Anais da Academia Brasileira de Ciências
versión impresa ISSN 0001-3765
MOREIRA, Maria Elisabete C. y BARCINSKI, Marcello A.. Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems. An. Acad. Bras. Ciênc. [online]. 2004, vol.76, n.1, pp. 93-115. ISSN 0001-3765. http://dx.doi.org/10.1590/S0001-37652004000100009.
Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.
Palabras llave : cell death; apoptosis; apoptotic cell recognition; apoptotic mimicry; phagocyte; intracellular signaling.