Abstract

SILVA, Maria do Rosário Rodrigues et al. Drug resistance of yeasts isolated from oropharyngeal candidiasis in aids patients. Rev. Microbiol. [online]. 1998, vol.29, n.4, pp. 271-275. ISSN 0001-3714.  http://dx.doi.org/10.1590/S0001-37141998000400007.

Candida spp was isolated from 59 (68.60%) out of eighty six samples of oral mucosa of AIDS patients. The identification, based or the production of a germ tube and chlamydospores, and on the assimilation and fermentation of carbohydrates, revealed 52 strains (88.13%) of C. albicans, 4 (6.77%) of C. tropicalis and 3 (5.08%) of C. krusei. The susceptibility of these strains to amphotericin B, flucytosine, itraconazole, fluconazole and ketoconazole was determined using the agar dilution method. Comparing the minimum inhibitory concentration values found in the susceptibility test with the serum levels achieved by these drugs, only 8.47% and 5.08% of the yeasts strains proved to be resistant to amphotericin B and flucitosyne, respectively. A high frequency of strains resistant to azole derivatives (25.42%, to itraconazole, 45.76%, to ketoconazole and 66.10% to fluconazole) was observed.

Keywords : Oropharyngeal candidiasis; yeasts; in vitro resistance; antifungal drugs.