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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053On-line version ISSN 1678-4790

Abstract

SANTINI, Alberto O. et al. Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk. J. Braz. Chem. Soc. [online]. 2009, vol.20, n.1, pp.64-73. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532009000100012.

The construction, evaluation and analytical application of a potentiometric sensor, namely, Pt|Hg|Hg2(Fur)2|Graphite, where Fur stands for 4-chloro-N-furfuryl-5-sulphamoyl-anthranilate ion, are described. This electrode has a linear dynamic range between 5.0 × 10-7-1.0 × 10-2 mol L-1 with a near-Nernstian slope of (-58.4± 0.9) mV decade-1 and a detection limit of 3.8 × 10-7 mol L-1. The potentiometric response is independent of the pH of the solution in the pH range 7.0-9.0. The electrode shows easy construction, low-cost, fast response time (within 10-20 s) and can be used for a period of 6 months without significant change in its performance characteristics. The proposed sensor displayed good selectivities over a variety of other anions (carboxylates and inorganic anions). Application of this potentiometric sensor for the furosemide determination in pharmaceuticals, urine, blood serum and commercial milk samples is reported.

Keywords : 4-cloro-N-furfuryl-5-sulphamoylanthranilate-sensitive electrode; potentiometry; pharmaceuticals; urine; human blood serum; bovine milk.

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