Revisão de 45 casos de tuberculose miliar em adultos - estudos clínicopatológicos

Gonçalves, Adrelirio José Rios; Suzuki, Lucia Emi; Moreira, Adilson Sarmet; Faray, Sonia Regina Carvalho; Tavares, Sonia Mana; G. Neto, Francisco Duarte; Souza, Robson José da Silva; Viana, Albanita Prado; Castro, Tercia Teles de

doi:10.1590/S0037-86821972000200001

Resumos

Os autores apresentem uma revisão de 45 casos de tuberculose viiliar em adultos, sendo que 42 foram selecionados de urn total de 4.000 necropsias. Uma correlação clínico-patológica é feita senão nitidamente evidenciado c baixo grau de suspeita clinica da doenca e a relativa freqüência desta infecção em Hospitais Gerais conseqüente à mimetização com outras patologias. Uma classificação histovatológica da condição é feita, assim como os principais órgãos atingidos são assinalados. Discussão a respeito dos mecanismos patogênicos é tentada. Finalizam com uma revisão a respeito dos problemas gerais envolvidos na tuberculose miliar.

The aa. studied 45 cases of miliary tuberculosis in adults; 42 were selected from a total of 4.900 necropsies. A clinical-pathological correlation was made showing its relative frequency in a General Hospital as well as a low incidence of clinical suspicion of this disease due to its mimmetitation with other pathological conditions. A histopathological classification was proposed by the aa. and the frequency of the organs involved was mentioned. A ternptative explanation about the pathogenic mechanism of the disease was considered. A review of the general problems involved with miliary tuberculosis is also considered.

Revisão de 45 casos de tuberculose miliar em adultos Estudos clínicopatológicos

Clinical and pathological review on 45 cases of miliary tuberculosis in adults

Adrelirio José Rios Gonçalves^I; Lucia Emi Suzuki^II; Adilson Sarmet Moreira^II; Sonia Regina Carvalho Faray^II; Sonia Mana Tavares^II; Francisco Duarte G. Neto^III; Robson José da Silva Souza^IV; Albanita Prado Viana^IV; Tercia Teles de Castro^IV

^IMédico cio Serviço de Clínica Medica do H S.E. Do Hospital Isolamento Francisco de Castro

^IIResidente do Serviço de Clinica Médica

^IIIChefe de Clinica do Serviço de Anatomia Patologiea

^IVResidentes do Serviço de Anatomia Patológica

RESUMO

Os autores apresentem uma revisão de 45 casos de tuberculose viiliar em adultos, sendo que 42 foram selecionados de urn total de 4.000 necropsias.

Uma correlação clínico-patológica é feita senão nitidamente evidenciado c baixo grau de suspeita clinica da doenca e a relativa freqüência desta infecção em Hospitais Gerais conseqüente à mimetização com outras patologias.

Uma classificação histovatológica da condição é feita, assim como os principais órgãos atingidos são assinalados.

Discussão a respeito dos mecanismos patogênicos é tentada.

Finalizam com uma revisão a respeito dos problemas gerais envolvidos na tuberculose miliar.

ABSTRACT

The aa. studied 45 cases of miliary tuberculosis in adults; 42 were selected from a total of 4.900 necropsies.

A clinical-pathological correlation was made showing its relative frequency in a General Hospital as well as a low incidence of clinical suspicion of this disease due to its mimmetitation with other pathological conditions.

A histopathological classification was proposed by the aa. and the frequency of the organs involved was mentioned.

A ternptative explanation about the pathogenic mechanism of the disease was considered. A review of the general problems involved with miliary tuberculosis is also considered.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Recebido para publicação em 28.9.11.

