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Anais da Academia Brasileira de Ciências

versão impressa ISSN 0001-3765versão On-line ISSN 1678-2690

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LUYEN, NGUYEN THI et al. Hypoglycemic property of triterpenoid saponin PFS isolated from Polyscias fruticosa leaves. An. Acad. Bras. Ciênc. [online]. 2018, vol.90, n.3, pp.2881-2886. ISSN 0001-3765.  http://dx.doi.org/10.1590/0001-3765201820170945.

This paper evaluated the inhibitory effect of 3-O-[β-d-glucopyranosyl-(1→4)-β-d-glucuronopyranosyl] oleanolic acid 28-O-β-d-glucopyranosyl ester (PFS), a major saponin isolated from Polyscias fruticosa leaves, on α-amylase and α-glucosidase, and its potential for reducing the postprandial blood glucose level in mice. In enzyme inhibition assays, PFS strongly inhibited porcine pancreas α-amylase and yeast α-glucosidase. Using the Lineweaver–Burk equation, we found that PFS inhibited porcine pancreas α-amylase in a mixed noncompetitive mode, and yeast α-glucosidase via noncompetitive inhibition. In the sucrose tolerance test, PFS at 100 mg/kg body weight significantly decreased the postprandial blood glucose level in mice fed a high-sucrose diet. These findings suggest that P. fruticosa leaves and their major saponin PFS can be used to prevent and treat diabetes and its complications.

Palavras-chave : Polyscias fruticosa; Araliaceae; α-amylase; α-glucosidase; hypoglycemia.

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