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Anais da Academia Brasileira de Ciências
On-line version ISSN 1678-2690
MOREIRA, DAVYSON L. et al. Effect of leaf essential oil from Piper solmsianum C.DC. in mice behaviour. An. Acad. Bras. Ciênc. [online]. 2001, vol.73, n.1, pp. 33-57. ISSN 1678-2690. http://dx.doi.org/10.1590/S0001-37652001000100004.
The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0% v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals.
Keywords : Piperaceae; Piper solmsianum; essential oil; sarisan; psychopharmacologic effect.