SciELO - Scientific Electronic Library Online

 
vol.87 issue2  suppl.Disaggregases, molecular chaperones that resolubilize protein aggregatesThe re-emergency and persistence of vaccine preventable diseases author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

Abstract

COLOMBO, ANA CAROLINE  and  RODRIGUES, MARCIO L.. Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis. An. Acad. Bras. Ciênc. [online]. 2015, vol.87, n.2, suppl., pp.1293-1309.  Epub Aug 04, 2015. ISSN 0001-3765.  https://doi.org/10.1590/0001-3765201520140704.

Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.

Keywords : Fungal Infections; Cryptococcus; meningitis; meningoencephalitis.

        · abstract in Portuguese     · text in English     · English ( pdf )