SciELO - Scientific Electronic Library Online

 
vol.89 issue2Occurrence of Dendrocephalus brasiliensis Pesta, 1921 (Crustacea, Anostraca) in the Caras river, southern Ceara, BrazilEcology of the non-native snail Sinotaia cf quadrata (Caenogastropoda: Viviparidae). A study in a lowland stream of South America with different water qualities author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

Abstract

MONTE, ZENAIDE S. et al. Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities. An. Acad. Bras. Ciênc. [online]. 2017, vol.89, n.2, pp.1051-1059. ISSN 0001-3765.  https://doi.org/10.1590/0001-3765201720160801.

A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.

Keywords : arylamidines; 2D spectroscopy; gram-negative bacteria; yeast; cytotoxicity.

        · text in English     · English ( pdf )