SciELO - Scientific Electronic Library Online

 
vol.90 issue1  suppl.2Recent Advances and Perspectives in Cancer Drug DesignNew Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

Abstract

PINHEIRO, LUIZ C.S.; FEITOSA, LÍVIA M.; SILVEIRA, FLÁVIA F. DA  and  BOECHAT, NUBIA. Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives. An. Acad. Bras. Ciênc. [online]. 2018, vol.90, n.1, suppl.2, pp.1251-1271. ISSN 0001-3765.  https://doi.org/10.1590/0001-3765201820170830.

According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.

Keywords : malaria; Plasmodium falciparum; artemisinin; hybrid.

        · text in English     · English ( pdf )