SciELO - Scientific Electronic Library Online

vol.90 número3Mutations in the melanocortin-1 receptor (MC1R) gene have no influence on the distinct patterns of melanic plumage found in the manakins of the genus Antilophia (Aves: Pipridae)Structural characterization of vegetative organs of the endangered Brazilian native species Hesperozygis ringens (Benth.) Epling índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Anais da Academia Brasileira de Ciências

versão impressa ISSN 0001-3765versão On-line ISSN 1678-2690


LUYEN, NGUYEN THI et al. Hypoglycemic property of triterpenoid saponin PFS isolated from Polyscias fruticosa leaves. An. Acad. Bras. Ciênc. [online]. 2018, vol.90, n.3, pp.2881-2886. ISSN 0001-3765.

This paper evaluated the inhibitory effect of 3-O-[β-d-glucopyranosyl-(1→4)-β-d-glucuronopyranosyl] oleanolic acid 28-O-β-d-glucopyranosyl ester (PFS), a major saponin isolated from Polyscias fruticosa leaves, on α-amylase and α-glucosidase, and its potential for reducing the postprandial blood glucose level in mice. In enzyme inhibition assays, PFS strongly inhibited porcine pancreas α-amylase and yeast α-glucosidase. Using the Lineweaver–Burk equation, we found that PFS inhibited porcine pancreas α-amylase in a mixed noncompetitive mode, and yeast α-glucosidase via noncompetitive inhibition. In the sucrose tolerance test, PFS at 100 mg/kg body weight significantly decreased the postprandial blood glucose level in mice fed a high-sucrose diet. These findings suggest that P. fruticosa leaves and their major saponin PFS can be used to prevent and treat diabetes and its complications.

Palavras-chave : Polyscias fruticosa; Araliaceae; α-amylase; α-glucosidase; hypoglycemia.

        · texto em Inglês     · Inglês ( pdf )