Reference |
Title |
Study Design |
Bastos et al. 2007BASTOS EM, NETO MS, ALVES MTS, GARCIA EB, SANTOS RA, HEINK T, PEREIRA JB and FERREIRA JM. 2007b. Histologic Analysis of Zafirlukast's Effect on Capsule Formation Around Silicone Implants. Aesth Plast Surg 31: 559-565.
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"Histologic analysis of zafirlukast's effect on capsule formation around silicone implants".
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Animals: 32 adult female Wistar rats. Groups: 3 groups that received both smooth and textured surface silicone mini-implant. Intervention: Intraperitoneal treatment with either vehicle or zafirlukast (1.25 or 5 mg/kg/day; for 90 days). Follow up: 90 days. Capsular evaluation: Histological (HE, trichrome and picrosirius red stain), and immunohistochemistry (anti-α-SMA antibody) analyses. |
Bastos et al. 2012BASTOS EM, SABINO NETO M, GARCIA EB, VEIGA DF, HAN YA, DENADAI R, SANTOS RDE A and FERREIRA LM. 2012. Effect of zafirlukast on capsular contracture around silicone implants in rats. Acta Cir Bras 27: 1-6.
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"Effect of zafirlukast on capsular contracture around silicone implants in rats".
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Animals: 40 adult female Wistar rats. Groups: 4 groups that received both smooth and textured surface silicone mini-implant. Intervention: Intraperitoneal treatment with either zafirlukast (1.25 mg/kg/day; during 90 days) or vehicle. Follow up: 90 days. Capsular evaluation: Intra-implant pressure measurement. |
Bergmann et al. 2014BERGMANN PA, TAMOURIDIS G, LOHMEYER JA, MAUSS KL, BECKER B, KNOBLOCH J, MAILANDER P and SIEMERS F. 2014. The effect of a bacterial contamination on the formation of capsular contracture with polyurethane breast implants in comparison with textured silicone implants: an animal study. JPRAS 67: 1364-1370.
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"The effect of a bacterial contamination on the formation of capsular contracture with polyurethane breast implants in comparison with textured silicone implants: an animal study".
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Animals: 80 adult female Wistar rats. Groups: 4 groups that received either textured surface or PU-coated silicone mini-implant. Intervention: Implant inoculation with vehicle or a standard volume of Staphylococcus epidermidis. Follow up: 60 days. Capsular evaluation: Histological (HE, trichrome, naphthol-ASD-acetatesterase and picrosirius red stain), immunohistochemistry (anti-CD3, anti-CD138, anti-Lysozyme, anti-Pax5 and anti-α-SMA antibodies), and microbiological analyses. |
Cardenas-Camarena et al. 2005 |
"Electrostimulation: uses and applications for periprosthetic capsular contracture: experimental model".
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Animals: 40 adult female Wistar rats; Groups: 10 groups that received both smooth and textured surface silicone min-implant. Intervention: Different protocols of local electrostimulation from the 3rd to the 15th postoperative day. Follow up: 16 days; Capsular evaluation: Histological (HE) analyses. |
Gancedo et al. 2008GANCEDO M, RUIZ-CORRO L, SALAZAR-MONTES A, RINCON AR and ARMENDARIZ-BORUNDA J. 2008. Pirfenidone prevents capsular contracture after mammary implantation. Aesth Plast Surg 32: 32-40.
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"Pirfenidone prevents capsular contracture after mammary implantation".
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Animals: 20 adult female Wistar rats. Groups: 2 groups that received both smooth and textured surface silicone mini-implant. Intervention: Intraperitoneal treatment with vehicle or Pirfenidone (PFD) (200 mg/Kg/day, for 60 days). Follow up: 60 days. Capsular evaluation: Histological (HE, trichrome, picrosirius red stain), immunohistochemistry (anti-TGF-β1, anti-α-SMA antibodies), and real-time PCR (TGF-β and collagen αI) analyses. |
Mendes et al. 2008MENDES PR, BINS-ELY J, LIMA EA, VASCONCELLOS ZA, D'ACAMPORA AJ and NEVES RD. 2008. Histological study on acute inflammatory reaction to polyurethane-coated silicone implants in rats. Acta Cir Bras 23: 93-101.
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"Histological study on acute inflammatory reaction to polyurethane-coated silicone implants in rats".
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Animals: 35 adult female Wistar rats. Groups: 7 groups that received PU-coated silicone mini-implant. Intervention: Contamination of implant cavity with 101, 103, or 105 bacteria/mL with implant immersions in anti-microbial solution or saline. Follow up: 30 days. Capsular evaluation: Histological (HE and picrosirius red stain) analyses. |
Vieira et al. 2010VIEIRA VJ, D'ACAMPORA AJ, MARCOS AB, DI GIUNTA G, DE VASCONCELLOS ZA, BINS-ELY J, D'ECA NEVES R and FIGUEIREDO CP. 2010. Vascular endothelial growth factor overexpression positively modulates the characteristics of periprosthetic tissue of polyurethane-coated silicone breast implant in rats. Plast Reconstr Surg 126: 1899-1910.
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"Vascular endothelial growth factor overexpression positively modulates the characteristics of periprosthetic tissue of polyurethane-coated silicone breast implant in rats".
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Animals: 34 adult female Wistar rats. Groups: 4 groups that received textured surface or PU-coated silicone mini-implant. Intervention: no intervention. Follow up: 30 and 60 days. Capsular evaluation: Histological (HE, trichrome, picrosirius red stain), immunohistochemistry (anti-VEGF, anti-TGF-β1, anti-α-SMA, and anti-MPX antibodies) analysis. |
Zimman et al. 2007ZIMMAN OA, TOBLLI J, STELLA I, FERDER M, FERDER L and INSERRA F. 2007. The effects of angiotensin-converting-enzyme inhibitors on the fibrous envelope around mammary implants. Plast Reconstr Surg 120: 2025-2033.
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"The effects of angiotensin-converting-enzyme inhibitors on the fibrous envelope around mammary implants".
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Animals: 24 adult female Wistar rats. Groups: 4 groups that received either smooth or textured surface silicone mini-implants. Intervention: angiotensin-converting enzyme inhibitor enalapril administered in drinking water, ad libitum. Follow up: 90 days. Capsular evaluation: Histological (HE, trichrome, picrosirius red stain), and immunohistochemistry (anti-TGF-β1 and anti-collagen type III antibodies) analysis. |