|
Gu et al. (2010GU F ET AL. 2010. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Cancer Epidemiol Biomarkers Prev 19: 2877-2887.) |
Case control |
Caucasian Women |
2080 breast cancer and 3453 controls |
No significant association was observed between 302 SNPs of the IGF-1 gene and breast cancer. |
|
Javadi et al. (2012JAVADI M, HEMATTI S and TAVASSOLI M. 2012. Polymorphic CA repeat length in insulin-like growth factor 1 and risk of breast cancer in Iranian women. Med Oncol 29: 516-520.) |
Case control |
Iranian Women |
215 breast cancer and 224 controls |
A strong association between the length of the allele polymorphism of the IGF-1 gene CA and the risk of breast cancer. |
|
Muendlein et al. (2013MUENDLEIN A ET AL. 2013. Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer. J Cancer Res Clin Oncol 139: 491-498.) |
Prospective cohort |
Austrian Women |
161 women HER2-positive breast cancer |
A significant association between the polymorphism of the IGF-1 gene (rs 2946834) and a worse prognosis of patients with HER2-positive breast cancer. |
|
Qian et al. (2011QIAN B, ZHENG H, YU H and CHEN K. 2011. Genotypes and phenotypes of IGF-1 and IGFBP-3 in breast tumors among Chinese women. Breast Cancer Res Treat 130: 217-226.) |
Case control |
Chinese Women |
403 breast cancer and 403 controls |
A significant association between the polymorphism of the IGF-1 gene (rs7965399) and breast cancer in a recessive model, with greater association in premenopausal women with negative estrogen receptor tumors. |
|
Canzian et al. (2010CANZIAN F ET AL. 2010. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-1 metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet 19: 3873-3884.) |
Case control |
Caucasian Women |
6292 breast cancer and 8135 controls |
No association between the SNPs of the IGF-1 gene and the risk of breast cancer. |
|
Henningson et al. (2011HENNINGSON M, HIETALA M, TÖRNGREN T, OLSSON H and JERNSTRÖM H. 2011. IGF-1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer. Fam Cancer 10: 173-185.) |
Cross-sectional |
Swedish Women |
325 women from breast cancer high-risk families |
No SNP and diplotypes were associated with IGF-1, however rare diplotypes were correlated with the early development of breast cancer. |
|
Sarkissyan et al. (2011SARKISSYAN M, MISHRA DK, WU Y, SHANG X, SARKISSYAN S and VADGAMA JV. 2011. IGF gene polymorphisms and breast cancer in African-American and Hispanic women. Int J Oncol38: 1663-1673.) |
Case control |
African-American and Hispanic Women |
268 breast cancer and 386 no breast cancer |
A significant association between the polymorphism of the IGF-1 gene and the risk of breast cancer, especially for the polymorphism of alleles non 19/non19. |
| Al-Ajmi et al. (2012) |
Case control |
Omani women |
147 cases and 134 control |
No association between the polymorphism of the IGF-1 gene CA (19) and breast cancer in women of Oman. |
|
Yaren et al. (2012YAREN A, TURGUT S, AYADA C, AKCILAR R, DEGIRMENCIOGLU S and GOKOZ DOGU G. 2012. Insulin-like growth factor 1 (IGF-1) gene polymorphism in patients with non-metastatic breast cancer. Gene 503: 244-247.) |
Cross-sectional |
Non-metastatic breast cancer patients, median age at disease onset was 49 years |
76 patients |
Polymorphism of the IGF-I gene can affect the prognosis of breast cancer, for patients with non-metastatic breast cancer patients with homozygous alleles non-19/non 19 had not a better prognosis. |