1. AUERBACH, O. Acute generalized miliary tuberculosis. Am. J. Path. 20: 121, 1944.
2. BAYLE, G. Recherches sur la phthisie pulmonaire. 439 pp. Liver-pool Longman & Company, 1815, p. 132.
3. BENDA, C. Uber akute miliartuberkulose. Berl. klin. Wehnschr, 1899.
4. BUHL, L. Inflammation of the lungs. Tuberculosis and consumption 161 pp. New York: G. P. Putnam's Sons. 1874 p. 107.
5. CHAPMAN, C. B. and WHORTON, C. M. Acute generalized miliary tuberculosis in adults. New Eng. J. Med. 23b: 239, 1946.
6. COOPER, W. Pancytopenia associated with disseminatel tuberculosis. Ann. Intern. Med. 50: 1497, 1959.
7. FALK, A. Tuberculous pleurisy with effusion diagnosis and results of chemotherapy. Postgraduate Medicine 38: 631, 1965.
8. FONTES MAGARÃO, M.; DAUSTER, J. e SANTIAGO, A. C. Resistência do bacilo de Koch às drogas standard e de reserva (experiência da Guanabara) . Arquivos Brasileiros de Tuberculose e Doenças do Tórax. 25: 3, 1966.
9. GLASSER. R. M.; WALKER, R J. and HERION, J. C. The significance of hematologic abnormalities in patients with tuberculosis. Arch Int. Med. 125: 691, 1970.
10. HARTWICH, A. Statistiche Mitteilungen über Miliartuberkulose. Virchows Arch. f. Path. Anat. 237: 196, 1922.
11. HUGHES. T. J.; JOHNSTONE, R. M.; SCOTT, A. C. et al: Leukemoid reactions in disseminated tuberculosis. J. Clin. Path. 12: 307, 1959.
12. KORN, R. J.; KELLOW, W. F.; HELLER, P.; CHOMET, B. and ZIMMERMANN, H. J. Hepatic involvement in extrapulmonary tuberculosis. Am. J. Med. 27: 60, 1959.
13. LAENNEC, R. A treatise on the diseases of the chest and on medical auscultation. Fourth edition 676 pp. London: Green and Longman, 1834 p. 253.
14. LORBER, J. The long-term prognosis of generalized miliary tuberculosis in children. Lancet 2: 1447, 1966.
15. MILDER, E.; OXENHORN, S.; SCHLECKER, A. et al: A case of miliary tuberculosis simulating acute blastic leukemia. J.A.M.A. 177: 116, 1961
16. O'BRIEN, J. R. Non-reactive tuberculosis. J. Clin. Path. 7; 216, 1954.
17. OLAZABAL, F. Jr Choroidal tubercles a neglected sign. J. A. M. A. 200: 374, 1967.
18. PAAR, J. A.; SCHEINMAN, M. A. and WEAVER, R. A. Disseminated non-reactive tuberculosis with basophilia, leukemoid reaction and terminal pan-cytopenia. New Eng. J. Med. 274: 335, 1966.
19. PROUDFOOT, A. T.; AKHTAR, A. J.; DOUGLAS, A. C. and HORNE, A. W. Miliary tuberculosis in adults. Brit. Med. J. 2: 273, 1969.
20. REISNER, D. Relations between extrapulmonary and pulmonary tuberculosis. Am. Rev. Tuberc. 30: 375, 1934.
21. ROBERTS, H. J. Difficult diagnosis a guide to the interpretation of obscure illness. W. B. Saunders Company, 1958.
22. ROCHA, E. P. A mortalidade por tuberculose no Estado da Guanabara. Rev. do Servico Nadonal de Tuberculose 45: 26, 1968.
23. ROPER, W. H. and WARING, J. J. Primary serofibrinous pleural effusion in military personnel. Am. Rev Tuberc. & Pulm. Dis. 71: 616, 1955.
24. TREIP, c. and MEYERS, D. Fatal tuberculosis in a General Hospital a diagnostic problem. Lancet 1: 164, 1959.
25. WEIGERT, C. Uber Venentuberkel und ihre Zeziehungen zur tuberkulösen blutinfection. Virchowes Arch, f Path. Anat. 88: 307, 1882.
26. WITHERS, K. L. Leukemoid react-ion in disseminated tuberculosis: a review of the literature with report of a case. Med. J. Aust. 1: 142, 1964.

Datas de Publicação

Publicação nesta coleção
25 Jun 2013
Data do Fascículo
Abr 1972

Histórico

Aceito
28 Set 2011
Recebido
28 Set 2011

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. AUERBACH, O. Acute generalized miliary tuberculosis. Am. J. Path. 20: 121, 1944.

[2] 2. BAYLE, G. Recherches sur la phthisie pulmonaire. 439 pp. Liver-pool Longman & Company, 1815, p. 132.

[3] 3. BENDA, C. Uber akute miliartuberkulose. Berl. klin. Wehnschr, 1899.

[4] 4. BUHL, L. Inflammation of the lungs. Tuberculosis and consumption 161 pp. New York: G. P. Putnam's Sons. 1874 p. 107.

