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Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

Abstract

VICTOR, MAURICIO M. et al. Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity. An. Acad. Bras. Ciênc. [online]. 2017, vol.89, n.3, pp.1369-1379.  Epub Aug 14, 2017. ISSN 0001-3765.  https://doi.org/10.1590/0001-3765201720160780.

Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.

Keywords : antitumor activity; chemical modification; derivative synthesis; natural products esters.

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