Abstract

SOUZA, Marta M.C. et al. Anthelmintic acetogenin from Annona squamosa L. Seeds. An. Acad. Bras. Ciênc. [online]. 2008, vol.80, n.2, pp. 271-277. ISSN 0001-3765.  http://dx.doi.org/10.1590/S0001-37652008000200005.

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml^-1. The structure of 1 was determined as a C₃₇ trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.

Keywords : Haemonchus contortus; nematodes; Annonacea; phytotherapy.