The antibacterial activity of plant extracts of the Lamiaceae family was evaluated against clinical isolates of multi-resistant Gram-negative bacteria by broth microdilution technique. Promising results were obtained considering that all extracts were active for at least two bacterial species with MIC ranging from 0.5 to 2.0 mg/mL.
Key words:
antibacterial; clinical isolates; Lamiaceae extracts; multidrug-resistant
| A. baumannii | K. pneumoniae | E. coli | P. aeruginosa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1* | A2* | A3* | K1* | K2* | K3* | E1* | E2* | E3* | P1* | P2* | P3* | |
| β-lactams | ||||||||||||
| Ampicilin | R | R | R | R | R | R | R | R | R | R | R | R |
| Cefepime | R | I | R | I | R | R | R | R | S | I | S | S |
| Cefotaxime | R | R | R | R | R | R | R | R | S | R | R | R |
| Ceftazidime | R | R | R | R | R | R | R | R | S | R | I | R |
| Cephalothin | R | R | R | R | R | R | R | R | S | R | R | R |
| Meropenem | R | S | R | S | S | R | S | S | S | S | R | S |
| Piperaciclin+Tazobactam | R | R | R | S | R | R | S | R | S | R | S | R |
| Aminoglycosides | ||||||||||||
| Amikacin | I | S | I | S | S | S | S | S | S | S | S | S |
| Gentamicin | R | R | S | R | R | R | S | R | R | S | S | S |
| Fluoroquinolones | ||||||||||||
| Ciprofloxacin | R | R | R | R | R | R | R | R | R | R | S | R |
| Plectranthus barbatus | Ocimun basilicum | Rosmarinus officinalis | Mentha sp. | ||
|---|---|---|---|---|---|
| MIC | MIC | MIC | MIC | ||
| A. baumannii | A1* | >2.0 | >2.0 | 1.0 | >2.0 |
| A2* | 2.0 | 2.0 | 2.0 | 2.0 | |
| A3* | >2.0 | >2.0 | >2.0 | >2.0 | |
| K. pneumoniae | K1* | 1.0 | >2.0 | >2.0 | >2.0 |
| K2* | 1.0 | >2.0 | 2.0 | >2.0 | |
| K3* | >2.0 | >2.0 | 0.5 | >2.0 | |
| E. coli | E1* | >2.0 | >2.0 | >2.0 | >2.0 |
| E2* | 1.0 | 2.0 | >2.0 | >2.0 | |
| E3* | >2.0 | >2.0 | >2.0 | >2.0 | |
| P. aeruginosa | P1* | >2.0 | >2.0 | >2.0 | 2.0 |
| P2* | 0.5 | >2.0 | >2.0 | 2.0 | |
| P3* | 1.0 | >2.0 | >2.0 | 2.0 |
