L. Cerebral cysticercosis in Poland. Clinical symptoms and operative results in 132 cases. J Neurosurg. 1962 Jun;19:505-13. https://doi.org/10.3171/jns.1962.19.6.0505
https://doi.org/10.3171/jns.1962.19.6.05...
. The only available surgical treatment for obstructive hydrocephalus at the time was ventriculostomy. Shunt procedures were implemented several decades later and led to a decline in mortality associated with hydrocephalus2121. Colli BO, Martelli N, Assirati Júnior JA, Machado HR, Salvarani CP, Sassoli VP, et al. Cysticercosis of the central nervous system. I. surgical treatment of cerebral cysticercosis: a 23 years experience in the hospital das clinicas of Ribeirão Preto Medical School. Arq Neuropsiquiatr. 1994 Jun;52(2):166-86. https://doi.org/10.1590/s0004-282x1994000200006
https://doi.org/10.1590/s0004-282x199400...
. Likewise, the application of medical treatment in the form of repeated courses of albendazole signaled a major breakthrough in the management of subarachnoid cysticercosis with intracranial hypertension2222. Proaño JV, Madrazo I, Avelar F, López Félix B, Díaz G, Grijalva I. Medical treatment for neurocysticercosis characterized by giant subarachnoid cysts. N Engl J Med. 2001 Sep 20;345(12):879-85. https://doi.org/10.1056/NEJMoa010212
https://doi.org/10.1056/NEJMoa010212...
. Besides intracranial hypertension, both mental disorders and ocular cysticercosis were associated with reduced survival. Mental disorders, described in many early reports, are also associated with heavy cerebral infection1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. ,1818. Wadia N, Desai S, Bhatt M. Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel. Brain. 1988 Jun 1;111(3):597-614. https://doi.org/10.1093/brain/111.3.597
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,2323. Pupo PP, Cardoso W, Reis JB, et al. Sobre a cisticercose encefálica. Estudo clínico, anatomopatológico, radiológico e do liquido cefalo-raqueano. Archivos da Assistência aos Psicopatas de São Paulo 1946;10-11:3-123.,2424. Forlenza OV, Vieira Filho AH, Nobrega JP, Machado LR, Barros NG, Camargo CH, et al. Psychiatric manifestations of neurocysticercosis: a study of 38 patients from a neurology clinic in Brazil. J Neurol Neurosurg Psychiatry. 1997 Jun 1;62(6):612-6. https://doi.org/10.1136/jnnp.62.6.612
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. Presumably, many subjects in the cohort had heavy infection loads, which is supported by the fact that more than half of the subjects had subcutaneous nodules, a surrogate for a heavy cyst burden1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. .

The lack of an association of mortality with epilepsy is difficult to explain, especially in view of the well-established association between epilepsy and premature mortality (Tables 2 and 3; Figure 1) 2525. Levira F, Thurman DJ, Sander JW, Hauser WA, Hesdorffer DC, Masanja H, et al. Premature mortality of epilepsy in low- and middle-income countries: a systematic review from the Mortality Task Force of the International League Against Epilepsy. Epilepsia. 2017 Jan;58(1):6-16. https://doi.org/10.1111/epi.13603
https://doi.org/10.1111/epi.13603...
. An original report analyzed the causes of death in a representative sample and found status epilepticus as the immediate cause of death in 18 cases (43%)1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . A possible explanation arises from the small proportion of patients without epilepsy (n=37 of 450; 8%; Appendix, Table 1), which could inadvertently inflate the number of deaths in the subgroup without epilepsy in a cohort with severe cysticercosis. Alternatively, the occurrence of seizures might have led to earlier diagnosis (and thus better prognosis) by physicians familiar with epilepsy as a manifestation of cysticercosis77. MacArthur WP. Cysticercosis as a cause of epilepsy in man. Trans Roy Soc Trop Med Hyg. 1933;27:525-8.-99. Dixon HBF, Smithers DW. Epilepsy in cysticercosis (Taenia solium): a study of seventy-one cases. Q J Med. 1934 Oct 1;3(4):603-16. https://doi.org/10.1093/qjmed/3.4.603
https://doi.org/10.1093/qjmed/3.4.603...
. A parallel can be drawn from studies of cerebral glioma, in which the occurrence of seizures is an independent predictor of improved survival2626. Fan X, Li Y, Shan X, You G , Wu Z, Li Z, et al. Seizures at presentation are correlated with better survival outcomes in adult diffuse glioma: a systematic review and meta-analysis. Seizure. 2018 Jul 1;59:P16-23. https://doi.org/10.1016/j.seizure.2018.04.018
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.

