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vol.45 número6Análise das alterações cardiovasculares em adultos com deficiência de hormônio de crescimento através da dopplerecocardiografia e do teste de esforço cardiopulmonarCytogenetic analysis and detection of KAL-1 gene deletion with fluorescence in situ hybridization (FISH) in patients with Kallmann syndrome índice de autoresíndice de assuntospesquisa de artigos
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Arquivos Brasileiros de Endocrinologia & Metabologia

versão On-line ISSN 1677-9487

Resumo

CARVALHO, Luciani R.S. et al. Telarca reversível espontaneamente em meninas pré-púberes durante o tratamento com hormônio de crescimento recombinante humano. Arq Bras Endocrinol Metab [online]. 2001, vol.45, n.6, pp.547-551. ISSN 1677-9487.  http://dx.doi.org/10.1590/S0004-27302001000600007.

OBJECTIVE: Description of 4 cases of breast development in prepubertal girls treated with recombinant human growth hormone (rhGH). PATIENTS AND METHODS: Four prepubertal girls with short stature: 2 with Turner's syndrome (TS) and 2 with growth hormone deficiency (GHD). Breast development (Tanner II and III) was detected from ages 5.6 to 7.7 years and bone ages from 5.7 to 6.9 years, from 2 to 60 months after starting rhGH treatment doses of 0.1- 0.15U/kg/d. Breast development had disappeared 8 to 15 months after have been noted in all patients. Three patients were submitted to GnRH test that showed a prepubertal LH response. DISCUSSION: Prepubertal breast development has been reported in boys after rhGH treatment, but not in prepubertal girls. CONCLUSION: rhGH can induce transient breast development, even in girls, without activation of the hypothalamic-pituitary-gonadal axis and these patients do not need suppression of puberty.

Palavras-chave : Breast development; Thelarche; Growth hormone therapy.

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