Oral cavity syphilides

Two epidemiologically unrelated human immunodeficiency virus (HIV)-infected patients (a 28-year-old man who engaged in sexual intercourse with men and a 20-year-old transwoman who engaged in sexual intercourse with men) presented with generalized papulosquamous rashes highly suggestive of secondary syphilis (Figure 1A and Figure 1B). Thorough clinical examinations revealed asymptomatic oral lesions. Patient 1 exhibited a rounded erythematous macule surrounded by a violaceous crescentic halo over the hard palate (Figure 1C). Patient 2 had an oval mucous patch covered by a whitish pseudomembrane on the lower labial mucosa (Figure 1D). Syphilis serologies (which previously tested negative) yielded positive results. All tegumentary and mucosal lesions regressed after appropriate penicillin treatment. Diagnoses of secondary syphilis with mucosal syphilides were made.

FIGURE 1:
Clinical images of the patients. A) A papulosquamous rash over the palms of a 28-year old man who has sex with men (Patient 1); B) A papulosquamous rash over the palms of a 20-year-old trans woman who has sex with men (Patient 2); C) A faint rounded erythematous macule surrounded by a violaceous crescentic halo over the central hard palate of Patient 1 (black circle). A few satellite erythematous pinpoint macules can be seen (black arrows); D) A small, faint, oval, aphthous-like mucous-patch lesion covered by a whitish fibrinous pseudomembrane on the lower labial mucosa of Patient 2 (white arrow). An erythematous area extending to the vestibular fold and the labial frenulum is also seen (white circle).

Oral lesions of secondary syphilis may vary in presentation and are probably underdiagnosed^1-3. They are classified into macular syphilides, papular syphilides (which are rare), and mucous patches². Macular syphilides tend to arise in the hard palate, as in patient 1^1,2. Mucous patches are considered fundamental lesions of secondary syphilis. They present as painful or asymptomatic, oval or crescentic, slightly raised or shallow erosions, or whitish plaques that may coalesce and form serpiginous lesions. The most frequently recorded sites are the soft palate, pillars, tongue, and vestibular and labial mucosa, as in patient 2. Lesions rapidly regress after treatment. Reasonable precautions, such as wearing gloves, should be taken when handling such lesions since they are reported to be the most infectious of all^1,3. Syphilis should be included as a differential diagnosis of all unexplained oral lesions³.

REFERENCES

• ¹
  Meyer I, Shklar G. The oral manifestations of acquired syphilis. A study of eighty-one cases. Oral Surg Oral Med Oral Pathol. 1967;23(1):45-57.
• ²
  Leão JC, Gueiros LA, Porter SR. Oral manifestations of syphilis. Clinics. 2006;61(2):161-6.
• ³
  Mani NJ. Secondary syphilis initially diagnosed from oral lesions. Report of three cases. Oral Surg Oral Med Oral Pathol . 1984;58(1):47-50.

• 2
  Informed consent: Informed consent of the patients was obtained for publication of the cases.

Publication Dates

• Publication in this collection
  Mar-Apr 2018

History

• Received
  20 Apr 2017
• Accepted
  19 June 2017