Our findings must be interpreted in light of the prevailing standards of care at the time. One discernible difference between the historical and modern series relates to the available diagnostic tools for neurocysticercosis. In this cohort, limb and skull x-rays and biopsies of subcutaneous nodules were the main diagnostic methods and were perhaps only able to diagnose the more severe infestations77. MacArthur WP. Cysticercosis as a cause of epilepsy in man. Trans Roy Soc Trop Med Hyg. 1933;27:525-8.-1212. Dixon HBF, Lipscomb FM. Cysticercosis: an analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. London (UK): H.M. Stationery Office; 1961. . Currently, neuroimaging is almost always used to establish the diagnosis of neurocysticercosis and this has led to the recognition of milder forms of infestation with solitary (or 1-2 cysts) parenchymal cysticercosis, a condition with an excellent prognosis2727. Singh G, Rajshekhar V, Murthy JM, Prabhakar S, Modi M, Khandelwal N, et al. A diagnostic and therapeutic scheme for a solitary cysticercus granuloma. Neurology. 2010 Dec 14;75(24):2236-45. https://doi.org/10.1212/WNL.0b013e31820202dc
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,2828. Del Brutto OH. Single parenchymal brain cysticercus in the acute encephalitic phase: definition of a distinct form of neurocysticercosis with a benign prognosis. J Neurol Neurosurg Psychiatry. 1995 Feb 1;58(2):247-9. https://doi.org/10.1136/jnnp.58.2.247
https://doi.org/10.1136/jnnp.58.2.247...
. Some of the medications that are the standard of care today, such as the anthelminthic agents albendazole and praziquantel, and intravenous agents used to treat status epilepticus were not available in the early twentieth century2929. Robles C, Chavarria MC. Presentactión de un caso clínio de cisticercosis cerebral tratado mèdicamente con un nuevo fàrmaco: praziquantel. Salud Publica Mex. 1979 Sep-Oct;21(5):603-18.-3333. Neligan A, Shorvon SD. The history of status epilepticus and its treatment. Epilepsia. 2009 Mar;50(3 Suppl 3):56-68. https://doi.org/10.1111/j.1528-1167.2009.02040.x
https://doi.org/10.1111/j.1528-1167.2009...
. Our study was also limited by the absence of data on the age of individual subjects, which precluded the estimation of age-adjusted mortality rates. The findings of the association between intracranial hypertension, mental disorders, and ocular cysticercosis and reduced survival are noteworthy and currently relevant. We believe that our analysis is not only of historical interest, as it also provides a useful estimate of mortality and survival in people with cysticercosis.

Acknowledgements

Data for the survival analysis performed in this study was obtained from: Dixon HBF, Lipscomb FM. Cysticercosis: An analysis and follow-up of 450 cases. Medical Research Council, Special report series, No. 299. Her Majesty’s Stationery Office, London, UK 1961. Permission to use the data was provided by the Medical Research Council, part of the UK Research and Innovation Council. Following permission, the Institutional Ethics Committee of Dayanand Medical College, Ludhiana, India approved the study plan. This work was carried out at UCLH/UCL Comprehensive Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health's NIHR Biomedical Research Centers funding scheme. JWS receives support from the Dr. Marvin Weil Epilepsy Research Fund, the Christelijke Verenigingvoor de Verpleging van Lijdersaan Epilepsie, Netherlands, and UK Epilepsy Society.

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Publication Dates

  • Publication in this collection
    25 Feb 2022
  • Date of issue
    Mar 2022

History

  • Received
    27 Feb 2021
  • Reviewed
    17 Apr 2021
  • Accepted
    13 May 2021
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