Abstract

VALENCA, ALEXANDRE MARTINS et al. Double-blind clonazepam vs placebo in panic disorder treatment. Arq. Neuro-Psiquiatr. [online]. 2000, vol.58, n.4, pp. 1025-1029. ISSN 0004-282X.  doi: 10.1590/S0004-282X2000000600008.

OBJECTIVE: To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients. METHOD: 24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV . All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included: change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale. RESULTS: At the therapeutic endpoint, only one of 9 placebo patients (11.1%) were free of panic attacks, compared with 8 of 13 (61.5%) clonazepam patients (Fisher exact test; p=0,031). CONCLUSION: the results provide evidence for the efficacy of clonazepam in panic disorder patients.

Keywords : panic disorder; panic attack; clonazepam; treatment.