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Anais da Academia Brasileira de Ciências

versão impressa ISSN 0001-3765versão On-line ISSN 1678-2690

Resumo

CAMARA, Celso A. et al. Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives. An. Acad. Bras. Ciênc. [online]. 2008, vol.80, n.2, pp.329-334. ISSN 0001-3765.  http://dx.doi.org/10.1590/S0001-37652008000200011.

The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.

Palavras-chave : Biomphalaria glabrata; Artemia salina; toxicity; quinones; schistosomiasis; molluscicidal activity; lawsone; 1,4-naphthoquinone.

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