SciELO - Scientific Electronic Library Online

 
vol.88 número4New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activityEvaluation of deciduous broadleaf forests mountain using satellite data using neural network method near Caspian Sea in North of Iran índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Anais da Academia Brasileira de Ciências

versão impressa ISSN 0001-3765versão On-line ISSN 1678-2690

Resumo

COSTA-SILVA, DANYLO R. et al. Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk. An. Acad. Bras. Ciênc. [online]. 2016, vol.88, n.4, pp.2349-2356.  Epub 01-Dez-2016. ISSN 0001-3765.  http://dx.doi.org/10.1590/0001-3765201620160169.

Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.

Palavras-chave : Breast cancer; risk factors; IGF-1; IGF-1 gene polymorphism.

        · texto em Inglês     · Inglês ( pdf epdf )