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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


MEISTER, Ludimyla H. F.; BOGUSZEWSKI, Cesar L.; IOSHII, Sérgio O.  and  GRAF, Hans. A Malignant Insulinoma Producing Hypoglycemia. Arq Bras Endocrinol Metab [online]. 2002, vol.46, n.5, pp. 601-605. ISSN 1677-9487.

We report on a case of a 53-year-old woman with episodes of spontaneous hypoglycemia in the last year, before her first visit in our outpatient clinic. She complained of weakness, sweating and trembling specially after meals. Blood tests confirmed low plasma glucose values and elevated insulin and C-peptide levels. An abdominal computed tomography (CT) scan showed a large mass with calcifications in the pancreas tail. Surgery was performed and histological evaluation revealed a malignant insulinoma. Since then, she has been followed for twelve months with no symptoms of hypoglycemia and no evidence of relapse.

Keywords : Malignant insulinoma; Hypoglycemia; Beta cell carcinoma; Hyperinsulinism.

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