Arquivos Brasileiros de Endocrinologia & Metabologia
versión impresa ISSN 0004-2730
BONACCORSI, Antônio Carlos; LEITE, Denise Boechat y FARIA JUNIOR, Raul. Análise crítica da utilidade do teste de clonidina - hormônio de crescimento (GH) no diagnóstico do homem infértil. Arq Bras Endocrinol Metab [online]. 1999, vol.43, n.5, pp. 373-376. ISSN 0004-2730. http://dx.doi.org/10.1590/S0004-27301999000500010.
The aim of this study was to analyse the reliability of the GH - clonidine test (GH-CT) in the diagnosis of a relative GH insufficiency in an infertile male population. Twenty seven pacients were classified in 3 groups according to clonidine dosage. Groups I (clonidine 0.150mg) and II (clonidine 0.200mg) had 9 and 6 oligozoospermic patients, respectively. Group III (clonidine 0.400mg) had 5 oligozoospermic (subgroup IIIa) and 7 normozoospermic patients (subgroup IIIb). Thirty one GH-CT were performed and 29 of them were included in the study. Five (17.2%) normal GH-CT were observed (1 in group I, 1 in group II and 3 in subgroup IIIb). GH responses at 60, 90 and 120 min after clonidine stimulation showed no significant differences in groups I, II and III, neither between subgroups IIIa and IIIb. We conclude that the GH-CT is of no use in the diagnosis of a relative GH insufficiency in the infertile male, irrespective of the clonidine dosage. The reason is the clonidine inability to carry out a reliable GH stimulation in the adult male.
Palabras llave : Growth hormone; GH - clonidine test; Male infertility; GH insufficiency.