[5] 5. CHAPMAN, C. B. and WHORTON, C. M. Acute generalized miliary tuberculosis in adults. New Eng. J. Med. 23b: 239, 1946.

[6] 6. COOPER, W. Pancytopenia associated with disseminatel tuberculosis. Ann. Intern. Med. 50: 1497, 1959.

[7] 7. FALK, A. Tuberculous pleurisy with effusion diagnosis and results of chemotherapy. Postgraduate Medicine 38: 631, 1965.

[8] 8. FONTES MAGARÃO, M.; DAUSTER, J. e SANTIAGO, A. C. Resistência do bacilo de Koch às drogas standard e de reserva (experiência da Guanabara) . Arquivos Brasileiros de Tuberculose e Doenças do Tórax. 25: 3, 1966.

[9] 9. GLASSER. R. M.; WALKER, R J. and HERION, J. C. The significance of hematologic abnormalities in patients with tuberculosis. Arch Int. Med. 125: 691, 1970.

[10] 10. HARTWICH, A. Statistiche Mitteilungen über Miliartuberkulose. Virchows Arch. f. Path. Anat. 237: 196, 1922.

[11] 11. HUGHES. T. J.; JOHNSTONE, R. M.; SCOTT, A. C. et al: Leukemoid reactions in disseminated tuberculosis. J. Clin. Path. 12: 307, 1959.

[12] 12. KORN, R. J.; KELLOW, W. F.; HELLER, P.; CHOMET, B. and ZIMMERMANN, H. J. Hepatic involvement in extrapulmonary tuberculosis. Am. J. Med. 27: 60, 1959.

[13] 13. LAENNEC, R. A treatise on the diseases of the chest and on medical auscultation. Fourth edition 676 pp. London: Green and Longman, 1834 p. 253.

[14] 14. LORBER, J. The long-term prognosis of generalized miliary tuberculosis in children. Lancet 2: 1447, 1966.

[15] 15. MILDER, E.; OXENHORN, S.; SCHLECKER, A. et al: A case of miliary tuberculosis simulating acute blastic leukemia. J.A.M.A. 177: 116, 1961

[16] 16. O'BRIEN, J. R. Non-reactive tuberculosis. J. Clin. Path. 7; 216, 1954.

[17] 17. OLAZABAL, F. Jr Choroidal tubercles a neglected sign. J. A. M. A. 200: 374, 1967.

[18] 18. PAAR, J. A.; SCHEINMAN, M. A. and WEAVER, R. A. Disseminated non-reactive tuberculosis with basophilia, leukemoid reaction and terminal pan-cytopenia. New Eng. J. Med. 274: 335, 1966.

[19] 19. PROUDFOOT, A. T.; AKHTAR, A. J.; DOUGLAS, A. C. and HORNE, A. W. Miliary tuberculosis in adults. Brit. Med. J. 2: 273, 1969.

[20] 20. REISNER, D. Relations between extrapulmonary and pulmonary tuberculosis. Am. Rev. Tuberc. 30: 375, 1934.

[21] 21. ROBERTS, H. J. Difficult diagnosis a guide to the interpretation of obscure illness. W. B. Saunders Company, 1958.

[22] 22. ROCHA, E. P. A mortalidade por tuberculose no Estado da Guanabara. Rev. do Servico Nadonal de Tuberculose 45: 26, 1968.

[23] 23. ROPER, W. H. and WARING, J. J. Primary serofibrinous pleural effusion in military personnel. Am. Rev Tuberc. & Pulm. Dis. 71: 616, 1955.

[24] 24. TREIP, c. and MEYERS, D. Fatal tuberculosis in a General Hospital a diagnostic problem. Lancet 1: 164, 1959.

[25] 25. WEIGERT, C. Uber Venentuberkel und ihre Zeziehungen zur tuberkulösen blutinfection. Virchowes Arch, f Path. Anat. 88: 307, 1882.

[26] 26. WITHERS, K. L. Leukemoid react-ion in disseminated tuberculosis: a review of the literature with report of a case. Med. J. Aust. 1: 142, 1964.

Brasil

Brasil

Revisão de 45 casos de tuberculose miliar em adultos - estudos clínicopatológicos

Clinical and pathological review on 45 cases of miliary tuberculosis in adults

Resumos

Datas de Publicação

Histórico