Correspondence on the evaluation of patients with COVID-19 vaccine side effects

Dear Editor,

We would like to share ideas on the publication entitled “Evaluation of patients of vaccine side effects after the COVID-19 vaccine”¹. Gedik et al. sought to create a scientific database to catalog possible vaccination adverse effects¹. Although fatigue was the most frequent complaint in 29.7% of cases admitted to the emergency room following immunization, Gedik et al. discovered that the most frequent diagnoses following an emergency room assessment were myalgia in 32.1% of cases and upper respiratory tract infection in 28.6% of cases¹.

Comorbidities are rarely mentioned in clinical records, even when they do exist. It can occasionally be challenging to identify the specific patho-immuno-pharmacological relationship due to ignorance. It could also be challenging to comprehend how persistent medical conditions impact clinical results. Concern should also be expressed about the preceding asymptomatic COVID-19, which is not unusual². It is possible for the response to the vaccination and the result in a prior COVID-19 case to differ. Without proper laboratory testing, the effects of prior asymptomatic COVID-19 are often impossible to rule out. Genetics also plays a crucial role³. As the study's findings are not supported by any prior research, obtaining new evidence is challenging. There may be a need for additional study that takes other issues into account. A further prospective study and an accurate assessment of the patient's comorbidity are needed in order to draw a firm conclusion.

• Funding: none.

REFERENCES

• ¹
  Gedik MS, Kilci Aİ, Hakkoymaz H, Küçük ÖF, Solak Y, Basan NM, et al. Evaluation of patients of vaccine side effects after the COVID-19 vaccine. Rev Assoc Med Bras (1992). 2023;69(1):147-52. https://doi.org/10.1590/1806-9282.20221035
  » https://doi.org/10.1590/1806-9282.20221035
• ²
  Joob B, Wiwanitkit V. Letter to the editor: coronavirus disease 2019 (COVID-19), infectivity, and the incubation period. J Prev Med Public Health. 2020;53(2):70. https://doi.org/10.3961/jpmph.20.065
  » https://doi.org/10.3961/jpmph.20.065
• ³
  Čiučiulkaitė I, Möhlendick B, Thümmler L, Fisenkci N, Elsner C, Dittmer U, et al. GNB3 c. 825c> T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine. Front Genet. 2022;13:932043. https://doi.org/10.3389/fgene.2022.932043
  » https://doi.org/10.3389/fgene.2022.932043

Publication Dates

• Publication in this collection
  29 May 2023
• Date of issue
  2023

History

• Received
  26 Feb 2023
• Accepted
  16 Mar 2023