Anais da Academia Brasileira de Ciências
Print version ISSN 0001-3765
On-line version ISSN 1678-2690
PEREIRA, Aline C. et al. Identification of the antimicrobial substances produced by Solanum palinacanthum (Solanaceae). An. Acad. Bras. Ciênc. [online]. 2008, vol.80, n.3, pp.427-432. ISSN 0001-3765. http://dx.doi.org/10.1590/S0001-37652008000300004.
To find out natural antimicrobial agents as alternative in therapeutics and to preserve food, the methanol extract of Solanum palinacanthum aerial parts was submitted to purification steps guided by antibacterial and antifungal assays. As a consequence, the flavonoid rutin and 3,5-dicaffeoylquinic acid were isolated by column chromatographyand high performance liquid chromatography, and identified by mass and nuclear magnetic resonance spectrometry. Minimal inhibitory concentrations (MIC) of the quinic acid derivative against Aeromonas hydrophila, Bacillus subtilis, Staphylococcus aureus and the fungus Aspergillus ochraceus were 250, 1000, 1000 and > 568µg/mL, respectively. Against the same microorganisms, MIC for rutin were 1000, > 1000, > 1000 and 35µg/mL, respectively. Rutinwas very promising for A. ochraceus control, since its MIC against such fungus was close to the one observed for benzalkonium chloride, which is used as a fungicide in Brazil.
Keywords : Solanum palinacanthum; 3,5-dicaffeoylquinic acid; rutin; antimicrobial activity.