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SOUZA, RODRIGO OCTÁVIO M.A. DE  and  MIRANDA, LEANDRO S. DE MARIZ E. Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles. An. Acad. Bras. Ciênc. [online]. 2019, vol.91, suppl.1, e20180751.  Epub Feb 14, 2019. ISSN 0001-3765.

The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. These efforts are the subject of the presented review.

Keywords : 1,2,3-Triazoles; Heterocycles; Regiosselectivity; arylation.

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